Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Jun O, Liu"'
Autor:
Ping Zhu, Shi-You Li, Jin Ding, Zhou Fei, Sheng-Nan Sun, Zhao-Hui Zheng, Ding Wei, Jun Jiang, Jin-Lin Miao, San-Zhong Li, Xing Luo, Kui Zhang, Bin Wang, Kun Zhang, Su Pu, Qian-Ting Wang, Xin-Yue Zhang, Gao-Liu Wen, Jun O. Liu, John Thomas August, Huijie Bian, Zhi-Nan Chen, You-Wen He
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 6, Pp 616-624 (2023)
Glioblastoma (GBM) is a lethal cancer with limited therapeutic options. Dendritic cell (DC)-based cancer vaccines provide a promising approach for GBM treatment. Clinical studies suggest that other immunotherapeutic agents may be combined with DC vac
Externí odkaz:
https://doaj.org/article/38ec1a088c2841dabe8481860dfceee9
Autor:
He Fang, Xingtong Wang, Mahendra Damarla, Rongju Sun, Qingli He, Ruojing Li, Pengfei Luo, Jun O. Liu, Zhaofan Xia
Publikováno v:
Mediators of Inflammation, Vol 2023 (2023)
Sepsis is one of the most severe complications and causes of mortality in the clinic. It remains a great challenge with no effective treatment for clinicians worldwide. Inhibiting the release of proinflammatory cytokines during sepsis is considered a
Externí odkaz:
https://doaj.org/article/d8b0f382743a4722b4a140d20d69ea8a
Autor:
Liyun Zhang, Conan Chen, Jie Fu, Brendan Lilley, Cynthia Berlinicke, Baranda Hansen, Ding Ding, Guohua Wang, Tao Wang, Daniel Shou, Ying Ye, Timothy Mulligan, Kevin Emmerich, Meera T Saxena, Kelsi R Hall, Abigail V Sharrock, Carlene Brandon, Hyejin Park, Tae-In Kam, Valina L Dawson, Ted M Dawson, Joong Sup Shim, Justin Hanes, Hongkai Ji, Jun O Liu, Jiang Qian, David F Ackerley, Baerbel Rohrer, Donald J Zack, Jeff S Mumm
Publikováno v:
eLife, Vol 10 (2021)
Retinitis pigmentosa (RP) and associated inherited retinal diseases (IRDs) are caused by rod photoreceptor degeneration, necessitating therapeutics promoting rod photoreceptor survival. To address this, we tested compounds for neuroprotective effects
Externí odkaz:
https://doaj.org/article/ae361e62a3fd4acc8161a7ed3eae9011
Autor:
Emmanuel Datan, Il Minn, Peng Xu, Qing-Li He, Hye-Hyun Ahn, Biao Yu, Martin G. Pomper, Jun O. Liu
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101536- (2020)
Summary: A major hurdle in the treatment of cancer is chemoresistance induced under hypoxia that is characteristic of tumor microenvironment. Triptolide, a potent inhibitor of eukaryotic transcription, possesses potent antitumor activity. However, it
Externí odkaz:
https://doaj.org/article/33df17c77b184861b71368215af366fc
Publikováno v:
J Am Chem Soc
A pharmacophore-directed retrosynthetic (PDR) strategy was applied to the first total synthesis of the cembranoid, rameswaralide, in order to simultaneously achieve a total synthesis while also developing a structure-activity relationship profile thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5548e14c168ff45bcc7b32d6e04d103
https://doi.org/10.1021/jacs.2c08245
https://doi.org/10.1021/jacs.2c08245
Autor:
Donald Small, Jun O. Liu, Mark J. Levis, Tomoyasu Higashimoto, Li Li, Bao Nguyen, David J. Young
Validation cohort patient characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ec4684be404e7e6d1c69af387c79ab
https://doi.org/10.1158/2643-3230.22543425.v1
https://doi.org/10.1158/2643-3230.22543425.v1
Autor:
Donald Small, Jun O. Liu, Mark J. Levis, Tomoyasu Higashimoto, Li Li, Bao Nguyen, David J. Young
FMS-like tyrosine kinase 3 (FLT3) is the most frequently mutated gene in acute myeloid leukemia and a target for tyrosine kinase inhibitors (TKI). FLT3 TKIs have yielded limited improvements to clinical outcomes. One reason for this is TKI inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d37aa9e1dd55371945e7a22739bf2f8
https://doi.org/10.1158/2643-3230.c.6550254.v1
https://doi.org/10.1158/2643-3230.c.6550254.v1
Autor:
Donald Small, Jun O. Liu, Mark J. Levis, Tomoyasu Higashimoto, Li Li, Bao Nguyen, David J. Young
Mathematical treatment of drug-protein interactions and supplementary figures 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538d8be3eb3f51e004a4145be67a67ca
https://doi.org/10.1158/2643-3230.22543428
https://doi.org/10.1158/2643-3230.22543428
Autor:
Elizabeth A. Platz, Angelo M. De Marzo, William G. Nelson, William B. Isaacs, Charles G. Drake, Ian M. Thompson, M. Scott Lucia, Catherine M. Tangen, Phyllis J. Goodman, Kathryn B. Arnold, Michael T. Marrone, Jun O. Liu, Fan Pan, Ines Benedetti, Javier A. Baena Del Valle, Berrak Gumuskaya, Ibrahim Kulac, Lauren M. Hurwitz
Aspirin and statin use may lower the risk of advanced/fatal prostate cancer, possibly by reducing intraprostatic inflammation. To test this hypothesis, we investigated the association of aspirin and statin use with the presence and extent of intrapro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5442fe5f5fc7a74055539f37a8b99449
https://doi.org/10.1158/1940-6207.c.6547319.v1
https://doi.org/10.1158/1940-6207.c.6547319.v1
Autor:
William B. Isaacs, Martin G. Pomper, Jun O. Liu, Ronnie C. Mease, Benjamin A. Nacev, Haofan Wang, Brice A.P. Wilson
Supplementary Materials, Figures 1-7, Tables 1-2 from High-Throughput Screen Identifies Novel Inhibitors of Cancer Biomarker α-Methylacyl Coenzyme A Racemase (AMACR/P504S)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d427ba9f72e936277e6934026799ffa
https://doi.org/10.1158/1535-7163.22497162
https://doi.org/10.1158/1535-7163.22497162