Výsledky vyhledávání

Autor: Yoshihiko Kotake, Naoki Asai, Yoshio Fukuda, Takashi Sakai, Jun Niijima, Taisuke Uehara

Publikováno v: The Journal of Antibiotics. 60:364-369

Pladienolide B is a 12-membered macrolide isolated from Streptomyces platensis Mer-11107. It showed potent in vitro and in vivo antitumor activities and is a potential lead for novel antitumor agents. The absolute configurations at ten chiral centers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7176c10d9c7ed13bfdbfddca8ab3fb41
https://doi.org/10.1038/ja.2007.49

Zobrazit plný text záznamu

Synthesis and Evaluation of Novel Pyrimido-Acridone, -Phenoxadine, and -Carbazole as Topoisomerase II Inhibitors

Autor: Kentaro Yoshimatsu, Katsuji Nakamura, Takeshi Nagasu, Hiroyuki Sugumi, Jun Niijima, Toshimi Okada, Toshimitsu Uenaka, Nozomu Koyanagi, Kappei Tsukahara, Atsumi Yamaguchi, Hiroshi Yoshino, Kyosuke Kitoh, Junichi Kamata, Yoshihiko Kotake

Publikováno v: Chemical and Pharmaceutical Bulletin. 52:1071-1081

As part of a series of studies to discover new topoisomerase II inhibitors, novel pyrimidoacridones, pyrimidophenoxadines, and pyrimidocarbazoles were synthesized, and in vitro and in vivo antitumor activities and DNA-protein and/or DNA-topoisomerase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7dc5f0c0baabab56e3b6f243222fc67
https://doi.org/10.1248/cpb.52.1071

Zobrazit plný text záznamu

Selective determination of potential impurities in an active pharmaceutical ingredient using HPLC-SPE-HPLC

Autor: Jun Niijima, Eiichi Yamamoto, Naoki Asakawa

Publikováno v: Journal of pharmaceutical and biomedical analysis. 84

The present paper describes the selective determination of two synthetic intermediates (2,4-dichloro-6,7-dimethoxyquinazoline (IMP-1) and its derivative (IMP-2) as potential impurities in the active pharmaceutical ingredient (API)-A using two-dimensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe5e19fd426ab1bca346e8c785d46b7
https://pubmed.ncbi.nlm.nih.gov/23806999

Zobrazit plný text záznamu

A novel carbazole topoisomerase II poison, ER-37328: potent tumoricidal activity against human solid tumors in vitro and in vivo

Autor: Toshimitsu Uenaka, Hiroshi Yoshino, Tomoyoshi Taniguchi, Takeshi Nagasu, Katsuji Nakamura, Yoshihiko Kotake, Nozomu Koyanagi, Hiroyuki Sugumi, Jun Niijima, Toshimi Okada, Kentaro Yoshimatsu, Atsumi Yamaguchi, Kyosuke Kitoh, Junichi Kamata

Publikováno v: Cancer science. 94(1)

We have discovered a novel topoisomerase II (topo II) poison, ER-37328 (12,13-dihydro-5-[2-(dimethylamino)ethyl]-4H-benzo[c]pyrimido[5,6,1-jk]carbazole-4,6,10(5H,11H)-trione hydrochloride), which shows potent tumor regression activity against Colon 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93373ed80d2a520906c27a06783053c3
https://pubmed.ncbi.nlm.nih.gov/12708485

Zobrazit plný text záznamu

Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor

Autor: Katsuji, Nakamura, Hiroyuki, Sugumi, Atsumi, Yamaguchi, Toshimitsu, Uenaka, Yoshihiko, Kotake, Toshimi, Okada, Junichi, Kamata, Jun, Niijima, Takeshi, Nagasu, Nozomu, Koyanagi, Hiroshi, Yoshino, Kyosuke, Kitoh, Kentaro, Yoshimatsu

Publikováno v: Molecular cancer therapeutics. 1(3)

DNA topoisomerase II has been shown to be an important therapeutic target in cancer chemotherapy. Here, we describe studies on the antitumor activity of a novel topoisomerase II inhibitor, ER-37328 [12,13-dihydro-5-[2-(dimethylamino)ethyl]-4H-benzo[c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c50add1f41eaf7458e971ba720077bf
https://pubmed.ncbi.nlm.nih.gov/12467211

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání