Zobrazeno 1 - 10 of 111 pro vyhledávání: '"Jun-ichi Nishikawa"'
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A New Bitterness Evaluation Index Obtained Using the Taste Sensor for 48 Active Pharmaceutical Ingredients of Pediatric Medicines
Autor: Taku Yamashita, Takahiro Uchida, Masaaki Habara, Toshio Kurihara, Mitsuhiro Arisawa, Hidekazu Ikezaki, Miyako Yoshida, Hirofumi Tsujino, Saeri Ikegami, Haruka Nishikawa, Jun-ichi Nishikawa, Honami Kojima, Takayoshi Okuno, Tamami Haraguchi
Publikováno v: Chemicalpharmaceutical bulletin. 69(6)
The aim of this study was to evaluate bitterness by using "CCDP; Change in concentration-dependent potential" considering dose-dependency of active pharmaceutical ingredients (APIs) as new and useful bitterness evaluation index compared with bitter s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba65a87b9a532fca4f98614cbe7c87b
https://pubmed.ncbi.nlm.nih.gov/34078800
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3
Antimicrobial Activities of LL-37 Fragment Mutant-Poly (Lactic-Co-Glycolic) Acid Conjugate against Staphylococcus aureus, Escherichia coli, and Candida albicans
Autor: Rie Kakehashi, Takeshi Mori, Daisuke Ishibashi, Honami Kojima, Takahiro Uchida, Toshihiro Nagao, Ikuo Kawasaki, Taku Yamashita, Minoru Ozeki, Miyako Yoshida, Rio Uno, Mai Hazekawa, Jun-ichi Nishikawa, Yoshiro Hatanaka
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 10
International Journal of Molecular Sciences, Vol 22, Iss 5097, p 5097 (2021)
Various peptides and their derivatives have been reported to exhibit antimicrobial activities. Although these activities have been examined against microorganisms, novel methods have recently emerged for conjugation of the biomaterials to improve the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a068183aed98d6f78e715429499c0436
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4
Cytotoxic Effects of Water-Soluble Extracts of Coarse and Fine Atmospheric Particulate Matter on Mast Cell Lines
Autor: Hiromi Kataoka, Keiko Tazuya-Murayama, Jun-ichi Nishikawa, Kaori Tanaka, Taku Yamashita
Publikováno v: Biologicalpharmaceutical bulletin. 44(1)
Fine particulate matter (PM2.5) pollution causes serious health disorders, because PM2.5 becomes deposited in the tracheobronchial and alveoli regions. In the extrathoracic region, there are more deposits of coarse particulate matter than fine partic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c2ad669116fca7f8292b92b90dbb4a
https://pubmed.ncbi.nlm.nih.gov/33390550
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5
Bitterness-Suppressing Effect of Umami Dipeptides and Their Constituent Amino Acids on Diphenhydramine: Evaluation by Gustatory Sensation and Taste Sensor Testing
Autor: Tamami Haraguchi, Hirofumi Tsujino, Jun-ichi Nishikawa, Honami Kojima, Takahiro Uchida, Miyako Yoshida, Mitsuhiro Arisawa, Haruka Nishikawa, Shiori Morimoto, Taku Yamashita, Takayoshi Okuno, Masaaki Habara, Hidekazu Ikezaki
Publikováno v: Chemicalpharmaceutical bulletin. 68(3)
Diphenhydramine, a sedating antihistamine, is an agonist of human bitter taste receptor 14 (hTAS2R14). Diphenhydramine hydrochloride (DPH) was used as a model bitter medicine to evaluate whether the umami dipeptides (Glu-Glu and Asp-Asp) and their co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a6dfe8945e20fc0736432e01a5fb17
https://pubmed.ncbi.nlm.nih.gov/32115530
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6
Role of 6-O-α-maltosyl-β-cyclodextrin in lysosomal cholesterol deprivation in Npc1-deficient Chinese hamster ovary cells
Autor: Katsumi Higaki, Jun-ichi Nishikawa, Yasuyo Okada, Kousaku Ohno, Yoichi Ishitsuka, Erika Ueda, Keiichi Motoyama, Hidetoshi Arima, Yuki Kondo, Tetsumi Irie, Atsushi Ichikawa, Muneaki Matuso, Taishi Higashi
Publikováno v: Carbohydrate Research. 455:54-61
We aimed to investigate whether 6-O-α-maltosyl-β-cyclodextrin (Mal-βCD) is incorporated into cells and lysosomes during the release of unesterified cholesterol in Npc1-deficient Chinese hamster ovary (CHO) cells (Npc1 KO cells) and CHO-JP17 cells
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f3d41e4851846c3dc316f46f5d62dd
https://doi.org/10.1016/j.carres.2017.11.003
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8
In Vitro and In Vivo Evaluation of 6-O-α-Maltosyl-β-Cyclodextrin as a Potential Therapeutic Agent Against Niemann-Pick Disease Type C
Autor: Yasuyo Okada, Muneaki Matsuo, Jun-ichi Nishikawa, Daisuke Iohara, Naomi Nakagata, Taishi Higashi, Fumitoshi Hirayama, Toru Takeo, Keiichi Motoyama, Madoka Fukaura, Yoichi Ishitsuka, Tetsumi Irie, Katsumi Higaki, Yusei Yamada, Nushrat Yasmin, Yuki Kondo, Akira Ishii, Shuichi Nakahara, Kousaku Ohno, Atsushi Ichikawa
Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 5, p 1152 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 5
Niemann-Pick disease Type C (NPC) is a rare lysosomal storage disease characterized by the dysfunction of intracellular cholesterol trafficking with progressive neurodegeneration and hepatomegaly. We evaluated the potential of 6-O-α-maltosyl-β-cycl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff9de168c418eb4ffb5e996f2169f68
http://www.mdpi.com/1422-0067/20/5/1152
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9
Organotin compounds cause structure-dependent induction of progesterone in human choriocarcinoma Jar cells
Autor: Jun-ichi Nishikawa, Hisamitsu Nagase, Hiroki Yui, Youhei Hiromori, Tsuyoshi Nakanishi
Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 155:190-198
Organotin compounds, such as tributyltin (TBT) and triphenyltin (TPT), are typical environmental contaminants and suspected endocrine-disrupting chemicals because they cause masculinization in female mollusks. In addition, previous studies have sugge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8fd2c79a24d1daaafa0e7ddd425b3d
https://doi.org/10.1016/j.jsbmb.2014.10.010
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10
Identification of Candidate Target Cyp Genes for microRNAs Whose Expression Is Altered by PCN and TCPOBOP, Representative Ligands of PXR and CAR
Autor: Fumihiko Kugawa, Jun-ichi Nishikawa, Hiromi Kataoka, Nozomu Moriya
Publikováno v: Biological & Pharmaceutical Bulletin. 39:1381-1386
MicroRNAs (miRNAs) are small non-coding RNAs that are involved in mRNA post-transcriptional regulation. The deregulation of miRNAs affects the expression of drug-metabolizing enzymes, drug transporters, and nuclear receptors, all of which are importa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fbe42a804810a006c83a5bffb584036
https://doi.org/10.1248/bpb.b16-00279
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