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Akademický článek

Atroposelective Synthesis of Biaryl N‐Oxides via Cu‐Catalyzed De Novo Heteroaromatic N‐Oxide Ring Formation

Autor: Ke Ma, Ting Qi, Lei Hu, Chen Chen, Wan Wang, Jun‐Long Li, Cheng Peng, Gu Zhan, Bo Han

Publikováno v: Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)

Abstract Heteroaromatic N‐oxides, renowned for their highly polar N─O bond and robust structure, exhibit significant bioactivities and have played a pivotal role in various drug development projects since the discovery of Minoxidil. Moreover, het

Externí odkaz: https://doaj.org/article/b7c626486f754ce4b634582b60e09e2d

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Akademický článek

Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors

Autor: Zhen Dai, Wan-Cong Liu, Xiao-Yi Chen, Xiao Wang, Jun-Long Li, Xiang Zhang

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the c

Externí odkaz: https://doaj.org/article/26a6e0c50c314e7694450896d1d1f812

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Akademický článek

Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice

Autor: Lan Zhang, Yue Yang, Lei Di, Jun-long Li, Ning Li

Publikováno v: Pharmaceutical Biology, Vol 58, Iss 1, Pp 498-509 (2020)

Context In folk medicine, erxian decoction (EXD) is used to treat perimenopausal syndrome in women. It is also used clinically to treat depression, but the mechanism remains unknown. Objectives To investigate the neuroprotective effect of EXD, and it

Externí odkaz: https://doaj.org/article/f9de952bc6d64023b954cda7dab65301

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Akademický článek

Recent Advances in the Synthesis of Spiroheterocycles via N-Heterocyclic Carbene Organocatalysis

Autor: Yue Liu, Xiang Zhang, Rong Zeng, Ying Zhang, Qing-Song Dai, Hai-Jun Leng, Xiao-Jun Gou, Jun-Long Li

Publikováno v: Molecules, Vol 22, Iss 11, p 1882 (2017)

Spiroheterocycles are regarded as a privileged framework because of their wide distribution in various natural products and synthetic molecules and promising bioactivities. This review focuses on the recent advances in the synthesis of spiroheterocyc

Externí odkaz: https://doaj.org/article/d38d8ad7e81a40dba7345410952c0b8b

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Akademický článek

Diastereoselective Synthesis of Spirocyclopropanes under Mild Conditions via Formal [2 + 1] Cycloadditions Using 2,3-Dioxo-4-benzylidene-pyrrolidines

Autor: Yi Li, Qing-Zhu Li, Li Huang, Hong Liang, Kai-Chuan Yang, Hai-Jun Leng, Yue Liu, Xu-Dong Shen, Xiao-Jun Gou, Jun-Long Li

Publikováno v: Molecules, Vol 22, Iss 2, p 328 (2017)

A highly diastereoselective cyclopropanation of cyclic enones with sulfur ylides was developed under catalyst-free conditions, producing multifunctional spirocyclopropanes in generally excellent yields (up to 99% yield and >99:1 d.r.). The asymmetric

Externí odkaz: https://doaj.org/article/48e3f98ba046459fb20c8156f976c730

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