Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jun Wei Pek"'
Autor:
Jun Wei Pek, Amanda Yunn Ee Ng
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114303- (2024)
Investigator Jun Wei Pek (J.P.) and graduate student Amanda Yunn Ee Ng (A.Y.) spoke to Cell Reports about their scientific journeys and love of science, their work on gene expression regulation during reproductive development, and challenges encounte
Externí odkaz:
https://doaj.org/article/f2648c119ee04e94b2258b56aa2da03c
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Mitochondria are inherited exclusively from the mothers and are required for the proper development of embryos. Hence, germline mitochondrial quality is highly regulated during oogenesis to ensure oocyte viability. How nutrient availability
Externí odkaz:
https://doaj.org/article/1973431e7a664a1ca437a8a3f257d802
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114228- (2024)
Summary: Inter-regulation between related genes, such as ribosomal protein (RP) paralogs, has been observed to be important for genetic compensation and paralog-specific functions. However, how paralogs communicate to modulate their expression levels
Externí odkaz:
https://doaj.org/article/5f9b7571fb8f4a70b217ad599b8ec167
Autor:
Kelly Voo, Jeralyn Wen Hui Ching, Joseph Wee Hao Lim, Seow Neng Chan, Amanda Yunn Ee Ng, Jasmine Yi Ying Heng, Shiao See Lim, Jun Wei Pek
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009932 (2021)
Organisms adapt to environmental changes in order to survive. Mothers exposed to nutritional stresses can induce an adaptive response in their offspring. However, the molecular mechanisms behind such inheritable links are not clear. Here we report th
Externí odkaz:
https://doaj.org/article/e0bb08d7c32c44a7a78da455c7fb1f76
Publikováno v:
Stem Cell Reports, Vol 11, Iss 1, Pp 13-21 (2018)
Summary: Adult and embryonic stem cells exhibit fluctuating gene expression; however, the biological significance of stem cell heterogeneity is not well understood. We show that, in Drosophila, female germline stem cells (GSCs) exhibit heterogeneous
Externí odkaz:
https://doaj.org/article/17edc1655c484eea9035ba1044fe8584
Autor:
Ismail Osman, Jun Wei Pek
Publikováno v:
Stem Cell Reports, Vol 11, Iss 1, Pp 4-12 (2018)
Summary: Animal reproduction responds to nutritional status. During starvation, Drosophila and Caenorhabditis elegans enter a period of reproductive diapause with increase apoptosis, while maintaining a stable pool of germline stem cells (GSCs). How
Externí odkaz:
https://doaj.org/article/63f05470edb241b6a3a8c8927ca08bbd
Publikováno v:
iScience, Vol 4, Iss , Pp 68-75 (2018)
Summary: Although stable intronic sequence RNAs (sisRNAs) are conserved in plants and animals, their functional significance is still unclear. We identify a pool of polyadenylated maternally deposited sisRNAs in Drosophila melanogaster. These sisRNAs
Externí odkaz:
https://doaj.org/article/7f785dd2e7474360942b7fa4f17033ab
Autor:
Jing Ting Wong, Farzanah Akhbar, Amanda Yunn Ee Ng, Mandy Li-Ian Tay, Gladys Jing En Loi, Jun Wei Pek
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Stable intronic sequence RNAs (sisRNAs) are by-products of splicing from introns with roles in embryonic development in Drosophila. Here, the authors show that the RNA binding protein DIP1 regulates sisRNAs in Drosophila, which is necessary for germl
Externí odkaz:
https://doaj.org/article/f5b9004081984bb9a7ce59a01c81c533
Autor:
Mandy Li-Ian Tay, Jun Wei Pek
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008498 (2019)
Gene expression involves the transcription and splicing of nascent transcripts through the removal of introns. In Drosophila, a double-stranded RNA binding protein Disco-interacting protein 1 (DIP1) targets INE-1 stable intronic sequence RNAs (sisRNA
Externí odkaz:
https://doaj.org/article/40447161917042cabc086251e5302d69
Autor:
Ling-Ling Chen, Albrecht Bindereif, Irene Bozzoni, Howard Y. Chang, A. Gregory Matera, Myriam Gorospe, Thomas B. Hansen, Jørgen Kjems, Xu-Kai Ma, Jun Wei Pek, Nikolaus Rajewsky, Julia Salzman, Jeremy E. Wilusz, Li Yang, Fangqing Zhao
Publikováno v:
Nature Cell Biology. 25:1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef811c3aa24b49c1cff22a4c4bb40524
https://doi.org/10.1038/s41556-022-01066-9
https://doi.org/10.1038/s41556-022-01066-9