Výsledky vyhledávání

The PI3K/mTOR dual inhibitor NVP-BEZ235 reduces the growth of ovarian clear cell carcinoma

Autor: Michiko Nonaka, Tasuku Harada, Tetsuro Oishi, Nao Oumi, Jun Naniwa, Akiko Kudoh, Mayumi Nishimura, Seiya Sato, Hiroaki Itamochi, Junzo Kigawa, Misaki Kato, Shinya Sato, Muneaki Shimada

Publikováno v: Oncology Reports. 32:553-558

Patients with clear cell carcinoma of the ovary (OCCC) have poor survival due to resistance to standard chemotherapy. OCCC has frequent activating mutations of the PIK3CA gene. The present study was conducted to clarify the efficacy of the inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4431a88250cd259d791adf01aa8f82
https://doi.org/10.3892/or.2014.3268

Zobrazit plný text záznamu

Activation of the Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Pathway Overcomes Cisplatin Resistance in Ovarian Carcinoma Cells

Autor: Wakae Kawaguchi, Hiroaki Itamochi, Jun Naniwa, Tetsuro Oishi, Junzo Kigawa, Akiko Kudoh, Michiko Nonaka, Seiya Sato, Kazunori Uegaki, Naoki Terakawa, Shinya Sato, Muneaki Shimada, Tasuku Harada

Publikováno v: International Journal of Gynecologic Cancer. 22:922-929

ObjectiveThis study was aimed to elucidate the roles of the mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3′-kinase (PI3K)/Akt pathways in regulating cytotoxicity induced by cispl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e29dcae4ddbc6dfdd99405b66a13097
https://doi.org/10.1097/igc.0b013e31824f0b13

Zobrazit plný text záznamu

Combination chemotherapy of oxaliplatin and 5-fluorouracil may be an effective regimen for mucinous adenocarcinoma of the ovary: A potential treatment strategy

Autor: Tetsuro Oishi, Michiko Nonaka, Kazunori Uegaki, Junzo Kigawa, Hiroaki Itamochi, Jun Naniwa, Naoki Terakawa, Muneaki Shimada, Shinya Sato, Seiya Sato

Publikováno v: Cancer Science. 100:546-551

Resistance of ovarian mucinous adenocarcinoma to standard chemotherapy with paclitaxel and carboplatin is associated with poor prognosis, and an effective treatment is needed. The present study aimed to identify an effective chemotherapy for ovarian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8d45d0cfcc0952fe38390afa7229e1
https://doi.org/10.1111/j.1349-7006.2008.01065.x

Zobrazit plný text záznamu

Genetic diagnosis for chemosensitivity with drug-resistance genes in epithelial ovarian cancer

Autor: Wakae Kawaguchi, S Sato, Junzo Kigawa, Naoki Terakawa, Ruri Shimogai, Yasunobu Kanamori, Hiroaki Itamochi, Muneaki Shimada, Tetsuro Oishi, Jun Naniwa

Publikováno v: International Journal of Gynecologic Cancer. 17:76-82

We conducted the present study to investigate whether and how chemosensitivity can be determined by means of genetic diagnosis using drug-resistance genes in patients with epithelial ovarian cancer. A total of 75 patients who had epithelial ovarian c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8865880fd997b72a5b278bdae8e78bf6
https://doi.org/10.1111/j.1525-1438.2006.00752.x

Zobrazit plný text záznamu

PTEN is involved in the signal transduction pathway of contact inhibition in endometrial cells

Autor: Muneaki Shimada, Wakae Kawaguchi, Hiroaki Itamochi, Kazunori Uegaki, Tetsuro Oishi, Yasunobu Kanamori, Masakuni Takahashi, Naoki Terakawa, Junzo Kigawa, Ruri Kaneko, Jun Naniwa

Publikováno v: Cell and Tissue Research. 323:523-528

PTEN is involved in the regulation of normal cellular functions in addition to its well-known role as a tumor suppressor. In the present study, we have shown that stable transfection of the PTEN gene into PTEN-mutated endometrial carcinoma cells lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2c461506705b5a775c1dbc35c852e0
https://doi.org/10.1007/s00441-005-0082-3

Zobrazit plný text záznamu

Leptomycin B enhances CDDP-sensitivity via nuclear accumulation of p53 protein in HPV-positive cells

Autor: Tetsuro Oishi, Naoki Terakawa, Takahiro Iba, Jun Naniwa, Yasunobu Kanamori, Ryoji Akeshima, Hiroaki Itamochi, Junzo Kigawa

Publikováno v: Cancer Science. 94:1099-1103

Cervical cancer, which commonly contains a wild-type p53 gene, is highly correlated with human papilloma virus (HPV) infection. Because the oncoprotein E6, derived from HPV, inhibits the function of p53 protein, the inhibition of apoptosis via the p5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f643fe3cd55d182515332cecd987ae
https://doi.org/10.1111/j.1349-7006.2003.tb01406.x

Zobrazit plný text záznamu

Dual inhibition of phosphatidylinositol 3'-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach for mucinous adenocarcinoma of the ovary

Autor: Jun Naniwa, Junzo Kigawa, Tasuku Harada, Akiko Kudoh, Tetsuro Oishi, Muneaki Shimada, Seiya Sato, Hiroaki Itamochi, Shinya Sato

Publikováno v: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 24(3)

Ovarian mucinous adenocarcinoma (MAC) resists standard chemotherapy and is associated with poor prognosis. A more effective treatment is needed urgently. The present study assessed the possibility of molecular-targeted therapy with a novel dual inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21dfdd355db26924645b568b78b69271
https://pubmed.ncbi.nlm.nih.gov/24552895

Zobrazit plný text záznamu

Checkpoint kinase inhibitor AZD7762 overcomes cisplatin resistance in clear cell carcinoma of the ovary

Autor: Jun Naniwa, Tasuku Harada, Nao Oumi, Seiya Sato, Tetsuro Oishi, Junzo Kigawa, Shinya Sato, Akiko Kudoh, Misaki Kato, Hiroaki Itamochi, Mayumi Nishimura, Muneaki Shimada

Publikováno v: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 24(1)

ObjectiveCheckpoint kinase (Chk) inhibitors are thought to increase the cytotoxic effects of DNA-damaging agents and are undergoing clinical trials. The present study was aimed to assess the potential to use the Chk1 and Chk2 inhibitor, AZD7762, with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b3c2a2e6c8c00193617461954b02cd
https://pubmed.ncbi.nlm.nih.gov/24362713

Zobrazit plný text záznamu

Outcome of stage IB2-IIB patients with bulky uterine cervical cancer who underwent neoadjuvant chemotherapy followed by radical hysterectomy

Autor: Imari Deura, Junzo Kigawa, Tetsuro Oishi, Tasuku Harada, Kazunori Uegaki, Seiya Sato, Hiroaki Itamochi, Muneaki Shimada, Jun Naniwa, Shinya Sato

Publikováno v: International journal of clinical oncology. 19(2)

We performed a retrospective study to clarify the outcome of stage IB2–IIB patients with bulky cervical cancer who underwent neoadjuvant chemotherapy (NAC) followed by radical hysterectomy and adjuvant treatment. Sixty-five patients with bulky stag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76eb911afd446d60ddfa3b363ebdbc6a
https://pubmed.ncbi.nlm.nih.gov/23592280

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání