Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jun-Ichi Sagara"'
Autor:
Shin Ono, Masato Koga, Yuya Arimura, Takahiro Hatakeyama, Mai Kobayashi, Jun-ichi Sagara, Takahiko Nakai, Yoshikazu Horino, Hirofumi Kuroda, Hiroshi Oyama, Kazunari Arima
Publikováno v:
Molecules, Vol 28, Iss 7, p 3150 (2023)
We previously reported that Lys175 in the region of the active site of chymotrypsin (Csin) could be site-selectively modified by using an N-hydroxy succinimide (NHS) ester of the peptidyl derivative containing 1-amino-2-ethylphenylphosphonate dipheny
Externí odkaz:
https://doaj.org/article/3553faefa8914ce1b193d91d3b2181a2
Autor:
Koutaro Yokote, Jun-ichi Sagara, Yoshiaki Hirayama, Kazuki Kobayashi, Hiroyuki Kurosawa, Masaya Koshizaka, Yoshiro Maezawa, Mayumi Shoji, Satoka Mori, Minoru Takemoto, Toshihiro Shoji, Kenichi Sakamoto, Takahiro Ishikawa
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Scientific Reports
Scientific Reports
Podocalyxin is a cell surface sialomucin, which is expressed in not only glomerular podocytes but also vascular endothelial cells. Urinary podocalyxin is used as a marker for glomerular disease. However, there are no reports describing serum podocaly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1eff3f3c57285d9d5a97ba28516d6f3
https://doi.org/10.1038/s41598-017-18647-6
https://doi.org/10.1038/s41598-017-18647-6
Publikováno v:
NeuroReport. 21:416-421
We examined the protective effects of N-acetylcysteine (NAC) on the death of glia-free neurons in culture. Under normoxic conditions, the protection by NAC was observed only in cystine-free but not complete medium. When the cells were cultured under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cefab8e25aab7562f97b3fec6003a6c
https://doi.org/10.1097/wnr.0b013e328337765c
https://doi.org/10.1097/wnr.0b013e328337765c
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1780:927-936
Oxidative stress is implicated in a variety of disorders including neurodegenerative diseases, and H 2 O 2 is important in the generation of reactive oxygen and oxidative stress. In this study, we have examined the rate of extracellular H 2 O 2 elimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efa0abf6b9e460fb68b48f38663c85a6
https://doi.org/10.1016/j.bbagen.2008.03.010
https://doi.org/10.1016/j.bbagen.2008.03.010
Autor:
Michiko Tamba, Naomichi Okamura, Nobuo Makino, Hideyo Sato, Jun-ichi Sagara, Yuki Sakakura, Manabu Matsuda, Ayako Shiiya, Shiro Bannai
Publikováno v:
Journal of Leukocyte Biology. 81:974-982
Reactive oxygen species (ROS) produced by neutrophils are essential in the host defense against infections but may be harmful to neutrophils themselves. Glutathione (GSH) plays a pivotal role in protecting cells against ROS-mediated oxidant injury. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0645d3ab0759a1243f96685f6f11fdea
https://doi.org/10.1189/jlb.0606385
https://doi.org/10.1189/jlb.0606385
Publikováno v:
Journal of Neurochemistry. 66:1876-1881
The characteristics and kinetics of GSH efflux from the monolayer culture of rat astrocytes were investigated. GSH efflux was dependent on temperature, with a Q 10 value of 2.0 between 37 and 25°C. The GSH efflux rate showed a hyperbolic dependency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcb41f2aac1a62b4706833749a2be7b
https://doi.org/10.1046/j.1471-4159.1996.66051876.x
https://doi.org/10.1046/j.1471-4159.1996.66051876.x
Autor:
Keiichi Kawai, Naoto Yamaguchi, Yuya Okui, Asuka Mizutani, Masato Ogura, Masato Kobayashi, Syuichi Nakajima, Naoto Shikano, Kentaro Kusanagi, Jun-ichi Sagara
Publikováno v:
Nuclear medicine and biology. 42(5)
Introduction Early detection and/or prediction of metastasis provide more prognostic relevance than local recurrence. Direct spread into the peritoneum is frequently found in pancreatic cancer patients, but positron emission tomography (PET) with 2-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1cb41aede578bbb0dcecb71b4dd15c
https://pubmed.ncbi.nlm.nih.gov/25725984
https://pubmed.ncbi.nlm.nih.gov/25725984
Autor:
Jun-ichi Sagara, Yoshiki Sugita
Publikováno v:
Brain Research. 902:190-197
To elucidate the contribution of glutathione S-transferase (GST) and glutathione peroxidase (GPx) to the protection against oxidative stress in rat brain, we prepared GST and GPx from newborn rat liver, brain and cultured astrocytes, and investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e647a3e3269bcb35eff9b6335d2a9949
https://doi.org/10.1016/s0006-8993(01)02384-8
https://doi.org/10.1016/s0006-8993(01)02384-8
Autor:
Jun-Ichi Sagara, Mitsunori Ikeguchi, Takeshi Kawabata, Kentaro Shimizu, Seishi Shimizu, Shugo Nakamura
Publikováno v:
Nucleic Acids Research. 26:1974-1979
We have developed a computational method that detects 'identities' in tRNA genes by using principal component analysis to classify the sequences of bases in tRNA genes into groups of similar sequences and then comparing the distribution of sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5923b6d1c0cb53a6dd976b27803874
https://doi.org/10.1093/nar/26.8.1974
https://doi.org/10.1093/nar/26.8.1974
Publikováno v:
Journal of biochemistry. 150(1)
Glutathione (GSH) plays an important neuroprotective role, and its synthesis depends on the amount of available cysteine (CSH) in the cells. Various kinds of evidence suggest that astrocytes can provide CSH or GSH to neurons, but the delivery mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ab3f8d3002cbee47ea18f90eaa476c
https://pubmed.ncbi.nlm.nih.gov/21436138
https://pubmed.ncbi.nlm.nih.gov/21436138