Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Jun Xu Li"'
Autor:
Lulu Yu, Xunjia Qian, Yiheng Feng, Yujian Yin, Xiao-Dan Zhang, Qianqian Wei, Liyun Wang, Weiwei Rong, Jie-Jia Li, Jun-Xu Li, Qing Zhu
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
N- Demethylsinomenine (NDSM), the in vivo demethylated metabolite of sinomenine, has exhibited antinociceptive efficacy against various pain models and may become a novel drug candidate for pain management. However, no reported analytical method for
Externí odkaz:
https://doaj.org/article/c4f11532f2f644cdb8a6928b77cf08e3
Autor:
Jennifer A. Martin, Craig T. Werner, Swarup Mitra, Ping Zhong, Zi-Jun Wang, Pedro H. Gobira, Andrew. F. Stewart, Jay Zhang, Kyra Erias, Justin N. Siemian, Devin Hagarty, Lauren E. Mueller, Rachael L. Neve, Jun-Xu Li, Ramesh Chandra, Karen C. Dietz, Mary Kay Lobo, Amy M. Gancarz, Zhen Yan, David M. Dietz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The underlying transcriptional and cellular events mediating the reduction of dendritic spines on medium spiny neurons of the nucleus accumbens (NAc) remains unknown. Here, authors demonstrate that heroin self-administration negatively regulates the
Externí odkaz:
https://doaj.org/article/fd3986183cd145e696e221b400cee251
Autor:
Ming-Cong Zheng, Wen-Ting Tang, Lu-Lu Yu, Xun-Jia Qian, Jie Ren, Jie-Jia Li, Wei-Wei Rong, Jun-Xu Li, Qing Zhu
Publikováno v:
Molecules, Vol 27, Iss 11, p 3570 (2022)
Oxypeucedanin, a furanocoumarin extracted from many traditional Chinese herbal medicines, has a variety of pharmacological effects. However, the independent pharmacokinetic characteristics and bioavailability of this compound remains elusive. In this
Externí odkaz:
https://doaj.org/article/28cdf669548641a2a32547c4af2965ff
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The emphasis of neuronal alterations and adaptations have long been the main focus of the studies of the mechanistic underpinnings of drug addiction. Recent studies have begun to appreciate the role of innate immune system, especially toll-like recep
Externí odkaz:
https://doaj.org/article/0640e40d6b2c4cf7b40a3aa21f092cd0
Autor:
Hong-Bin Luo, Nan Shang, Wen-Zhi Xie, De-Jian Wen, Min Qu, Sheng Huang, Sha-Sha Fan, Wei Chen, Nan-Qiao Mou, Xiang-Yu Liu, Qin Chen, Feng-Feng Xie, Jun-Xu Li
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 5, Pp 915-922 (2018)
Large-scale epidemiological studies have found that hyperhomocysteinemia is a powerful, independent risk factor for Alzheimer’s disease. Trillium tschonoskii maxim is a traditional Chinese medicine that is used to promote memory. However, scientifi
Externí odkaz:
https://doaj.org/article/90d9859dad2041eeb5a9b5ba25c0fce7
Autor:
Xunjia Qian, Xinyi Zhao, Lulu Yu, Yujian Yin, Xiao-Dan Zhang, Liyun Wang, Jialie Luo, Jun-Xu Li, Qing Zhu
Gamma-aminobutyric acid (GABA), a non-protein-producing amino acid, is extensively found in microorganisms, plants and vertebrates, and is abundantly expressed in the spinal cord and brain. To date, GABA is considered to be the major inhibitory neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::378453d8a04d333ef39b5d40b7cfe95d
https://doi.org/10.20944/preprints202305.1444.v1
https://doi.org/10.20944/preprints202305.1444.v1
Publikováno v:
Brain Behav Immun
Opioid addiction remains a severe health problem. While substantial insights underlying opioid addiction have been yielded from neuron-centric studies, the contribution of non-neuronal mechanisms to opioid-related behavioral adaptations has begun to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018fcdc149cdc7c13b0e3496f11e3c12
https://doi.org/10.1016/j.bbi.2021.12.014
https://doi.org/10.1016/j.bbi.2021.12.014
Publikováno v:
ACS Chemical Neuroscience.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed188cf2868319ccf1e1783adc6f9c17
https://doi.org/10.1021/acschemneuro.2c00689
https://doi.org/10.1021/acschemneuro.2c00689
Autor:
Jian-Feng Liu, Jun-Xu Li
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Trace-amine associated receptor 1 (TAAR1) is the best-characterized member of the family of TAARs. TAAR1 is broadly expressed in the brain, especially within the monoaminergic systems. Evidence from electrophysiological and neurochemical studies eval
Externí odkaz:
https://doaj.org/article/ac12527b5c6f4a5e86b80d4c1d07122f
Publikováno v:
CNS Drugs
Trace amines, including β-phenylethylamine (β-PEA), p-tyramine (TYR), tryptamine (TRP) and p-octopamine (OCT), represent a group of amines expressed at low levels in the mammalian brain. Given the close structural similarities to traditional monoam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff2c4e5254d2d7afaee51fbb7bafb30
https://doi.org/10.1007/s40263-021-00871-4
https://doi.org/10.1007/s40263-021-00871-4