Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jun Seop Yun"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Although protein–protein interactions (PPIs) have emerged as the basis of potential new therapeutic approaches, targeting intracellular PPIs with small molecule inhibitors is conventionally considered highly challenging. Driven by increasi
Externí odkaz:
https://doaj.org/article/d4b406ee4e724930b430cee4e2117dfb
Autor:
Seonghun Kim, Cheol-Hee Jeong, Sang Hyun Song, Jo Eun Um, Hyun Sil Kim, Jun Seop Yun, Dawool Han, Eunae Sandra Cho, Bo Young Nam, Jong In Yook, Minhee Ku, Jaemoon Yang, Man-Deuk Kim, Nam Hee Kim, Tae-Hyun Yoo
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Tubulointerstitial renal fibrosis is a chronic disease process affecting chronic kidney disease (CKD). While the etiological role of transforming growth factor-beta (TGF-β) is well known for epithelial–mesenchymal transition (EMT) in chronic kidne
Externí odkaz:
https://doaj.org/article/291e68acb87e446ab909fda7a1ff3097
Autor:
Yoonmi Lee, Nam Hee Kim, Eunae Sandra Cho, Ji Hye Yang, Yong Hoon Cha, Hee Eun Kang, Jun Seop Yun, Sue Bean Cho, Seon-Hyeong Lee, Petra Paclikova, Tomasz W. Radaszkiewicz, Vitezslav Bryja, Chi Gu Kang, Young Soo Yuk, So Young Cha, Soo-Youl Kim, Hyun Sil Kim, Jong In Yook
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Hippo and Wnt pathways are important for cancer development, and they can cross talk; however, the mechanisms behind this connection are unknown. Here the authors show that DVL (a scaffold protein in the Wnt pathway) regulates the shuttling of YAP (a
Externí odkaz:
https://doaj.org/article/5664ab6c4abb4c098757cecb0a32f56a
Autor:
Nam Hee Kim, Sang Hyun Song, Yun Hee Choi, Kyu Ho Hwang, Jun Seop Yun, Hyeeun Song, So Young Cha, Sue Bean Cho, Inhan Lee, Hyun Sil Kim, Jong In Yook
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9589 (2021)
The epithelial-mesenchymal transition (EMT) comprises an important biological mechanism not only for cancer progression but also in the therapeutic resistance of cancer cells. While the importance of the protein abundance of EMT-inducers, such as Sna
Externí odkaz:
https://doaj.org/article/62f1c1ab2f754a8c91625060cce30d17
Autor:
Hee Eun Kang, Yoojeong Seo, Jun Seop Yun, Sang Hyun Song, Dawool Han, Eunae Sandra Cho, Sue Bean Cho, Yoon Jeon, Ho Lee, Hyun Sil Kim, Joyeon Kang, Jong In Yook, Nam Hee Kim, Tae Il Kim
Publikováno v:
Cancers, Vol 13, Iss 14, p 3437 (2021)
The Wnt and Hippo pathways are tightly coordinated and understanding their reciprocal regulation may provide a novel therapeutic strategy for cancer. Anti-helminthic niclosamide is an effective inhibitor of Wnt and is now in a phase II trial for adva
Externí odkaz:
https://doaj.org/article/7ef8c6f285d44153adae3b6cdba0d15b
Autor:
Jiwon Choi, Jun Seop Yun, Hyeeun Song, Yong-Keol Shin, Young-Hoon Kang, Palinda Ruvan Munashingha, Jeongyeon Yoon, Nam Hee Kim, Hyun Sil Kim, Jong In Yook, Dongseob Tark, Yun-Sook Lim, Soon B. Hwang
Publikováno v:
Molecules, Vol 26, Iss 12, p 3592 (2021)
African swine fever virus (ASFV) causes a highly contagious and severe hemorrhagic viral disease with high mortality in domestic pigs of all ages. Although the virus is harmless to humans, the ongoing ASFV epidemic could have severe economic conseque
Externí odkaz:
https://doaj.org/article/a2188459c33244ccad12c0afbaa8a58d
Autor:
Nam Hee Kim, Yong Hoon Cha, Jueun Lee, Seon-Hyeong Lee, Ji Hye Yang, Jun Seop Yun, Eunae Sandra Cho, Xianglan Zhang, Miso Nam, Nami Kim, Young-Su Yuk, So Young Cha, Yoonmi Lee, Joo Kyung Ryu, Sunghyouk Park, Jae-Ho Cheong, Sang Won Kang, Soo-Youl Kim, Geum-Sook Hwang, Jong In Yook, Hyun Sil Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Cancer cell survival under metabolic stress is a critical step for metastasis. Here, the authors show that under glucose deprivation, Snail, a key regulator of the metastatic process, promotes survival by diverting glucose to the pentose phosphate pa
Externí odkaz:
https://doaj.org/article/54773ae57086423bbfe78d47470a22d6
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9138 (2020)
Fibrosis is presented in various physiologic and pathologic conditions of the salivary gland. Transforming growth factor beta (TGF-β) pathway has a pivotal role in the pathogenesis of fibrosis in several organs, including the salivary glands. Among
Externí odkaz:
https://doaj.org/article/3d8b86520568479fa9057b6aa4841799
Publikováno v:
Cells, Vol 9, Iss 9, p 2064 (2020)
Efficient catabolic metabolism of adenosine triphosphate (ATP) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) is essentially required for cancer cell survival, especially in metastatic cancer progression. Epithelial–mesenchymal tra
Externí odkaz:
https://doaj.org/article/dcfa570883a94936b481bcdad5707d12
Autor:
Jun Seop Yun, Hyeeun Song, Nam Hee Kim, So Young Cha, Kyu Ho Hwang, Jae Eun Lee, Cheol-Hee Jeong, Sang Hyun Song, Seonghun Kim, Eunae Sandra Cho, Hyun Sil Kim, Jong In Yook
Publikováno v:
Molecules and Cells. 45:911-922
A structural protein of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), nucleocapsid (N) protein is phosphorylated by glycogen synthase kinase (GSK)-3 on the serine/arginine (SR) rich motif located in disordered regions. Although phosph