Výsledky vyhledávání - "Jun Sunayama"

Crosstalk Between the PI3K/mTOR and MEK/ERK Pathways Involved in the Maintenance of Self-Renewal and Tumorigenicity of Glioblastoma Stem-Like Cells

Autor: Soichiro Shibui, Kenichiro Matsuda, Ken Tachibana, Chifumi Kitanaka, Kaori Sakurada, Jun Sunayama, Kaori Suzuki, Arata Tomiyama, Takamasa Kayama, Atsushi Sato, Yoshitaka Narita

Publikováno v: Stem Cells. 28:1930-1939

The molecular signaling pathways orchestrating the biology of cancer stem-like cells (CSLCs), including glioblastoma, remain to be elucidated. We investigated in this study the role of the MEK/extracellular signal-regulated kinase (ERK) pathway in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f34ffb8485daaf9b7b21305b81e914e
https://doi.org/10.1002/stem.521

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Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells

Autor: Jun Sunayama, Kenichiro Matsuda, Kaori Suzuki, Atsushi Sato, Arata Tomiyama, Kaori Sakurada, Ken Tachibana, Chifumi Kitanaka, Soichiro Shibui, Yoshitaka Narita, Takamasa Kayama

Publikováno v: Neuro-Oncology. 12:1205-1219

Glioblastoma, the most intractable cerebral tumor, is highly lethal. Recent studies suggest that cancer stem-like cells (CSLCs) have the capacity to repopulate tumors and mediate radio- and chemoresistance, implying that future therapies may need to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59d0feaa137851e80a4fca410ed4576
https://doi.org/10.1093/neuonc/noq103

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Regulation of neural stem/progenitor cell maintenance by PI3K and mTOR

Autor: Ken Tachibana, Atsushi Sato, Kaori Sakurada, Chifumi Kitanaka, Jun Sunayama, Takamasa Kayama, Arata Tomiyama, Kenichiro Matsuda

Publikováno v: Neuroscience Letters. 470:115-120

Control of stem cell state and differentiation of neural stem/progenitor cells is essential for proper development of the nervous system. EGF and FGF2 play important roles in the control of neural stem/progenitor cells, but the underlying mechanism s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0081bf37bf9474ba9af0bdec31537fdc
https://doi.org/10.1016/j.neulet.2009.12.067

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JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3

Autor: Jun Sunayama, Fuminori Tsuruta, Norihisa Masuyama, Yukiko Gotoh

Publikováno v: The Journal of Cell Biology

Life and death decisions are made by integrating a variety of apoptotic and survival signals in mammalian cells. Therefore, there is likely to be a common mechanism that integrates multiple signals adjudicating between the alternatives. In this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173c3971b0388cb00ed96811c09e71db
https://doi.org/10.1083/jcb.200409117

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A Cellular Mechanism That Reversibly Inactivates Pancaspase Inhibitor zAsp-CH2-DCB: A Potential Pitfall Causing Discrepancy between in Vitro and in Vivo Caspase Assays

Autor: Akiko Kokubu, Takamasa Kayama, Jun Sunayama, Yoshiyuki Kuchino, Chifumi Kitanaka, Arata Tomiyama, Kaori Sakurada

Publikováno v: Biochemical and Biophysical Research Communications. 291:1022-1030

Cell-permeable pancaspase inhibitors such as zAsp-CH2-DCB and zVAD-fmk are widely used to examine the involvement of caspases in cell death models. While examining the caspase-dependence of staurosporine (STS)-induced neuroblastoma cell death, we fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4739d5b30ce664b3c870e3ac974141
https://doi.org/10.1006/bbrc.2002.6560

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Glioma-Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK

Autor: Yoshitaka Narita, Soichiro Shibui, Atsushi Sato, Chifumi Kitanaka, Kaori Suzuki, Masashi Okada, Shizuka Seino, Jun Sunayama, Takamasa Kayama, Eriko Watanabe, Keita Shibuya

Control of the cancer stem/initiating cell population is considered key to realizing the long-term survival of glioblastoma patients. Recently, we demonstrated that FOXO3 activation is sufficient to induce differentiation of glioma-initiating cells h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001226a1a6bb7cd31f1c881b0f3f1f65
https://europepmc.org/articles/PMC3659661/

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FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity

Autor: Kenichiro Matsuda, Ken Tachibana, Jun Sunayama, Chifumi Kitanaka, Shizuka Seino, Takamasa Kayama, Yoshitaka Narita, Arata Tomiyama, Atsushi Sato, Kaori Suzuki, Eriko Watanabe, Kaori Sakurada, Soichiro Shibui

Publikováno v: Stem cells (Dayton, Ohio). 29(9)

Glioblastoma is one of the most aggressive types of human cancer, with invariable and fatal recurrence even after multimodal intervention, for which cancer stem-like cells (CSLCs) are now being held responsible. Our recent findings indicated that com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b7e8e5f509644c2943ae32308d3239
https://pubmed.ncbi.nlm.nih.gov/21793107

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MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death

Autor: Jun Sunayama, Kenji Nemoto, Nomiya T, Shizuka Seino, Hidetoshi Yamashita, Arata Tomiyama, Yoshitaka Matsumoto, Atsushi Sato, Kenichiro Matsuda, Kyoko Suzuki, Takamasa Kayama, Ken Tachibana, Chifumi Kitanaka, Ando K

Publikováno v: Cell Death & Disease

Recently developed heavy ion irradiation therapy using a carbon beam (CB) against systemic malignancy has numerous advantages. However, the clinical results of CB therapy against glioblastoma still have room for improvement. Therefore, we tried to cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c678923764ee6d154ecd2329fe5f7b3
https://pubmed.ncbi.nlm.nih.gov/21364665

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Downregulation of Ras C-terminal processing by JNK inhibition

Autor: Kaori Sakurada, Arata Tomiyama, Ken Tachibana, Wataru Mouri, Jun Sunayama, Chifumi Kitanaka, Takamasa Kayama, Atsushi Sato

Publikováno v: Biochemical and biophysical research communications. 371(2)

After translation, Ras proteins undergo a series of modifications at their C-termini. This post-translational C-terminal processing is essential for Ras to become functional, but it remains unknown whether and how Ras C-terminal processing is regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b5991df6ab7c37176f438bce284747
https://pubmed.ncbi.nlm.nih.gov/18435909

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Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32

Autor: Kaori Sakurada, Fumio Tashiro, Dongchon Kang, Yukiko Gotoh, Yoshiyuki Kuchino, Jun Sunayama, Chifumi Kitanaka, Arata Tomiyama, N Itoh, Akinori Sugiyama, Y Ando

Publikováno v: Cell death and differentiation. 11(7)

Bcl-2 homology domain (BH) 3-only proteins of the proapoptotic Bcl-2 subfamily play a key role as initiators of mitochondria-dependent apoptosis. To date, at least 10 mammalian BH3-only proteins have been identified, and it is now being realized that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9adb286e723bf916c446077fb213f7
https://pubmed.ncbi.nlm.nih.gov/15031724

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