Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Jun-Ichi Hayashi"'
Autor:
Yoshihito Kishita, Kaori Ishikawa, Kazuto Nakada, Jun-Ichi Hayashi, Takuya Fushimi, Masaru Shimura, Masakazu Kohda, Akira Ohtake, Kei Murayama, Yasushi Okazaki
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract Leigh syndrome (LS) is an early-onset progressive neurodegenerative disorder associated with mitochondrial deficiency. m.14597A>G (p.Ile26Thr) in the MT-ND6 gene was reported to cause Leberʼs hereditary optic neuropathy (LHON) or dementia/d
Externí odkaz:
https://doaj.org/article/2a76a814c3ba4c25adefbc26eb47bb7d
Autor:
Chisato Sumi, Akihisa Okamoto, Hiromasa Tanaka, Kenichiro Nishi, Munenori Kusunoki, Tomohiro Shoji, Takeo Uba, Yoshiyuki Matsuo, Takehiko Adachi, Jun-Ichi Hayashi, Keizo Takenaga, Kiichi Hirota
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192796 (2018)
The intravenous anesthetic propofol (2,6-diisopropylphenol) has been used for the induction and maintenance of anesthesia and sedation in critical patient care. However, the rare but severe complication propofol infusion syndrome (PRIS) can occur, es
Externí odkaz:
https://doaj.org/article/78013698f7764b45b6a4255777243335
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118561 (2015)
We previously found that mouse mitochondrial DNA (mtDNA) with a G13997A mutation (G13997A mtDNA) controls not only the transformation of cultured lung carcinoma cells from poorly metastatic into highly metastatic cells, but also the transformation of
Externí odkaz:
https://doaj.org/article/ff74b90840824286a8f5a3048cfd5450
Autor:
Takayuki Mito, Yoshiaki Kikkawa, Akinori Shimizu, Osamu Hashizume, Shun Katada, Hirotake Imanishi, Azusa Ota, Yukina Kato, Kazuto Nakada, Jun-Ichi Hayashi
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55789 (2013)
Mitochondrial DNA (mtDNA) mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia) due to their carrying a nuclear-encoded mtDNA polymerase with a defective proofreading function, which causes accele
Externí odkaz:
https://doaj.org/article/26e751ffb9a34aad969369972af64f56
Autor:
Hirotake Imanishi, Gaku Takibuchi, Toshihiko Kobayashi, Kaori Ishikawa, Kazuto Nakada, Masayuki Mori, Yoshiaki Kikkawa, Keizo Takenaga, Noriko Toyama-Sorimachi, Jun-Ichi Hayashi
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75981 (2013)
In mammalian species, mitochondrial DNA (mtDNA) with pathogenic mutations that induce mitochondrial respiration defects has been proposed to be involved in tumor phenotypes via induction of enhanced glycolysis under normoxic conditions (the Warburg e
Externí odkaz:
https://doaj.org/article/3f956d1b06b14a1ea8aabea631650e76
Autor:
Kei Watanabe, Kenta Wada, Tomoko Ohashi, Saki Okubo, Kensuke Takekuma, Ryoichi Hashizume, Jun-Ichi Hayashi, Tadao Serikawa, Takashi Kuramoto, Yoshiaki Kikkawa
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50737 (2012)
We discovered a new cataract mutation, kfrs4, in the Kyoto Fancy Rat Stock (KFRS) background. Within 1 month of birth, all kfrs4/kfrs4 homozygotes developed cataracts, with severe opacity in the nuclei of the lens. In contrast, no opacity was observe
Externí odkaz:
https://doaj.org/article/32c5807dc6b440f4859c675debee5363
Autor:
Hirotake Imanishi, Keisuke Hattori, Reiko Wada, Kaori Ishikawa, Sayaka Fukuda, Keizo Takenaga, Kazuto Nakada, Jun-ichi Hayashi
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23401 (2011)
Mutations in mitochondrial DNA (mtDNA) might contribute to expression of the tumor phenotypes, such as metastatic potential, as well as to aging phenotypes and to clinical phenotypes of mitochondrial diseases by induction of mitochondrial respiration
Externí odkaz:
https://doaj.org/article/e48ab5ea89ea426abd8f6f6c11e142d6
Autor:
Liqin Cao, Hiroshi Shitara, Michihiko Sugimoto, Jun-Ichi Hayashi, Kuniya Abe, Hiromichi Yonekawa
Publikováno v:
PLoS Genetics, Vol 5, Iss 12, p e1000756 (2009)
In mammals, observations of rapid shifts in mitochondrial DNA (mtDNA) variants between generations have led to the creation of the bottleneck theory for the transmission of mtDNA. The bottleneck could be attributed to a marked decline of mtDNA conten
Externí odkaz:
https://doaj.org/article/90c0f44f1d2d4cbabc8776958be3d3fa
Autor:
Haruna Tani, Kaori Ishikawa, Hiroaki Tamashiro, Emi Ogasawara, Takehiro Yasukawa, Shigeru Matsuda, Akinori Shimizu, Dongchon Kang, Jun-Ichi Hayashi, Fan-Yan Wei, Kazuto Nakada
Publikováno v:
Nucleic Acids Research. 50:9382-9396
Mitochondrial tRNAs are indispensable for the intra-mitochondrial translation of genes related to respiratory subunits, and mutations in mitochondrial tRNA genes have been identified in various disease patients. However, the molecular mechanism under