Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Jun-dal Kim"'
Autor:
Asako Yanagisawa, Jun-Dal Kim, Akira Naito, Takayuki Kobayashi, Tomoko Misawa, Seiichiro Sakao, Takayuki Jujo-Sanada, Takeshi Kawasaki, Shin-ichi Muroi, So-Ichiro Sasaki, Takuji Suzuki, Yoshihiro Hayakawa, Yoshimi Nakagawa, Yoshitoshi Kasuya, Koichiro Tatsumi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Pulmonary hypertension (PH) is a devastating disease characterized by vascular remodeling, resulting in right ventricular failure and death. Dysregulation of energy metabolism is linked to PH pathogenesis. Trimetazidine (TMZ), a selective lo
Externí odkaz:
https://doaj.org/article/fb971edd85ca40dab0b58f9346fbd551
Autor:
Mosaburo Kainuma, Shinobu Kawakatsu, Jun-Dal Kim, Shinji Ouma, Osamu Iritani, Ken-Ichiro Yamashita, Tomoyuki Ohara, Shigeki Hirano, Shiro Suda, Tadanori Hamano, Sotaro Hieda, Masaaki Yasui, Aoi Yoshiiwa, Seiji Shiota, Masaya Hironishi, Kenji Wada-Isoe, Daiki Sasabayashi, Sho Yamasaki, Masayuki Murata, Kouta Funakoshi, Kouji Hayashi, Norimichi Shirafuji, Hirohito Sasaki, Yoshinori Kajimoto, Yukiko Mori, Michio Suzuki, Hidefumi Ito, Kenjiro Ono, Yoshio Tsuboi
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Alzheimer’s disease (AD), the most prevalent form of dementia, is a debilitating, progressive neurodegeneration. Amino acids play a wide variety of physiological and pathophysiological roles in the nervous system, and their levels and d
Externí odkaz:
https://doaj.org/article/22b6495c96ca47959b8406562eb0533d
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Activin, a member of the transforming growth factor-β (TGF-β) superfamily of proteins, induces various tissues from the amphibian presumptive ectoderm, called animal cap explants (ACs) in vitro. However, it remains unclear how and to what
Externí odkaz:
https://doaj.org/article/05b23392bb6a48028a2a2c2885373c27
Autor:
Tra Thi Huong Dinh, Hiroyoshi Iseki, Seiya Mizuno, Saori Iijima-Mizuno, Yoko Tanimoto, Yoko Daitoku, Kanako Kato, Yuko Hamada, Ammar Shaker Hamed Hasan, Hayate Suzuki, Kazuya Murata, Masafumi Muratani, Masatsugu Ema, Jun-Dal Kim, Junji Ishida, Akiyoshi Fukamizu, Mitsuyasu Kato, Satoru Takahashi, Ken-ichi Yagami, Valerie Wilson, Ruth M Arkell, Fumihiro Sugiyama
Publikováno v:
eLife, Vol 10 (2021)
In vivo function of CDK5 and Abl enzyme substrate 2 (Cables2), belonging to the Cables protein family, is unknown. Here, we found that targeted disruption of the entire Cables2 locus (Cables2d) caused growth retardation and enhanced apoptosis at the
Externí odkaz:
https://doaj.org/article/47b0afb571434225ae530bc466486e2e
Autor:
Kazuya Murata, Weizhe Lu, Misuzu Hashimoto, Natsumi Ono, Masafumi Muratani, Kana Nishikata, Jun-Dal Kim, Shizufumi Ebihara, Junji Ishida, Akiyoshi Fukamizu
Publikováno v:
iScience, Vol 8, Iss , Pp 200-213 (2018)
Summary: Protein arginine methyltransferase 1 (PRMT1) catalyzes the asymmetric dimethylation of arginine residues in proteins and methylation of various RNA-binding proteins and is associated with alternative splicing in vitro. Although PRMT1 has ess
Externí odkaz:
https://doaj.org/article/1db64ca2e9cb46f8b3e309a46321b119
Autor:
