Identification of SRY‐box 30 as an age‐related essential gatekeeper for male germ‐cell meiosis and differentiation

Autor: Xiang-Lin Hao, Xiao Jiang, Jinyi Liu, Fei Gao, Ning Zhang, Li Yin, Yongsheng Huang, Jia Cao, Hongqiang Chen, Weiming Ouyang, Qiao-Nan Guo, Xi Zhang, Jun-Tang Yang, Fei Han, Wen-bin Liu, Zhong-Tai Li

Publikováno v: Aging Cell
Han, F, Yin, L, Jiang, X, Zhang, X, Zhang, N, Yang, J T, Ouyang, W M, Hao, X L, Liu, W B, Huang, Y S, Chen, H Q, Gao, F, Li, Z T, Guo, Q N, Cao, J & Liu, J Y 2021, ' Identification of SRY-box 30 as an age-related essential gatekeeper for male germ-cell meiosis and differentiation ', Aging Cell, vol. 20, no. 5, e13343 . https://doi.org/10.1111/acel.13343

Although important factors governing the meiosis have been reported in the embryonic ovary, meiosis in postnatal testis remains poorly understood. Herein, we first report that SRY‐box 30 (Sox30) is an age‐related and essential regulator of meiosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f68aeac16006b9b83bc0bd9f124dae
http://europepmc.org/articles/PMC8135013

Up‐regulated miR‐192‐5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2 ‐mediated TGF‐β1 signaling pathway

Autor: Jun-Tang Yang, Wen-Sheng Wang, Ya-Ru Wang, Qing-Hui Liu, Chao-Zhi Tang

Publikováno v: The FASEB Journal. 33:606-618

Depression represents a condition characterized by cognitive deficits and neural dysfunction and has recently been correlated with microRNAs (miRs) and their respective target genes. The present study was conducted with the goal of investigating the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf588f97a628e925991eb76c325bb7a
https://doi.org/10.1096/fj.201800210rr

LHX6, An Independent Prognostic Factor, Inhibits Lung Adenocarcinoma Progression through Transcriptional Silencing of β-catenin

Autor: Huidong Zhang, Xiao Jiang, Yongsheng Huang, Xiang-Lin Hao, Fei Han, Jia Cao, Jinyi Liu, Li Yin, Jun-Tang Yang, Ming-qian Zhang, Hongqiang Chen, Wen-bin Liu

Publikováno v: Journal of Cancer

Introduction: Our previous study identified LIM homeobox domain 6 (LHX6) as a frequently epigenetically silenced tumor-suppressor gene in lung cancer. However, its clinical value has never been evaluated, and the in-depth anti-tumor mechanism remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10caf9555687df2b8c5489fce039924f
https://doi.org/10.7150/jca.19972

ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway

Autor: Huidong Zhang, Fei Han, Li Yin, Wen-bin Liu, Hongqiang Chen, Xiang-Lin Hao, Yongsheng Huang, Jun-Tang Yang, Xiao Jiang, Jia Cao, Jinyi Liu

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-15 (2017)

Background ALX4 is a paired-like homedomain transcription factor mainly expressed in the mesenchymal compartment of variety of developing tissues, but its functions, regulation mechanisms and clinical values in breast cancer remains unclear. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c6bec88546c72610a149918a4c1ea6
http://europepmc.org/articles/PMC5706407

Up-regulated miR-192-5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2-mediated TGF-β1 signaling pathway.

Autor: Chao-Zhi Tang, Jun-Tang Yang, Qing-Hui Liu, Ya-Ru Wang, Wen-Sheng Wang

Publikováno v: FASEB Journal; Jan2019, Vol. 33 Issue 1, p606-618, 13p