Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jun-Jie Gogo Liu"'
Autor:
Ao Sun, Cheng-Ping Li, Zhihang Chen, Shouyue Zhang, Dan-Yuan Li, Yun Yang, Long-Qi Li, Yuqian Zhao, Kaichen Wang, Zhaofu Li, Jinxia Liu, Sitong Liu, Jia Wang, Jun-Jie Gogo Liu
Publikováno v:
Cell Research. 33:229-244
CRISPR-Cas modules serve as the adaptive nucleic-acid immune systems for prokaryotes, and provide versatile tools for nucleic-acid manipulation in various organisms. Here, we discovered a new miniature type V system, CRISPR-Casπ (Cas12l) (∼860 aa)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e2e65c3553ece54984dc51d618b9c7
https://doi.org/10.1038/s41422-022-00771-2
https://doi.org/10.1038/s41422-022-00771-2
Publikováno v:
Chemical Science. 14:3839-3851
A positively-charged-residue enriched alpha helix in the REC2 domain serving as a conserved element to facilitate one-dimensional diffusion-driven target search of Cas12a and assisting target cleavage of AsCas12a.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ebb583d8d215eb47210988bca6b2d0f
https://doi.org/10.1039/d2sc05463a
https://doi.org/10.1039/d2sc05463a
Autor:
Pujuan Deng, Shun-Qing Tan, Qi-Yu Yang, Han-Zhou Zhu, Lei Sun, Zhangbin Bao, Yi Lin, Qiangfeng Cliff Zhang, Jia Wang, Jun-Jie Gogo Liu
SummaryRetroelements are the widespread jumping elements considered as major drivers for genome evolution, which can also be repurposed as gene-editing tools. Here, we determined the cryo-EM structures of eukaryotic R2 retrotransposon with ribosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bfabebae70f2aa27bbe61bdbbcc8157
https://doi.org/10.1101/2023.04.07.536001
https://doi.org/10.1101/2023.04.07.536001
Autor:
Zhian Hu, Ao Sun, Jinlei Yang, Gul Naz, Gongwei Sun, Zhengping Li, Jun-Jie Gogo Liu, Sichun Zhang, Xinrong Zhang
Publikováno v:
Chemical Science.
Methylation in the 5′ handle of gRNA disrupts the interaction between the Cas12a and gRNA. The deactivated CRISPR can be reactivated by demethylases, that enabled the development of biosensors and the precise regulation of gene expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7691d9ae2d3e9c7a1aa500d1dd9703af
https://doi.org/10.1039/d3sc00629h
https://doi.org/10.1039/d3sc00629h
Autor:
Xiaohui Kong, Kun Yan, Pujuan Deng, Haipeng Fu, Hongyao Sun, Wenze Huang, Shuangying Jiang, Junbiao Dai, Qiangfeng Cliff Zhang, Jun-jie Gogo Liu, Qiaoran Xi
Publikováno v:
Nucleic acids research. 50(18)
Transforming growth factor β (TGF-β) superfamily proteins are potent regulators of cellular development and differentiation. Nodal/Activin/TGF-β and BMP ligands are both present in the intra- and extracellular milieu during early development, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8e156d900950a752ea7bcd01f8fe05
https://pubmed.ncbi.nlm.nih.gov/36134711
https://pubmed.ncbi.nlm.nih.gov/36134711
Autor:
Pujuan Deng, Jun-Jie Gogo Liu
Publikováno v:
Nature Structural & Molecular Biology. 29:185-187
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e34e5f5be89176140afb98a592f68e
https://doi.org/10.1038/s41594-022-00744-4
https://doi.org/10.1038/s41594-022-00744-4
Autor:
Jun-Jie Gogo Liu, Chunlai Chen, Yuzhuo Yang, Pujuan Deng, Wenjuan Wang, Mengyi Yang, Ruirui Sun
Publikováno v:
Chemical Science
RNA-guided Streptococcus pyogenes Cas9 (SpCas9) is a sequence-specific DNA endonuclease that works as one of the most powerful genetic editing tools. However, how Cas9 locates its target among huge amounts of dsDNAs remains elusive. Here, combining b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681d3ba6f2fb53f8bee623beb1347fc3
http://europepmc.org/articles/PMC8494019
http://europepmc.org/articles/PMC8494019
Our mind can represent various objects from the physical world metaphorically into an abstract and complex high-dimensional object space, with a finite number of orthogonal axes encoding critical object features. Previous fMRI studies have shown that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ba46e07edfb43d2afcafed10768cd42
https://doi.org/10.1101/2021.09.28.462153
https://doi.org/10.1101/2021.09.28.462153
Autor:
Jun-Jie Gogo Liu, Ke Xu, Liangyi Chen, Rui Yan, Sai Li, Qiming Sun, Xinyu Ma, Shiqun Zhao, Shulin Li, Ying Li, Min Zhang, Jialu Xu, Liang Ge
Publikováno v:
Cell Res
Under stress, the endomembrane system undergoes reorganization to support autophagosome biogenesis, which is a central step in autophagy. How the endomembrane system remodels has been poorly understood. Here we identify a new type of membrane contact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e7b836550ed50d81ca08d36a0a49bf
https://doi.org/10.1101/2021.05.19.444771
https://doi.org/10.1101/2021.05.19.444771
Autor:
Connor A. Tsuchida, Shouyue Zhang, Mohammad Saffari Doost, Yuqian Zhao, Jia Wang, Elizabeth O’Brien, Huan Fang, Cheng-Ping Li, Danyuan Li, Zhuo-Yan Hai, Jonathan Chuck, Julian Brötzmann, Araz Vartoumian, David Burstein, Xiao-Wei Chen, Eva Nogales, Jennifer A. Doudna, Jun-Jie Gogo Liu
Publikováno v:
Molecular cell, vol 82, iss 6
Mol Cell
Mol Cell
A compact protein with a size of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c74e0d8fd86f98920edf6dcc0a0e24
https://doi.org/10.1016/j.molcel.2022.02.002
https://doi.org/10.1016/j.molcel.2022.02.002