Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jun ichiro Enmi"'
Autor:
Yuka Yoshino, Yuta Fujii, Kazuhiro Chihara, Aya Nakae, Jun-ichiro Enmi, Yoshichika Yoshioka, Izuru Miyawaki
Publikováno v:
Toxicology Reports, Vol 12, Iss , Pp 1-9 (2024)
Drug-induced steatohepatitis is considered more serious than drug-induced hepatic steatosis, so that differentiating between the two is crucial in drug development. In addition, early detection of drug-induced steatohepatitis is considered important
Externí odkaz:
https://doaj.org/article/d3fe9ac1385942c88e0bb95af9ef75d6
Autor:
Yuka Yoshino, Yuta Fujii, Kazuhiro Chihara, Aya Nakae, Jun-ichiro Enmi, Yoshichika Yoshioka, Izuru Miyawaki
Publikováno v:
Toxicology Reports, Vol 10, Iss , Pp 481-486 (2023)
No method of monitoring drug-induced hepatic steatosis has been established, which is a concern in drug development. Hepatic steatosis is divided into diffuse and non-diffuse forms according to the pattern of fat deposition. Diffuse hepatic steatosis
Externí odkaz:
https://doaj.org/article/a62356ed7679451786ca40cbc0c7c706
Autor:
Yuta Fujii, Yuka Yoshino, Kazuhiro Chihara, Aya Nakae, Jun-ichiro Enmi, Yoshichika Yoshioka, Izuru Miyawaki
Publikováno v:
Toxicology Reports, Vol 10, Iss , Pp 97-103 (2023)
There are no specific and sensitive biomarkers for arteritis, and the occurrence of arteritis in nonclinical toxicological studies of a candidate drug makes development of the drug very difficult. However, we showed in a previous study that the high
Externí odkaz:
https://doaj.org/article/7b724274792644abb74bfb7db292f600
Autor:
Yuta Fujii, Yuka Yoshino, Kazuhiro Chihara, Aya Nakae, Jun-ichiro Enmi, Yoshichika Yoshioka, Izuru Miyawaki
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 1595-1602 (2022)
A method capable of identifying drug-induced arteritis is highly desirable because no specific and sensitive biomarkers have yet been defined. Although magnetic resonance imaging (MRI) may be used to find a biomarker candidate for drug-induced arteri
Externí odkaz:
https://doaj.org/article/09f847ecd7ad4334bd6e543eb6c78d90
Autor:
Takaaki Morimoto, Jun-ichiro Enmi, Yorito Hattori, Satoshi Iguchi, Satoshi Saito, Kouji H. Harada, Hiroko Okuda, Yohei Mineharu, Yasushi Takagi, Shohab Youssefian, Hidehiro Iida, Susumu Miyamoto, Masafumi Ihara, Hatasu Kobayashi, Akio Koizumi
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract RNF213 is a susceptibility gene for moyamoya disease, yet its exact functions remain unclear. To evaluate the role of RNF213 in adaptation of cerebral blood flow (CBF) under cerebral hypoperfusion, we performed bilateral common carotid arter
Externí odkaz:
https://doaj.org/article/b969cc437d5b4540ab0359356b4517d8
Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans
Autor:
Yorito Hattori, Jun‐ichiro Enmi, Satoshi Iguchi, Satoshi Saito, Yumi Yamamoto, Masahiro Tsuji, Kazuyuki Nagatsuka, Rajesh N. Kalaria, Hidehiro Iida, Masafumi Ihara
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 2 (2016)
BackgroundExisting rodent models of vascular cognitive impairment (VCI) show abrupt changes in cerebral blood flow (CBF) and do not reliably replicate the clinical pathogenesis of VCI. We therefore aimed to develop a mouse model of VCI where CBF is g
Externí odkaz:
https://doaj.org/article/827a1375c19d442ba5b69d5549dcc7eb
Autor:
Gen Yamada, Kentaro Suzuki, Alvin R. Acebedo, Mizuki Kajimoto, Taiju Hyuga, Yoshichika Yoshioka, Daiki Hashimoto, Shinichi Miyagawa, Jun ichiro Enmi
Publikováno v:
Differentiation. 110:29-35
Development of external genitalia (ExG) has been a topic of long mystery in the field of organogenesis research. Early stage male and female of mouse embryos develop a common genital tubercle (GT) in the perineum whose outgrowth extends distally from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b738fe8b56a384a769f83da3ec7de3
https://doi.org/10.1016/j.diff.2019.08.004
https://doi.org/10.1016/j.diff.2019.08.004
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
Understanding cerebral oxygen metabolism is of great importance in both clinical diagnosis and animal experiments because oxygen is a fundamental source of brain energy and supports brain functional activities. Since small animals such as rats are wi
Externí odkaz:
https://doaj.org/article/e216544aa56b48cf8b4b86222fa4e1f5
Autor:
Qiang Zhao, Hiroji Yanamoto, Keiko Yamato, Hiroharu Kataoka, Hidehiro Iida, Jun-ichiro Enmi, Yukako Nakajo, Jun Takahashi
Publikováno v:
Molecular Neurobiology. 56:658-670
Prolongation of the T2 relaxation time, an increase in T2-weighted signal intensity (T2-SI), and a decrease in the apparent diffusion coefficient (ADC) calculated from diffusion-weighted images (DWI) on magnetic resonance imaging (MRI) are convention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b652eeb26f05a43afff82251e96522
https://doi.org/10.1007/s12035-018-1073-1
https://doi.org/10.1007/s12035-018-1073-1
Autor:
Daizo Ishii, Jun-ichiro Enmi, Takeshi Moriwaki, Hastue Ishibashi-Ueda, Mari Kobayashi, Shinichi Iwana, Hidehiro Iida, Tetsu Satow, Jun C. Takahashi, Kaoru Kurisu, Yasuhide Nakayama
Publikováno v:
Journal of Artificial Organs. 19:262-269
Biotubes, i.e., in vivo tissue-engineered connective tubular tissues, are known to be effective as vascular replacement grafts with a diameter greater than several millimeters. However, the performance of biotubes with smaller diameters is less clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671bba35d47f32e9400e719258dffec0
https://doi.org/10.1007/s10047-016-0894-9
https://doi.org/10.1007/s10047-016-0894-9