Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Jun S. Liu"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract TWAS have shown great promise in extending GWAS loci to a functional understanding of disease mechanisms. In an effort to fully unleash the TWAS and GWAS information, we propose MTWAS, a statistical framework that partitions and aggregates c
Externí odkaz:
https://doaj.org/article/7375bb35adf9483684114e62d5660b97
Autor:
Chen-Hao Chen, Rongbin Zheng, Collin Tokheim, Xin Dong, Jingyu Fan, Changxin Wan, Qin Tang, Myles Brown, Jun S. Liu, Clifford A. Meyer, X. Shirley Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Characterization of the distance over which TF binding influences gene expression is important for inferring target genes. Here the authors study this relationship using thousands of genomic data sets, finding two classes of TFs with distinct ranges
Externí odkaz:
https://doaj.org/article/78325609a2444fecaf9d8aaf4a86bf49
Publikováno v:
Environmental Data Science, Vol 1 (2022)
Reconstructing past climate events relies on the relevant proxies and how they are related. Depending only on such relationships, however, could not be robust because only few proxy observations are usually available at each age. A state-space model
Externí odkaz:
https://doaj.org/article/200fdb8cbc0f4e50b22bc8f350b517c0
Publikováno v:
Royal Society Open Science, Vol 8, Iss 8 (2021)
Cooperation is one of the key collective behaviours of human society. Despite discoveries of several social mechanisms underpinning cooperation, relatively little is known about how our neural functions affect cooperative behaviours. Here, we study t
Externí odkaz:
https://doaj.org/article/267ab9f2be2540618a0f30a24125f136
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract A major goal of metagenomics is to identify and study the entire collection of microbial species in a set of targeted samples. We describe a statistical metagenomic algorithm that simultaneously identifies microbial species and estimates the
Externí odkaz:
https://doaj.org/article/f0473b5ef87f44c594224ca35cc641dd
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-5 (2017)
Externí odkaz:
https://doaj.org/article/17b0f36f33d44a34b9ab4d96734a00f1
Autor:
Chongzhi Zang, Tao Wang, Ke Deng, Bo Li, Sheng’en Hu, Qian Qin, Tengfei Xiao, Shihua Zhang, Clifford A. Meyer, Housheng Hansen He, Myles Brown, Jun S. Liu, Yang Xie, X. Shirley Liu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Analyses of data from high-throughput genomic technologies are challenging given large data dimensionality. Here, Liu and colleagues describe a method called MANCIE (Matrix Analysis and Normalization by Concordant Information Enhancement) that can co
Externí odkaz:
https://doaj.org/article/aa14d67d31a54ea9b4ff50393da16654
Publikováno v:
Entropy, Vol 22, Iss 3, p 291 (2020)
Traditional hypothesis-margin researches focus on obtaining large margins and feature selection. In this work, we show that the robustness of margins is also critical and can be measured using entropy. In addition, our approach provides clear mathema
Externí odkaz:
https://doaj.org/article/78cfc3cd33934c3ab4551dffe592a8fc
Autor:
Junjie Lu, Hu Li, Ming Hu, Takayo Sasaki, Anna Baccei, David M. Gilbert, Jun S. Liu, James J. Collins, Paul H. Lerou
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 70-78 (2014)
Cell-fate change involves significant genome reorganization, including changes in replication timing, but how these changes are related to genetic variation has not been examined. To study how a change in replication timing that occurs during reprogr
Externí odkaz:
https://doaj.org/article/f22cd49a205d42bea871fc2318ab3275
Publikováno v:
Statistica Sinica.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d94b86d70b2c12c39756a4195653bc9
https://doi.org/10.5705/ss.202022.0141
https://doi.org/10.5705/ss.202022.0141