Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Jun-ichi Osuga"'
Autor:
Daisuke Yamamuro, Hisataka Yamazaki, Jun-ichi Osuga, Kenta Okada, Tetsuji Wakabayashi, Akihito Takei, Shoko Takei, Manabu Takahashi, Shuichi Nagashima, Adriaan G. Holleboom, Masayuki Kuroda, Hideaki Bujo, Shun Ishibashi
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 9, Pp 1287-1299 (2020)
The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of sterols in
Externí odkaz:
https://doaj.org/article/7b302d366e724dc48d0fc049e847b5aa
Autor:
Shuichi Nagashima, Hiroaki Yagyu, Ryuichi Tozawa, Fumiko Tazoe, Manabu Takahashi, Tetsuya Kitamine, Daisuke Yamamuro, Kent Sakai, Motohiro Sekiya, Hiroaki Okazaki, Jun-ichi Osuga, Akira Honda, Shun Ishibashi
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 5, Pp 998-1005 (2015)
Squalene synthase (SS) catalyzes the biosynthesis of squalene, the first specific intermediate in the cholesterol biosynthetic pathway. To test the feasibility of lowering plasma cholesterol by inhibiting hepatic SS, we generated mice in which SS is
Externí odkaz:
https://doaj.org/article/7b48d2ba7b554bd8aaf864108108d737
Autor:
Kent Sakai, Masaki Igarashi, Daisuke Yamamuro, Taichi Ohshiro, Shuichi Nagashima, Manabu Takahashi, Bolormaa Enkhtuvshin, Motohiro Sekiya, Hiroaki Okazaki, Jun-ichi Osuga, Shun Ishibashi
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 2033-2040 (2014)
Hydrolysis of intracellular cholesteryl ester (CE) is the rate-limiting step in the efflux of cholesterol from macrophage foam cells. In mouse peritoneal macrophages (MPMs), this process is thought to involve several enzymes: hormone-sensitive lipase
Externí odkaz:
https://doaj.org/article/53ac1491a9844d5ca276afa472350ef2
Autor:
Motohiro Sekiya, Daisuke Yamamuro, Taichi Ohshiro, Akira Honda, Manabu Takahashi, Masayoshi Kumagai, Kent Sakai, Shuichi Nagashima, Hiroshi Tomoda, Masaki Igarashi, Hiroaki Okazaki, Hiroaki Yagyu, Jun-ichi Osuga, Shun Ishibashi
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 2082-2092 (2014)
An excess of cholesterol and/or oxysterols induces apoptosis in macrophages, contributing to the development of advanced atherosclerotic lesions. In foam cells, these sterols are stored in esterified forms, which are hydrolyzed by two enzymes: neutra
Externí odkaz:
https://doaj.org/article/8b2678c6d9294aa8b1e9b627bef59173
Autor:
Manabu Takahashi, Hiroaki Yagyu, Fumiko Tazoe, Shuichi Nagashima, Taichi Ohshiro, Kenta Okada, Jun-ichi Osuga, Ira J. Goldberg, Shun Ishibashi
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 4, Pp 1124-1134 (2013)
The role of macrophage lipoprotein lipase (LpL) in the development of atherosclerosis and adiposity was examined in macrophage LpL knockout (MLpLKO) mice. MLpLKO mice were generated using cre-loxP gene targeting. Loss of LpL in macrophages did not al
Externí odkaz:
https://doaj.org/article/c9c7e93472544de980ca2577a50f5a74
Autor:
Masaki Igarashi, Jun-ichi Osuga, Masashi Isshiki, Motohiro Sekiya, Hiroaki Okazaki, Satoru Takase, Mikio Takanashi, Keisuke Ohta, Masayoshi Kumagai, Makiko Nishi, Toshiro Fujita, Ryozo Nagai, Takashi Kadowaki, Shun Ishibashi
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 2, Pp 274-285 (2010)
