Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Jun-Rong, Du"'
Publikováno v:
Journal of Integrative Neuroscience, Vol 22, Iss 4, p 92 (2023)
Introduction: Some studies have found that probiotics can improve cognitive impairment in Alzheimer’s disease, although the specific molecular mechanism by which this occurs has not been reported. Our previous research found that probiotics inhibit
Externí odkaz:
https://doaj.org/article/953c0124e7ae4527ba31b5095436c0f6
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Hemorrhagic transformation (HT) is a critical issue in thrombolytic therapy in acute ischemic stroke. Damage-associated molecular pattern (DAMP)-stimulated sterile neuroinflammation plays a crucial role in the development of throm
Externí odkaz:
https://doaj.org/article/f5ef4e5307be44229526b7418f467a07
Autor:
Hong-Jing Zhou, Hui Li, Meng-Qi Shi, Xiao-Na Mao, Dong-Ling Liu, Yi-Ran Chang, Yu-Miao Gan, Xi Kuang, Jun-Rong Du
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2018)
Aging is the greatest independent risk factor for the occurrence of stroke and poor outcomes, at least partially through progressive increases in oxidative stress and inflammation with advanced age. Klotho is an antiaging gene, the expression of whic
Externí odkaz:
https://doaj.org/article/09f2df0370c044aaac61a135cb4b251a
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Emerging evidence suggests that alpha-processing single transmembrane proteins, amyloid precursor protein (APP) and anti-aging protein Klotho, are likely to be involved in the progression of Alzheimer’s disease (AD). The natural phthalide Ligustili
Externí odkaz:
https://doaj.org/article/5569970dc273490cbb2204ccef3441d4
Publikováno v:
International immunopharmacology. 114
Prothrombotic and proinflammatory properties of neutrophil extracellular traps (NETs) contribute to brain damage after ischemic stroke. CD21 is a novel phthalide neuroprotectant against cerebral ischemia in rodents. This study investigated effects of
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:986-995
Objectives To explore the potential molecular mechanism underlying the effect of green tea extract (TE), rich in tea polyphenols (TPs), on improving alcohol-induced liver injury. Methods Mice were intragastrically treated with 50% (v/v) alcohol admin
Publikováno v:
The American Journal of Chinese Medicine. 49:505-523
Triple-negative breast cancer (TNBC) is the subtype of breast cancer with more aggressive growth and metastasis and without efficient therapies. Hence, it is worthwhile to search for potential effective drug candidates. According to our previous stud
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164586 (2016)
BACKGROUND:Peroxiredoxins (Prxs) are proposed to function as damage-associated molecular patterns (DAMPs) and contribute to post-ischemic neuroinflammation and brain injury by activating Toll-like receptor (TLR) 4 at the acute and subacute phases aft
Externí odkaz:
https://doaj.org/article/179bf585193546dc9ce2436df98910af
Autor:
Jing-Ying Li, Zi-Xing Zheng, Lin Liu, Ou Du, Neng-Wei Yu, Yunyun Zou, Seung-Yong Seong, Jun-Rong Du
Publikováno v:
International Immunopharmacology. 113:109330
Activation of the nuclear factor B (NF-κB) signaling pathway by pattern recognition receptors (PRRs) is regarded as a crucial mechanism of neuroinflammation and brain injury after acute ischemic stroke. The stimulation of alpha-kinase 1 (ALPK1), a n
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 475-487 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 475-487 (2020)
ProBiotic-4 is a probiotic preparation composed of Bifidobacterium lactis, Lactobacillus casei, Bifidobacterium bifidum, and Lactobacillus acidophilus. This study aims to investigate the effects of ProBiotic-4 on the microbiota–gut–brain axis and