Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jun-Wan Shin"'
Autor:
Doo Eun Choi, Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M Loupe, Vanessa C Wheeler, Hannah E Stutzman, Ben Kleinstiver, Jong-Min Lee
Publikováno v:
eLife, Vol 12 (2024)
An expanded CAG repeat in the huntingtin gene (HTT) causes Huntington’s disease (HD). Since the length of uninterrupted CAG repeat, not polyglutamine, determines the age-at-onset in HD, base editing strategies to convert CAG to CAA are anticipated
Externí odkaz:
https://doaj.org/article/be3156c656d24edfa4a721019c3ab21e
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28065 (2011)
Exposure to ultraviolet-B (UVB) radiation induces inflammation and photocarcinogenesis in mammalian skin. Docosahexaenoic acid (DHA), a representative ω-3 polyunsaturated fatty acid, has been reported to possess anti-inflammatory and chemopreventive
Externí odkaz:
https://doaj.org/article/2e398a035b824c4cbfb9c0e65ad4437a
Allele-specific silencing of the gain-of-function mutation in Huntington’s disease using CRISPR/Cas9
Autor:
Jun Wan Shin, Eun Pyo Hong, Seri S. Park, Doo Eun Choi, Ihn Sik Seong, Madelynn N. Whittaker, Benjamin P. Kleinstiver, Richard Z. Chen, Jong-Min Lee
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Dominant gain-of-function mechanisms in Huntington’s disease (HD) suggest that selective silencing of mutant HTT produces robust therapeutic benefits. Here, capitalizing on exonic protospacer adjacent motif–altering (PAM-altering) SNP (PAS), we d
Externí odkaz:
https://doaj.org/article/8c4d07b7f240401da0278594ea55cf8a
Autor:
Doo Eun Choi, Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M. Loupe, Vanessa C. Wheeler, Hannah E. Stutzman, Benjamin P. Kleinstiver, Jong-Min Lee
Publikováno v:
bioRxiv
An expanded CAG repeat in the huntingtin gene (HTT) causes Huntington’s disease (HD). Since the length of uninterrupted CAG repeat, not polyglutamine, determines the age-at-onset in HD, base editing strategies to convert CAG to CAA are anticipated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95978ca0d623b50e7eb2b21c91a6b50
https://doi.org/10.1101/2023.04.28.538700
https://doi.org/10.1101/2023.04.28.538700
Autor:
Young-Joon Surh, Hajime Ohigashi, Hye-Kyung Na, Joydeb Kumar Kundu, Jeong-Sang Lee, Akira Murakami, Kohta Ohnishi, Jun-Wan Shin
Zerumbone, a sesquiterpene derived from tropical ginger, contains an electrophilic α,β-unsaturated carbonyl moiety and was found to suppress chemically induced papilloma formation in mouse skin. Here, we report that topical application of zerumbone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71f4b1467ab43b16c16d74a547224d8b
https://doi.org/10.1158/1940-6207.c.6544470
https://doi.org/10.1158/1940-6207.c.6544470
Autor:
Young-Joon Surh, Hajime Ohigashi, Hye-Kyung Na, Joydeb Kumar Kundu, Jeong-Sang Lee, Akira Murakami, Kohta Ohnishi, Jun-Wan Shin
Supplementary Figure S1 from Zerumbone Induces Heme Oxygenase-1 Expression in Mouse Skin and Cultured Murine Epidermal Cells through Activation of Nrf2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cdfb17b4a7bec640b99b000a2e9d25
https://doi.org/10.1158/1940-6207.22524882.v1
https://doi.org/10.1158/1940-6207.22524882.v1
Autor:
Michael J Chao, Kyung-Hee Kim, Jun Wan Shin, Diane Lucente, Vanessa C Wheeler, Hong Li, Jared C Roach, Leroy Hood, Nancy S Wexler, Laura B Jardim, Peter Holmans, Lesley Jones, Michael Orth, Seung Kwak, Marcy E MacDonald, James F Gusella, Jong-Min Lee
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007274 (2018)
Modifiers of Mendelian disorders can provide insights into disease mechanisms and guide therapeutic strategies. A recent genome-wide association (GWA) study discovered genetic modifiers of Huntington's disease (HD) onset in Europeans. Here, we perfor
Externí odkaz:
https://doaj.org/article/5931f4866f45429eade3b1d4c42f0e25
Autor:
Jun Wan Shin, Eun Pyo Hong, Seri S. Park, Doo Eun Choi, Sophia Zeng, Richard Z. Chen, Jong-Min Lee
Publikováno v:
Molecular therapy. Methodsclinical development. 26
Huntington's disease (HD) is caused by an expanded CAG repeat in huntingtin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199e4ca3b824176ec11bd009bc6fd8d9
https://pubmed.ncbi.nlm.nih.gov/36092363
https://pubmed.ncbi.nlm.nih.gov/36092363
Autor:
Liza D Morales, Edgar A Casillas Pavón, Jun Wan Shin, Alexander Garcia, Mario Capetillo, Dae Joon Kim, Jonathan H Lieman
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97104 (2014)
To maintain tissue homeostasis, apoptosis is functionally linked to the cell cycle through the retinoblastoma (Rb)/E2F pathway. When the Rb tumor suppressor protein is functionally inactivated, E2F1 elicits an apoptotic response through both intrinsi
Externí odkaz:
https://doaj.org/article/e5ee4627ffe04d4396634ed3c5ab3586
Autor:
Marcy E. MacDonald, Jeffrey D. Long, Jongmin Lee, Michael J. Chao, Peter Holmans, Tammy Gillis, Jayalakshmi S. Mysore, Jacob M. Loupe, Michael Orth, Lesley Jones, Darren G. Monckton, Kyung Hee Kim, Jun-Wan Shin, Eun Pyo Hong, Seung Kwak, James F. Gusella, Ramee Lee
Publikováno v:
Am J Hum Genet
A recent genome-wide association study of Huntington’s disease (HD) implicated genes involved in DNA \ud maintenance processes as modifiers of onset, including multiple genome-wide significant signals in a chr15 \ud region containing the DNA repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d80a57a1a1ec986be0b057852168a0
https://orca.cardiff.ac.uk/id/eprint/131840/1/FAN1.AJHG.accepted.version.pdf
https://orca.cardiff.ac.uk/id/eprint/131840/1/FAN1.AJHG.accepted.version.pdf