Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jun Nishiu"'
Autor:
Chihiro Okuma, Takeshi Ohta, Hironobu Tadaki, Tatsuya Ishigure, Shohei Sakata, Hideyuki Taniuchi, Ryuhei Sano, Hiromi Hamada, Shinichi Kume, Jun Nishiu, Makoto Kakutani
Publikováno v:
Journal of Pharmacological Sciences, Vol 128, Iss 3, Pp 150-157 (2015)
Aim: Monoacyglycerol acyltransferases (MGATs) are known to play important roles in intestinal TG absorption. In contrast, the role of MGATs in the liver is still unclear. We investigated the effects of JTP-103237, a novel MGAT inhibitor, on hepatic M
Externí odkaz:
https://doaj.org/article/4f84e16fc93843638e297033bf9858ca
Autor:
Chihiro Okuma, Takeshi Ohta, Makoto Ito, Hironobu Tadaki, Tomohiro Oda, Shinichi Kume, Jun Nishiu, Makoto Kakutani
Publikováno v:
Journal of Pharmacological Sciences, Vol 130, Iss 2, Pp 136-138 (2016)
Some nutrients, such as carbohydrate, fat and protein, are known to stimulate satiety. However, the effect of sn-2-monoacylglycerol (2-MG), one of the digestive products of triglycerides, on food intake is still unclear. In the present study, the eff
Externí odkaz:
https://doaj.org/article/75e71d1997c94870b15a717a96be6fdf
Autor:
Takeshi Ohta, Hideyuki Taniuchi, Tatsuya Ishigure, Jun Nishiu, Hiromi Hamada, Ryuhei Sano, Hironobu Tadaki, Chihiro Okuma, Shinichi Kume, Shohei Sakata, Makoto Kakutani
Publikováno v:
Journal of Pharmacological Sciences, Vol 128, Iss 3, Pp 150-157 (2015)
Aim Monoacyglycerol acyltransferases (MGATs) are known to play important roles in intestinal TG absorption. In contrast, the role of MGATs in the liver is still unclear. We investigated the effects of JTP-103237, a novel MGAT inhibitor, on hepatic MG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a761b08b0090e5a61333f3e2ee70290
https://doi.org/10.1016/j.jphs.2015.06.007
https://doi.org/10.1016/j.jphs.2015.06.007
Autor:
Makoto Kakutani, Tomohiro Oda, Makoto Ito, Takeshi Ohta, Hironobu Tadaki, Shinichi Kume, Chihiro Okuma, Jun Nishiu
Publikováno v:
Journal of Pharmacological Sciences, Vol 130, Iss 2, Pp 136-138 (2016)
Some nutrients, such as carbohydrate, fat and protein, are known to stimulate satiety. However, the effect of sn-2-monoacylglycerol (2-MG), one of the digestive products of triglycerides, on food intake is still unclear. In the present study, the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835df4b300950edd9c07bbe02fe4fb39
http://hdl.handle.net/2433/218473
http://hdl.handle.net/2433/218473
Autor:
Marc Learned, Steven M. Rubenstein, Juan C. Jaen, Hisashi Shinkai, Jun Nishiu, Holger Beckmann, Alykhan Motani, Jin-Long Chen, Yuki Kitao, Lawrence R. McGee, Martin Thoolen, Patrick C. Kearney, Yang Li, Atsushi Hagiwara, Jinsong Liu, Guosen Ye, Michelle Lindstrom, Timothy D. Cushing, Joshua Taygerly, John A. Flygare, Nigel Walker, Jennifer Weiszmann, Tetsuya Iida, Walter P. Frankmoelle, Zhulun Wang, Shichang Miao, Hisateru Aramaki, Pieter B. M. W. M. Timmermans, Noboru Furukawa, Jonathan B. Houze, Donna H.T. Biermann, Motonao Nakamura
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:979-992
PPARγ is a member of the nuclear hormone receptor family and plays a key role in the regulation of glucose homeostasis. This Letter describes the discovery of a novel chemical class of diarylsulfonamide partial agonists that act as selective PPARγ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdec54bdc6f85c8e2a8785ec784731f5
https://doi.org/10.1016/j.bmc.2012.11.058
https://doi.org/10.1016/j.bmc.2012.11.058
Autor:
Shinichi Kume, Jun Nishiu, Yasuhiro Ohe, Shinji Yata, Hiromi Hamada, Shin-ichi Oshida, Kenji Yamanaka, Yukihito Ishii, Makoto Kakutani, Hideyuki Taniuchi, Yusuke Aratsu, Hironobu Tadaki, Chihiro Okuma, Takeshi Ohta, Tomohiro Oda
Publikováno v:
European journal of pharmacology. 758
Monoacylglycerol acyltransferase 2 (MGAT2) plays an important role in intestinal fat absorption. We discovered the novel MGAT2 inhibitor, JTP-103237, and evaluated its pharmacological profile. JTP-103237 selectively inhibited MGAT2 without remarkable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da9f9f0e7446f145f91820263459325
https://pubmed.ncbi.nlm.nih.gov/25857225
https://pubmed.ncbi.nlm.nih.gov/25857225
Autor:
Shohei Sakata, Tohru Komano, Jun Nishiu, Hiroshi Sakai, Noriyuki Kioka, Takashi Fukada, Masayasu Yamada
Publikováno v:
FEBS Letters. 436:228-232
We found that there are at least five subclasses of N-acetylglucosaminyltransferase I (GnT-I; EC 2.4.1.101) mRNA with different 5′-untranslated regions in rat brain. These five subclasses were also expressed in many tissues with distinct tissue-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab728ae160b612230aa1eae36b1c2615
https://doi.org/10.1016/s0014-5793(98)01136-3
https://doi.org/10.1016/s0014-5793(98)01136-3
Autor:
Takuya Orita, Jun Nishiu, Toshihiro Tanaka, Makoto Itoh, Yusuke Nakamura, Shuichi Tsukada, Hitonobu Tomoike
Publikováno v:
Journal of Human Genetics. 43:9-13
To achieve a better understanding of the mechanism of intimal thickening, we used a rabbit model in which aorta was denuded mechanically by a balloon catheter. Total RNA was prepared from each aorta 1, 2, 7, 14, 23, or 30 days after denudation, and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef479b6cec98cfc576300faa25097edc
https://doi.org/10.1007/s100380050030
https://doi.org/10.1007/s100380050030
Autor:
Masatsugu Horiuchi, Jun Nishiu, Masaru Iwai, Shuichi Tsukada, Toshihiro Tanaka, Makoto Itoh, Yusuke Nakamura, Hitonobu Tomoike
Publikováno v:
Circulation. 107(2)
Background— Vascular restenosis attributable to intimal thickening remains a major problem after percutaneous transluminal coronary angioplasty (PTCA). Methods and Results— Through differential-display analysis, we have identified a novel gene wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a0610050c879cc31ef3c6d0278cac5
https://pubmed.ncbi.nlm.nih.gov/12538434
https://pubmed.ncbi.nlm.nih.gov/12538434
Publikováno v:
Genomics. 52(3)
We isolated by the differential display technique a novel gene that was expressed abundantly in adipose and female-specific tissues. The cDNA contained an open reading frame of 2097 nucleotides encoding a 699-amino-acid peptide. The predicted protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a6671b876810fb063db0d13538b27e
https://pubmed.ncbi.nlm.nih.gov/9790758
https://pubmed.ncbi.nlm.nih.gov/9790758