Neutral cholesterol ester hydrolase (NCEH) accounts for a large part of the nCEH activity in macrophage foam cells, a hallmark of atherosclerosis, but its subcellular localization and structure-function relationship are unknown. Here, we determined s
Externí odkaz:
https://doaj.org/article/f815b614640c4e6492d14abaaec03114
Autor:
Motohiro Sekiya, Jun-ichi Osuga, Naoya Yahagi, Hiroaki Okazaki, Yoshiaki Tamura, Masaki Igarashi, Satoru Takase, Kenji Harada, Sachiko Okazaki, Yoko Iizuka, Ken Ohashi, Hiroaki Yagyu, Mitsuyo Okazaki, Takanari Gotoda, Ryozo Nagai, Takashi Kadowaki, Hitoshi Shimano, Nobuhiro Yamada, Shun Ishibashi
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 8, Pp 1829-1838 (2008)
Hormone-sensitive lipase (HSL) regulates the hydrolysis of acylglycerol and cholesteryl ester (CE) in various organs, including adipose tissues. However, the hepatic expression level of HSL has been reported to be almost negligible. In the present st
Externí odkaz:
https://doaj.org/article/0ed931d6c3f4452982b8f76bf69f09ef
Autor:
Motohiro Sekiya, Naoya Yahagi, Takashi Matsuzaka, Yoshinori Takeuchi, Yoshimi Nakagawa, Haruka Takahashi, Hiroaki Okazaki, Yoko Iizuka, Ken Ohashi, Takanari Gotoda, Shun Ishibashi, Ryozo Nagai, Tsutomu Yamazaki, Takashi Kadowaki, Nobuhiro Yamada, Jun-ichi Osuga, Hitoshi Shimano
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 7, Pp 1581-1591 (2007)
Sterol regulatory element-binding protein (SREBP)-1c is now well established as a key transcription factor for the regulation of lipogenic enzyme genes such as FAS in hepatocytes. Meanwhile, the mechanisms of lipogenic gene regulation in adipocytes r
Externí odkaz:
https://doaj.org/article/bc0c89f25eb84e318295fcdfd4743774
Autor:
Hiroaki Okazaki, Fumiko Tazoe, Sachiko Okazaki, Naoyuki Isoo, Kazuhisa Tsukamoto, Motohiro Sekiya, Naoya Yahagi, Yoko Iizuka, Ken Ohashi, Tetsuya Kitamine, Ryu-ichi Tozawa, Toshihiro Inaba, Hiroaki Yagyu, Mitsuyo Okazaki, Hitoshi Shimano, Norihito Shibata, Hiroyuki Arai, Ryo-zo Nagai, Takashi Kadowaki, Jun-ichi Osuga, Shun Ishibashi
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 9, Pp 1950-1958 (2006)
Squalene synthase (SS) is the first committed enzyme for cholesterol biosynthesis, located at a branch point in the mevalonate pathway. To examine the role of SS in the overall cholesterol metabolism, we transiently overexpressed mouse SS in the live
Externí odkaz:
https://doaj.org/article/0cee168e2db842119125ed4abe60c0b3
Autor:
Michiyo Amemiya-Kudo, Hitoshi Shimano, Alyssa H. Hasty, Naoya Yahagi, Tomohiro Yoshikawa, Takashi Matsuzaka, Hiroaki Okazaki, Yoshiaki Tamura, Yoko Iizuka, Ken Ohashi, Jun-ichi Osuga, Kenji Harada, Takanari Gotoda, Ryuichiro Sato, Satoshi Kimura, Shun Ishibashi, Nobuhiro Yamada
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 8, Pp 1220-1235 (2002)
Recent studies on the in vivo roles of the sterol regulatory element binding protein (SREBP) family indicate that SREBP-2 is more specific to cholesterogenic gene expression whereas SREBP-1 targets lipogenic genes. To define the molecular mechanism i
Externí odkaz:
https://doaj.org/article/f098db7126f1440fb574af56b95da59f