Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jun Shi Chang"'
Publikováno v:
ACS Central Science, Vol 9, Iss 11, Pp 2150-2160 (2023)
Externí odkaz:
https://doaj.org/article/58e522cc16f844b5b8811192f9978df9
Publikováno v:
Organic letters. 24(43)
A strategy for the synthesis of de novo discovered lactazole-like thiopeptides is reported. The approach revolves around a convergent and scalable preparation of the central triheterocyclic amino acid and its utilization in Fmoc solid-phase peptide s
Autor:
Alexander A. Vinogradov, Yue Zhang, Keisuke Hamada, Jun Shi Chang, Chikako Okada, Hirotaka Nishimura, Naohiro Terasaka, Yuki Goto, Kazuhiro Ogata, Toru Sengoku, Hiroyasu Onaka, Hiroaki Suga
Publikováno v:
Journal of the American Chemical Society. 144(44)
Bioengineering of ribosomally synthesized and post-translationally modified peptides (RiPPs) is an emerging approach to explore the diversity of pseudo-natural product structures for drug discovery purposes. However, despite the initial advances in t
Autor:
Kakeru Narumi, Hiroyasu Onaka, Yuki Goto, Jun Shi Chang, Alexander A. Vinogradov, Emiko Nagai, Hiroaki Suga
Publikováno v:
Journal of the American Chemical Society. 142:20329-20334
We report a method for the high-throughput reactivity profiling of genetically encoded libraries as a tool to study substrate fitness landscapes for RiPP (ribosomally synthesized and post-translationally modified peptide) biosynthetic enzymes. This m