Zobrazeno 1 - 10
of 5 381
pro vyhledávání: '"Jun-An Chen"'
Autor:
Xin Le Yap, Jun-An Chen
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 6, Pp 1263-1271 (2024)
Abstract MicroRNAs (miRNAs) are pivotal regulators of gene expression and are involved in biological processes spanning from early developmental stages to the intricate process of aging. Extensive research has underscored the fundamental role of miRN
Externí odkaz:
https://doaj.org/article/4f804fe9b0634ea7b2e32273d14e54cb
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109207- (2024)
Summary: Long noncoding RNAs (lncRNAs) play pivotal roles in modulating gene expression during development and disease. Despite their high expression in the central nervous system (CNS), understanding the precise physiological functions of CNS-associ
Externí odkaz:
https://doaj.org/article/5ba128b0932a4fbbb8e2614925283f42
Autor:
Tai-Heng Chen, Shih-Hsin Chang, Yu-Fu Wu, Ya-Ping Yen, Fang-Yu Hsu, Yen-Chung Chen, Yang Ming, Ho-Chiang Hsu, Yi-Ching Su, Sheng-Tang Wong, Jui-Hung Hung, Shih-Hwa Chiou, Yuh-Jyh Jong, Jun-An Chen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 144-160 (2023)
Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by the selective loss of spinal motor neurons (MNs) and concomitant muscle weakness. Mutation of SMN1 is known to cause SMA, and restoring SMN protein levels via antisense oli
Externí odkaz:
https://doaj.org/article/420741cfadc04cd1856eed780b37a795
Autor:
Ee Shan Liau, Suoqin Jin, Yen-Chung Chen, Wei-Szu Liu, Maëliss Calon, Stéphane Nedelec, Qing Nie, Jun-An Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
How molecular diversity in neurons links to versatile functions is elusive. Here the authors profiled embryonic spinal motor neurons with single-cell RNAseq and identified molecular subtypes targeting distinct muscle groups in different species.
Externí odkaz:
https://doaj.org/article/8fb774de0a664ae0ba23e11ff25a0f8e
Autor:
Qing Ma, Liuyi Yang, Karen Tolentino, Guiping Wang, Yang Zhao, Ulrike M Litzenburger, Quanming Shi, Lin Zhu, Chen Yang, Huiyuan Jiao, Feng Zhang, Rui Li, Miao-Chih Tsai, Jun-An Chen, Ian Lai, Hong Zeng, Lingjie Li, Howard Y Chang
Publikováno v:
eLife, Vol 11 (2022)
HOTAIR is a 2.2-kb long noncoding RNA (lncRNA) whose dysregulation has been linked to oncogenesis, defects in pattern formation during early development, and irregularities during the process of epithelial-to-mesenchymal transition (EMT). However, th
Externí odkaz:
https://doaj.org/article/741109f2ea6440da9dc2a4c9fc75863e
Autor:
Ya-Ping Yen, Jun-An Chen
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-11 (2021)
Abstract N 6-methyladenosine (m6A) is the most prevalent, conserved, and abundant RNA modification of the mRNAs of most eukaryotes, including mammals. Similar to epigenetic DNA modifications, m6A has been proposed to function as a critical regulator
Externí odkaz:
https://doaj.org/article/a9fccd9533be4ac69870c4ae8317a873
Autor:
Kuan-Wei Chen, Jun-An Chen
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-14 (2020)
Abstract Long non-coding RNAs (lncRNAs) have gained increasing attention as they exhibit highly tissue- and cell-type specific expression patterns. LncRNAs are highly expressed in the central nervous system and their roles in the brain have been stud
Externí odkaz:
https://doaj.org/article/344b71d019034df68512f584254ce648
Autor:
Chung‐Jung Li, Ee Shan Liau, Yi‐Han Lee, Yang‐Zhe Huang, Ziyi Liu, Andrew Willems, Victoria Garside, Edwina McGlinn, Jun‐An Chen, Tian Hong
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 4, Pp n/a-n/a (2021)
Abstract Positive feedback driven by transcriptional regulation has long been considered a key mechanism underlying cell lineage segregation during embryogenesis. Using the developing spinal cord as a paradigm, we found that canonical, transcription
Externí odkaz:
https://doaj.org/article/41afa7d3db8c48f1941a4a3e0a07bcb4
Publikováno v:
eLife, Vol 10 (2021)
Although the function of microRNAs (miRNAs) during embryonic development has been intensively studied in recent years, their postnatal physiological functions remain largely unexplored due to inherent difficulties with the presence of redundant paral
Externí odkaz:
https://doaj.org/article/93a456670f544ba48285e8b6c83f2485
Autor:
Ya-Ping Yen, Wen-Fu Hsieh, Ya-Yin Tsai, Ya-Lin Lu, Ee Shan Liau, Ho-Chiang Hsu, Yen-Chung Chen, Ting-Chun Liu, Mien Chang, Joye Li, Shau-Ping Lin, Jui-Hung Hung, Jun-An Chen
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/4eb2f61fc5a546f599d8647489104910