Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Jun Yamanouchi"'
Autor:
Javier Montaño, Josep Garnica, Jun Yamanouchi, Joel Moro, Patricia Solé, Debajyoti Mondal, Pau Serra, Yang Yang, Pere Santamaria
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Unlike conventional CD4+ T cells, which are phenotypically and functionally plastic, invariant NKT (iNKT) cells generally exist in a terminally differentiated state. Naïve CD4+ T cells can acquire alternative epigenetic states in response to differe
Externí odkaz:
https://doaj.org/article/d950d79cdab34b9f8c4189885955f874
Autor:
Daisuke Hiraoka, Jun Ishizaki, Jun Yamanouchi, Takatsugu Honda, Toshiyuki Niiya, Erika Horimoto, Kenta Horie, Hitoshi Yamasaki, Takuya Matsumoto, Koichiro Suemori, Hitoshi Hasegawa, Katsuto Takenaka
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss 2 (2024)
Objectives Hydroxychloroquine (HCQ) has been shown to reduce thrombotic events in patients with SLE. However, the antiplatelet effects of HCQ are only supported by the platelet aggregation assay, which is a non-physiological test. The total thrombus-
Externí odkaz:
https://doaj.org/article/9b2b82fe11bb48f18f153048a308cfff
Autor:
Yuji Kashiwakura, Nemekhbayar Baatartsogt, Shoji Yamazaki, Azusa Nagao, Kagehiro Amano, Nobuaki Suzuki, Tadashi Matsushita, Akihiro Sawada, Satoshi Higasa, Naoya Yamasaki, Teruhisa Fujii, Taemi Ogura, Hideyuki Takedani, Masashi Taki, Takeshi Matsumoto, Jun Yamanouchi, Michio Sakai, Masako Nishikawa, Yutaka Yatomi, Koji Yada, Keiji Nogami, Ryota Watano, Takafumi Hiramoto, Morisada Hayakawa, Nobuhiko Kamoshita, Akihiro Kume, Hiroaki Mizukami, Shizukiyo Ishikawa, Yoichi Sakata, Tsukasa Ohmori
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 404-414 (2022)
Adeno-associated virus (AAV) vectors are promising modalities of gene therapy to address unmet medical needs. However, anti-AAV neutralizing antibodies (NAbs) hamper the vector-mediated therapeutic effect. Therefore, NAb prevalence in the target popu
Externí odkaz:
https://doaj.org/article/b43dde9c693b47fc933baa57f7dd8461
Autor:
Channakeshava Sokke Umeshappa, Patricia Solé, Jun Yamanouchi, Saswat Mohapatra, Bas G. J. Surewaard, Josep Garnica, Santiswarup Singha, Debajyoti Mondal, Elena Cortés-Vicente, Charlotte D’Mello, Andrew Mason, Paul Kubes, Pau Serra, Yang Yang, Pere Santamaria
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Invariant natural killer T (iNKT) cells are tissue-resident immune cells recognizing lipid antigens. Here the authors find that liver, but not lung nor spleen, iNKT cells alter their transcriptome upon systemic treatment of lipid nanoparticles for th
Externí odkaz:
https://doaj.org/article/85b3165ec41e474c9dabb9f4fe3fa4b0
Autor:
Patricia Solé, Daniel Parras, Jun Yamanouchi, Josep Garnica, Nahir Garabatos, Joel Moro, Javier Montaño, Debajyoti Mondal, César Fandos, Yang Yang, Pau Serra, Pere Santamaria
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Systemic delivery of nanoparticles (NPs) coated with mono-specific autoimmune disease-relevant peptide-major histocompatibility complex class II (pMHCII) molecules can resolve organ inflammation in various disease models in a disease-specific manner
Externí odkaz:
https://doaj.org/article/85c9e4b9a8e44dcfae571bff682908fe
Autor:
Shun-ichi Kimura, Yoshinobu Kanda, Masaki Iino, Takahiro Fukuda, Emiko Sakaida, Tatsuo Oyake, Hiroki Yamaguchi, Shin-ichiro Fujiwara, Yumi Jo, Akinao Okamoto, Hiroyuki Fujita, Yasushi Takamatsu, Yoshio Saburi, Itaru Matsumura, Jun Yamanouchi, Souichi Shiratori, Moritaka Gotoh, Shingen Nakamura, Kazuo Tamura
Publikováno v:
International Journal of Infectious Diseases, Vol 100, Iss , Pp 292-297 (2020)
Objectives: The D-index is defined as the area over the neutrophil curve during neutropenia. The CEDMIC trial confirmed the noninferiority of D-index-guided early antifungal therapy (DET) using micafungin to empirical antifungal therapy (EAT). In thi
Externí odkaz:
https://doaj.org/article/56f4329c4ebd413babece8f6dcdd5914
Autor:
Pau Serra, Nahir Garabatos, Santiswarup Singha, César Fandos, Josep Garnica, Patricia Solé, Daniel Parras, Jun Yamanouchi, Jesús Blanco, Meritxell Tort, Mireia Ortega, Yang Yang, Kristofor K. Ellestad, Pere Santamaria
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Recombinant MHC class II molecules are instrumental in antigen-specific T-cell identification assays and showed efficacy as experimental medicines. Here, the authors engineer MHC class II molecules with species-specific knob-into-hole heteromerizatio
Externí odkaz:
https://doaj.org/article/7ee67d52977841a9b1785048df8248f6
Autor:
Channakeshava Sokke Umeshappa, Santiswarup Singha, Jesus Blanco, Kun Shao, Roopa Hebbandi Nanjundappa, Jun Yamanouchi, Albert Parés, Pau Serra, Yang Yang, Pere Santamaria
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Immune response against tissue-specific antigens is a hallmark of autoimmunity. Here the authors show that a single autoantigen-based nanomedicine can ameliorate pathology in a broad range of liver autoimmunity models without impairing host defenses,
Externí odkaz:
https://doaj.org/article/d597958e29974428be28085b0fd4c0ca
Autor:
Channakeshava Sokke Umeshappa, Patricia Solé, Bas G.J. Surewaard, Jun Yamanouchi, Saswat Mohapatra, Muhammad Myn Uddin, Robert Clarke, Mireia Ortega, Santiswarup Singha, Debajyoti Mondal, Yang Yang, Dario A.A. Vignali, Pau Serra, Paul Kubes, Pere Santamaria
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108919- (2021)
Summary: Neutrophils with immunoregulatory properties, also referred to as type-2 neutrophils (N2), myeloid-derived suppressor cells (MDSCs), or tumor-associated neutrophils (TANs), comprise a heterogeneous subset of cells that arise from unknown pre
Externí odkaz:
https://doaj.org/article/059a5f0cfc094d07bb42d1671b8d8c6c
Autor:
Shinji Hasebe, Keiko Tanaka, Yoshihiro Miyake, Hiroaki Asai, Kazuto Takeuchi, Tomomi Fujii, Hitoshi Kawazoe, Kazushi Tanimoto, Jun Yamanouchi, Taichi Azuma, Masaki Yasukawa, Yoshihiro Yakushijin
Publikováno v:
International Journal of Gerontology, Vol 12, Iss 2, Pp 100-104 (2018)
Summary: Background: The prognosis of diffuse large B-cell lymphoma (DLBCL) is remarkably improved after R-CHOP therapy. However, there are few detailed reports regarding very elderly DLBCL patients. We investigated relationships between prognostic f
Externí odkaz:
https://doaj.org/article/d64df2c8f2fb4f38b591956ae60da26f