Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Jun-ichi Furukawa"'
Autor:
Yoshiaki Hosokawa, Masatake Matsuoka, Yuko Sakai, Ryuichi Fukuda, Keizumi Matsugasaki, Kentaro Homan, Jun-ichi Furukawa, Tomohiro Onodera, Norimasa Iwasaki
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Introduction Growth plate damage in long bones often results in progressive skeletal growth imbalance and deformity, leading to significant physical problems. Gangliosides, key glycosphingolipids in cartilage, are notably abundant in articul
Externí odkaz:
https://doaj.org/article/c24eecb29b124dcba22b8c4ee80559ba
Autor:
Kei-ichiro Inamori, Katsuya Nakamura, Fumi Shishido, Jia-Chen Hsu, Masakazu Nagafuku, Takahiro Nitta, Junji Ikeda, Hidekane Yoshimura, Minori Kodaira, Naomi Tsuchida, Naomichi Matsumoto, Satoshi Uemura, Shiho Ohno, Noriyoshi Manabe, Yoshiki Yamaguchi, Akira Togayachi, Kiyoko F. Aoki-Kinoshita, Shoko Nishihara, Jun-ichi Furukawa, Tadashi Kaname, Masahiko Nakamura, Takayoshi Shimohata, Shu Tadaka, Matsuyuki Shirota, Kengo Kinoshita, Yutaka Nakamura, Isao Ohno, Yoshiki Sekijima, Jin-ichi Inokuchi
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Hereditary spastic paraplegia (HSP) is a heterogeneous group of neurological disorders that are characterized by progressive spasticity and weakness in the lower limbs. SPG26 is a complicated form of HSP, which includes not only weakness in the lower
Externí odkaz:
https://doaj.org/article/71c917f9d2d54bdf92d9ba2611dfc30c
Autor:
Shungo Iwamoto, Takashi Kobayashi, Hisatoshi Hanamatsu, Ikuko Yokota, Yukiko Teranishi, Akiho Iwamoto, Miyu Kitagawa, Sawako Ashida, Ayane Sakurai, Suguru Matsuo, Yuma Myokan, Aiyu Sugimoto, Ryo Ushioda, Kazuhiro Nagata, Noriko Gotoh, Kazuki Nakajima, Takashi Nishikaze, Jun-ichi Furukawa, Naoki Itano
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Chronic metabolic stress paradoxically elicits pro-tumorigenic signals that facilitate cancer stem cell (CSC) development. Therefore, elucidating the metabolic sensing and signaling mechanisms governing cancer cell stemness can provide insig
Externí odkaz:
https://doaj.org/article/559c25e8eb7144b7a7e74df1a609d121
Autor:
Kentaro Homan, Tomohiro Onodera, Hisatoshi Hanamatsu, Jun-ichi Furukawa, Daisuke Momma, Masatake Matsuoka, Norimasa Iwasaki
Publikováno v:
eLife, Vol 12 (2024)
This study aimed to investigate the glycan structural changes that occur before histological degeneration in osteoarthritis (OA) and to determine the mechanism by which these glycan conformational changes affect cartilage degeneration. An OA model wa
Externí odkaz:
https://doaj.org/article/ad0a205eda70458e8bba0b5b1842d893
Autor:
Eriko Aoki, Noriyoshi Manabe, Shiho Ohno, Taiga Aoki, Jun-Ichi Furukawa, Akira Togayachi, Kiyoko Aoki-Kinoshita, Jin-Ichi Inokuchi, Kenji Kurosawa, Tadashi Kaname, Yoshiki Yamaguchi, Shoko Nishihara
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 37, Iss , Pp 101016- (2023)
Rare diseases are estimated to affect 3.5%–5.9% of the population worldwide and are difficult to diagnose. Genome analysis is useful for diagnosis. However, since some variants, especially missense variants, are also difficult to interpret, tools t
Externí odkaz:
https://doaj.org/article/9a483fec4a0e4c73898ecb681d86b97e
Autor:
Marietta Fabiano, Naoto Oikawa, Anja Kerksiek, Jun-ichi Furukawa, Hirokazu Yagi, Koichi Kato, Ulrich Schweizer, Wim Annaert, Jongkyun Kang, Jie Shen, Dieter Lütjohann, Jochen Walter
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5417 (2024)
Presenilin proteins (PS1 and PS2) represent the catalytic subunit of γ-secretase and play a critical role in the generation of the amyloid β (Aβ) peptide and the pathogenesis of Alzheimer disease (AD). However, PS proteins also exert multiple func
Externí odkaz:
https://doaj.org/article/af385f8c8b2f4b14a98185444d0c55c1
Autor:
Nagako Kawashima, Shokichi Naito, Hisatoshi Hanamatsu, Masaki Nagane, Yasuo Takeuchi, Jun-ichi Furukawa, Norimasa Iwasaki, Tadashi Yamashita, Ken-ichi Nakayama
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Podocytopathy, which is characterized by injury to podocytes, frequently causes proteinuria or nephrotic syndrome. There is currently a paucity of effective therapeutic drugs to treat proteinuric kidney disease. Recent research suggests the
Externí odkaz:
https://doaj.org/article/0216426e782d4e3f8a41540bff09bd55
Autor:
Federico Pecori, Ikuko Yokota, Hisatoshi Hanamatsu, Taichi Miura, Chika Ogura, Hayato Ota, Jun-ichi Furukawa, Shinya Oki, Kazuo Yamamoto, Osamu Yoshie, Shoko Nishihara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Embryonic stem cells (ESCs) and epiblast-like cells (EpiLCs) recapitulate in vitro the epiblast first cell lineage decision, allowing characterization of the molecular mechanisms underlying pluripotent state transition. Here, we performed a
Externí odkaz:
https://doaj.org/article/c2bda6e3df6349d5b749d60c512ff8ee
Autor:
Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Jun-ichi Furukawa, Noritaka Hashii, Akiko Ishii-Watabe, Ying Deng, Kazutoshi Matsushita, Tokiro Ishikawa, Yugoviandi P Mamahit, Yuta Maki, Yasuhiro Kajihara, Koichi Kato, Tetsuya Okada, Kazutoshi Mori
Publikováno v:
eLife, Vol 10 (2021)
Sequential mannose trimming of N-glycan, from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). We previo
Externí odkaz:
https://doaj.org/article/341ffd41c9234c5d998d7ae1195a462d
Autor:
Nobuaki Miura, Hisatoshi Hanamatsu, Ikuko Yokota, Keiko Akasaka-Manya, Hiroshi Manya, Tamao Endo, Yasuro Shinohara, Jun-ichi Furukawa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13097 (2022)
Glycans are involved in many fundamental cellular processes such as growth, differentiation, and morphogenesis. However, their broad structural diversity makes analysis difficult. Glycomics via mass spectrometry has focused on the composition of glyc
Externí odkaz:
https://doaj.org/article/a61892c1e8a34859b50af4e75057326c