Masayoshi Ohkuro, Jun-Dal Kim, Yoshikazu Kuboi, Yuki Hayashi, Hayase Mizukami, Hiroko Kobayashi-Kuramochi, Kenzo Muramoto, Manabu Shirato, Fumiko Michikawa-Tanaka, Jun Moriya, Teruya Kozaki, Kazuma Takase, Kenichi Chiba, Kishan Lal Agarwala, Takayuki Kimura, Makoto Kotake, Tetsuya Kawahara, Naoki Yoneda, Shinsuke Hirota, Hiroshi Azuma, Nobuko Ozasa-Komura, Yoshiaki Ohashi, Masafumi Muratani, Keiji Kimura, Ieharu Hishinuma, Akiyoshi Fukamizu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Inflammatory bowel disease (IBD) is initiated by integrins-mediated leukocyte adhesion to the activated colonic microvascular endothelium. Here, the authors show that inhibition of the calreticulin binding to integrin α subunits ameliorates the seve
Externí odkaz:
https://doaj.org/article/ab36e151b5164ae2950d771f04fd0496
Autor:
Yasunari Yamada, Hodaka Saito, Masaya Araki, Yuhei Tsuchimoto, Shin-ichi Muroi, Kyohei Suzuki, Kazufumi Toume, Jun-Dal Kim, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano, Yoshimi Nakagawa
Publikováno v:
Nutrients; Volume 14; Issue 19; Pages: 3920
Fibroblast growth factor 21 (FGF21), which is mainly synthesized and secreted by the liver, plays a crucial role in systemic glucose and lipid metabolism, ameliorating metabolic diseases. In this study, we screened the WAKANYAKU library derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790cec323afe3c1e90682f50d24de89e
Autor:
Mitsuharu Endo, Junji Ishida, Sowmya Sekizar, Weizhe Lu, Tsutomu Nakagawa, Kazuya Murata, Ayako Kumabe, Akiyoshi Fukamizu, Anna Williams, Jun-Dal Kim, Misuzu Hashimoto, Yasuhiroasuhiro Minami
Publikováno v:
Journal of Neurochemistry. 156:834-847
PRMT1, a major arginine methyltransferase, plays critical roles in transcription, DNA damage response, and cell proliferation. Although we have previously discovered the crucial roles of PRMT1 for oligodendrocyte lineage progression in the central ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1979b78fd31f0d12a1d568f7178c7715
https://doi.org/10.1111/jnc.15149
https://doi.org/10.1111/jnc.15149
Autor:
Jun Ikari, Keita Ugai, Shuichi Matsuda, Akiyoshi Fukamizu, Hideki Mikami, Yoshitoshi Kasuya, Koichiro Tatsumi, Masahiko Hatano, Kenichi Suzuki, Jun-Dal Kim, Kento Yoshioka
Publikováno v:
Molecular Medicine Reports
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown etiology. Under pathological conditions in lungs with IPF, myofibroblasts serve a key role in fibrogenesis via the accumulation of an excessive amount of extracellular matrix. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e2b9e8b75872a2f926788adab2d9c5
https://tsukuba.repo.nii.ac.jp/records/2001714
https://tsukuba.repo.nii.ac.jp/records/2001714
Autor:
Tomohiro Ishimaru, Jun-Dal Kim, Hiroshi Ohtsu, Joichi Usui, Weizhe Lu, Junji Ishida, Hayase Mizukami, Koichiro Kako, Shohei Kawasaki, Naoto Muromachi, Kunihiro Yamagata, Kazuyuki Noguchi, Akiyoshi Fukamizu, Shuzo Kaneko
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Significance Histamine has been known to play important roles in inflammation, and its inhibition has been expected to ameliorate the pathological statement of heart failure and chronic kidney disease. In this paper, we found that histamine is elevat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58128c7cde4bbfc67cdca2892bf9f229
https://tsukuba.repo.nii.ac.jp/records/55905
https://tsukuba.repo.nii.ac.jp/records/55905