Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Jun S Wei"'
Autor:
Olga Kim, Zach Sergi, Guangyang Yu, Kazutoshi Yamamoto, Martha Quezado, Zied Abdullaev, Danel R. Crooks, Shun Kishimoto, Qi Li, Peng Lu, Burchelle Blackman, Thorkell Andresson, Xiaolin Wu, Bao Tran, Jun S. Wei, Wei Zhang, Meili Zhang, Hua Song, Javed Khan, Murali C. Krishna, Jeffrey R. Brender, Jing Wu
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Malignant transformation (MT) is commonly seen in IDH-mutant gliomas. There has been a growing research interest in revealing its underlying mechanisms and intervening prior to MT at the early stages of the transforming process. Here we esta
Externí odkaz:
https://doaj.org/article/4b329e13fa87456ea2628bbe4d0bfe40
Autor:
Meijie Tian, Jun S. Wei, Adam Tai-Chi Cheuk, David Milewski, Zhongmei Zhang, Yong Yean Kim, Hsien-Chao Chou, Can Liu, Sherif Badr, Eleanor G. Pope, Abdelrahman Rahmy, Jerry T. Wu, Michael C. Kelly, Xinyu Wen, Javed Khan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Chimeric antigen receptor (CAR) T-cells targeting Fibroblast Growth Factor Receptor 4 (FGFR4), a highly expressed surface tyrosine receptor in rhabdomyosarcoma (RMS), are already in the clinical phase of development, but tumour heterogeneity
Externí odkaz:
https://doaj.org/article/a3964d3bf8e04e298aea51cf07822727
Autor:
Li Chen, Jack F Shern, Jun S Wei, Marielle E Yohe, Young K Song, Laura Hurd, Hongling Liao, Daniel Catchpoole, Stephen X Skapek, Frederic G Barr, Douglas S Hawkins, Javed Khan
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005075 (2015)
To infer the subclonality of rhabdomyosarcoma (RMS) and predict the temporal order of genetic events for the tumorigenic process, and to identify novel drivers, we applied a systematic method that takes into account germline and somatic alterations i
Externí odkaz:
https://doaj.org/article/df4d2ffc7ee84072a7cc3f1788b039bb
Autor:
Andrew S Brohl, David A Solomon, Wendy Chang, Jianjun Wang, Young Song, Sivasish Sindiri, Rajesh Patidar, Laura Hurd, Li Chen, Jack F Shern, Hongling Liao, Xinyu Wen, Julia Gerard, Jung-Sik Kim, Jose Antonio Lopez Guerrero, Isidro Machado, Daniel H Wai, Piero Picci, Timothy Triche, Andrew E Horvai, Markku Miettinen, Jun S Wei, Daniel Catchpool, Antonio Llombart-Bosch, Todd Waldman, Javed Khan
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004475 (2014)
The Ewing sarcoma family of tumors (EFT) is a group of highly malignant small round blue cell tumors occurring in children and young adults. We report here the largest genomic survey to date of 101 EFT (65 tumors and 36 cell lines). Using a combinati
Externí odkaz:
https://doaj.org/article/7422003c4829425facb07fc765958f49
Autor:
Yong Yean Kim, Berkley E. Gryder, Ranuka Sinniah, Megan L. Peach, Jack F. Shern, Abdalla Abdelmaksoud, Silvia Pomella, Girma M. Woldemichael, Benjamin Z. Stanton, David Milewski, Joseph J. Barchi, John S. Schneekloth, Raj Chari, Joshua T. Kowalczyk, Shilpa R. Shenoy, Jason R. Evans, Young K. Song, Chaoyu Wang, Xinyu Wen, Hsien-Chao Chou, Vineela Gangalapudi, Dominic Esposito, Jane Jones, Lauren Procter, Maura O’Neill, Lisa M. Jenkins, Nadya I. Tarasova, Jun S. Wei, James B. McMahon, Barry R. O’Keefe, Robert G. Hawley, Javed Khan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 are lacking. Here, we screen 62,643 compounds using an engineered cell
Externí odkaz:
https://doaj.org/article/62fcc583cb83489ca474d4e078b73633
Autor:
Samuel Q Li, Adam T Cheuk, Jack F Shern, Young K Song, Laura Hurd, Hongling Liao, Jun S Wei, Javed Khan
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76551 (2013)
Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. Despite advances in modern therapy, patients with relapsed or metastatic disease have a very poor clinical prognosis. Fibroblast Growth Factor Receptor 4 (FGFR4) is a cell surfa
Externí odkaz:
https://doaj.org/article/1bbef48c06684f579976e41dcdf4feaa
Autor:
Belhu Metaferia, Jun S Wei, Young K Song, Jennifer Evangelista, Konrad Aschenbach, Peter Johansson, Xinyu Wen, Qingrong Chen, Albert Lee, Heidi Hempel, Jinesh S Gheeya, Stephanie Getty, Romel Gomez, Javed Khan
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e58870 (2013)
Peptide nucleic acids (PNAs) have gained much interest as molecular recognition tools in biology, medicine and chemistry. This is due to high hybridization efficiency to complimentary oligonucleotides and stability of the duplexes with RNA or DNA. We
Externí odkaz:
https://doaj.org/article/61046825f21e4bb3b8d4b5128a781261
Autor:
Jun S Wei, Peter Johansson, Li Chen, Young K Song, Catherine Tolman, Samuel Li, Laura Hurd, Rajesh Patidar, Xinyu Wen, Thomas C Badgett, Adam T C Cheuk, Jean-Claude Marshall, Patricia S Steeg, José P Vaqué Díez, Yanlin Yu, J Silvio Gutkind, Javed Khan
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77731 (2013)
Neuroblastoma is one of the most genomically heterogeneous childhood malignances studied to date, and the molecular events that occur during the course of the disease are not fully understood. Genomic studies in neuroblastoma have showed only a few r
Externí odkaz:
https://doaj.org/article/bfd95a4fdc5045e0a93c5c2253919e54
Autor:
Jesus Gonzalez-Bosquet, Jacob Calcei, Jun S Wei, Montserrat Garcia-Closas, Mark E Sherman, Stephen Hewitt, Joseph Vockley, Jolanta Lissowska, Hannah P Yang, Javed Khan, Stephen Chanock
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14522 (2011)
Identification of somatic mutations in cancer is a major goal for understanding and monitoring the events related to cancer initiation and progression. High resolution melting (HRM) curve analysis represents a fast, post-PCR high-throughput method fo
Externí odkaz:
https://doaj.org/article/0b219cc392fb496f992a46ca70e857cd
Autor:
Meijie Tian, Adam T. Cheuk, Jun S. Wei, Abdalla Abdelmaksoud, Hsien-Chao Chou, David Milewski, Michael C. Kelly, Young K. Song, Christopher M. Dower, Nan Li, Haiying Qin, Yong Yean Kim, Jerry T. Wu, Xinyu Wen, Mehdi Benzaoui, Katherine E. Masih, Xiaolin Wu, Zhongmei Zhang, Sherif Badr, Naomi Taylor, Brad St. Croix, Mitchell Ho, Javed Khan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
Chimeric antigen receptor (CAR) T cell therapies targeting single antigens have performed poorly in clinical trials for solid tumors due to heterogenous expression of tumor-associated antigens (TAAs), limited T cell persistence, and T cell exhaustion
Externí odkaz:
https://doaj.org/article/114fac18c13d4632b85c061e52d66443