Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jun-ichi Eguchi"'
Autor:
Daiki Sakai, Kazutoshi Watanabe, Mika Nabeno, Hiroshi Tanaka, Shinji Tanaka, Shinji Sunada, Jun-ichi Eguchi, Keiko Takiguchi-Hayashi, Ken-Ichi Saito, Shin-ichi Kusaka, Kazuki Nakayama, Kenji Fukunaga, Toshiyuki Kohara, Tomoko Bessho, Takashi Horikawa, Akiko Mori
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(16)
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 3-methylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in pot
Autor:
Adachi Takashi, Narihiko Yoshii, Kazutoshi Watanabe, Fumiaki Uehara, Mika Nabeno, Takashi Horikawa, Kenji Fukunaga, Ken-Ichi Saito, Shinji Sunada, Satoshi Yokoshima, Shinji Tanaka, Satoshi Yuki, Shouichi Asano, Aya Shouda, Hiroshi Tanaka, Shinsuke Hiki, Keiichi Aritomo, Masatake Fujimura, Keiji Yamagami, Yoshihiro Usui, Jun-ichi Eguchi
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(16)
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in pot
Autor:
Jun-ichi Eguchi, Shinsuke Hiki, Masatake Fujimura, Satoshi Yuki, Shinji Sunada, Tokushi Hanano, Masahiro Okuyama, Fumiaki Uehara, Toshiyuki Kohara, Hiroshi Tanaka, Keiichi Aritomo, Susumu Tsuchiya, Ken-Ichi Saito, Kenji Fukunaga, Kazutoshi Watanabe, Shoichi Asano, Koichi Yamakoshi, Hiroshi Baba, Shinji Tanaka, Takashi Horikawa, Yoshihiro Usui, Aya Shoda, Akiko Mori, Keiji Yamagami
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6933-6937
A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3β (GSK-3β). We found 21, 29 and 30 to possess potent in vitro GSK-3β inhibitory activity with g
Publikováno v:
Journal of Neural Transmission. 115:1037-1046
MKC-231, a putative cholinergic activity, is reported to improve learning and memory impaired in AF64A-treated animals. MKC-231 enhances high-affinity choline uptake (HACU) known as the rate-limiting step of acetylcholine (ACh) synthesis. We investig
Publikováno v:
Journal of Neural Transmission. 115:1027-1035
The effect of MKC-231 on acetylcholine (ACh) synthesis and release was studied in the hippocampus of normal and AF64A-treated rats. AF64A (3 nmol/brain, i.c.v.) produced significant reduction of high-affinity choline uptake (HACU) and high K+-induced
Autor:
Yoshio, Deguchi, Keitaro, Mitamura, Shunsuke, Omotaka, Jun-ichi, Eguchi, Dai, Sakuma, Masashi, Sato, Norihiro, Nomura, Takayoshi, Ito, Kevin Lawrence, Grimes, Haruhiro, Inoue
Publikováno v:
Asian journal of endoscopic surgery. 8(3)
Laparoscopic cholecystectomy has become the gold standard for the treatment of cholelithiasis, and many reports of single-incision laparoscopic cholecystectomy have been published in the past few years. Situs inversus totalis is a very rare condition
Autor:
Ryoichi Ando, Satoshi Yuki, Takuro Niwa, Takahide Kaji, Hiroaki Ueno, Hideo Kubodera, Ken-Ichi Saito, Jun-ichi Eguchi, Kenji Fukunaga, Shoichi Asano, Fumiaki Uehara, Keiichi Aritomo, Shinji Sunada, Aya Shoda, Masaki Shinoda, Shinji Tanaka, Yukimi Yoneyama, Kazutoshi Watanabe
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(24)
The discovery of a series of 6-(4-pyridyl)pyrimidin-4(3H)-ones derived from a hit compound with low molecular weight and sufficient chemical space is reported. Transformation of substituents led to subnanomolar potent inhibitors with in vivo tau phos
Publikováno v:
Journal of neural transmission (Vienna, Austria : 1996). 115(7)
MKC-231 is reported to increase high-affinity choline uptake (HACU) in vitro and improve learning impairment on a single oral administration in AF64A-treated rats. In this study, we investigated the effects of repeated administration of MKC-231 (1 an
Publikováno v:
Anticancer research. 23(3B)
Dendritic cells (DCs) play a critical role in the immune response. The aim of this study was to investigate apoptotic tumor cells as an antigen source for DC maturation.We compared the efficacy of ultraviolet (UV)-irradiation with that of gamma-irrad
Autor:
Ryuji Suga, Takayoshi Yoshida, Kouichi Tsukimoto, Naoko Tojo, Kouichi Makiguchi, Masahiko Ichioka, Jun-ichi Eguchi, Mamoru Chida
Publikováno v:
Control of Breathing and Its Modeling Perspective ISBN: 9781475798494
Since Zuntz and Geppert11 proposed that exercise-induced hyperpnea is caused by a blood-borne substance, there has been a debate about roles of neural and humoral mechanisms in this phenomenon. Occlusion of blood flow to the leg has been used to elim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44d9157c2258c789926234a977939864
https://doi.org/10.1007/978-1-4757-9847-0_49
https://doi.org/10.1007/978-1-4757-9847-0_49