Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Jun-ichi Kishikawa"'
Autor:
Dohyun Im, Mika Jormakka, Narinobu Juge, Jun-ichi Kishikawa, Takayuki Kato, Yukihiko Sugita, Takeshi Noda, Tomoko Uemura, Yuki Shiimura, Takaaki Miyaji, Hidetsugu Asada, So Iwata
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Human vesicular monoamine transporter 2 (VMAT2), a member of the SLC18 family, plays a crucial role in regulating neurotransmitters in the brain by facilitating their uptake and storage within vesicles, preparing them for exocytotic release.
Externí odkaz:
https://doaj.org/article/c1f588dce25945ba8399b5c51bbbd82f
Autor:
Dohyun Im, Jun-ichi Kishikawa, Yuki Shiimura, Hiromi Hisano, Akane Ito, Yoko Fujita-Fujiharu, Yukihiko Sugita, Takeshi Noda, Takayuki Kato, Hidetsugu Asada, So Iwata
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Histamine is a biogenic amine that participates in allergic and inflammatory processes by stimulating histamine receptors. The histamine H4 receptor (H4R) is a potential therapeutic target for chronic inflammatory diseases such as asthma and
Externí odkaz:
https://doaj.org/article/aecb7ce92dad48079fb1d6b2c25e5659
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract F1 domain of ATP synthase is a rotary ATPase complex in which rotation of central γ-subunit proceeds in 120° steps against a surrounding α3β3 fueled by ATP hydrolysis. How the ATP hydrolysis reactions occurring in three catalytic αβ di
Externí odkaz:
https://doaj.org/article/bcb92185cc3d4adb8176a1a345df52b1
Autor:
Junso Fujita, Fumiaki Makino, Haruyasu Asahara, Maiko Moriguchi, Shota Kumano, Itsuki Anzai, Jun-ichi Kishikawa, Yoshiharu Matsuura, Takayuki Kato, Keiichi Namba, Tsuyoshi Inoue
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Functionalization of graphene is one of the most important fundamental technologies in a wide variety of fields including industry and biochemistry. We have successfully achieved a novel oxidative modification of graphene using photoactivate
Externí odkaz:
https://doaj.org/article/eaacd8fd1a16491b9ebd4322dcaea0e7
Autor:
Tina Lusiany, Tohru Terada, Jun-ichi Kishikawa, Mika Hirose, David Virya Chen, Fuminori Sugihara, Hendra Saputra Ismanto, Floris J. van Eerden, Songling Li, Takayuki Kato, Hisashi Arase, Matsuura Yoshiharu, Masato Okada, Daron M. Standley
Publikováno v:
Viruses, Vol 15, Iss 12, p 2421 (2023)
The entry of SARS-CoV-2 into host cells is mediated by the interaction between the spike receptor-binding domain (RBD) and host angiotensin-converting enzyme 2 (ACE2). Certain human antibodies, which target the spike N-terminal domain (NTD) at a dist
Externí odkaz:
https://doaj.org/article/a2bc4d0f90d141fcb503218b93aede7c
Autor:
Jun-ichi Kishikawa, Moe Ishikawa, Takahiro Masuya, Masatoshi Murai, Yuki Kitazumi, Nicole L. Butler, Takayuki Kato, Blanca Barquera, Hideto Miyoshi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The Na+-pumping NADH-ubiquinone oxidoreductase (Na+-NQR) is a unique respiratory enzyme found in many pathogenic bacteria. Here, the authors present high-resolution cryo-EM structures of Na+-NQR from V. cholerae with or without a bound inhibitor.
Externí odkaz:
https://doaj.org/article/9ddb4f055cc94baea25575c6856ebbc2
Autor:
Jun-ichi Kishikawa, Atsuko Nakanishi, Aya Furuta, Takayuki Kato, Keiichi Namba, Masatada Tamakoshi, Kaoru Mitsuoka, Ken Yokoyama
Publikováno v:
eLife, Vol 9 (2020)
V-ATPase is an energy converting enzyme, coupling ATP hydrolysis/synthesis in the hydrophilic V1 domain, with proton flow through the Vo membrane domain, via rotation of the central rotor complex relative to the surrounding stator apparatus. Upon dis
Externí odkaz:
https://doaj.org/article/9b8c79b57c2a4057b6a108a7260c05dc
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
H+-ATPases employ a rotary catalytic mechanism to couple ATP synthesis/hydrolysis with proton translocation through the membrane. Here, the authors use high-resolution cryoEM to characterize three rotational states of a bacterial H+-ATPase, providing
Externí odkaz:
https://doaj.org/article/cfecab94ebe5407db9477c180e68a42b
Publikováno v:
Biophysics and Physicobiology, Vol 16 (2019)
Proton-translocating rotary ATPases couple proton influx across the membrane domain and ATP hydrolysis/synthesis in the soluble domain through rotation of the central rotor axis against the surrounding peripheral stator apparatus. It is a significant
Externí odkaz:
https://doaj.org/article/bb4ed790045548efb9da5cf279e8b2cc
Autor:
Jun-Ichi Kishikawa, Yuki Inoue, Makoto Fujikawa, Kenji Nishimura, Atsuko Nakanishi, Tsutomu Tanabe, Hiromi Imamura, Ken Yokoyama
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190213 (2018)
General anesthetics are indispensable for effective clinical care. Although, the mechanism of action of general anesthetics remains controversial, lipid bilayers and proteins have been discussed as their targets. In this study, we focused on the rela
Externí odkaz:
https://doaj.org/article/a0999540e1444d5e9af0e16dc9893230