Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Jun MIMURO"'
Publikováno v:
Case Reports in Neurological Medicine, Vol 2015 (2015)
An 80-year-old man was admitted for acute subdural hematoma caused by a mild brain injury. His coagulation test showed an isolated prolongation of activated partial thromboplastin time (aPTT). Though the subdural hematoma did not progress, oozing ble
Externí odkaz:
https://doaj.org/article/7a3b481290f141e988c0be9c51d5d2a7
Autor:
Yuji Kashiwakura, Jun Mimuro, Akira Onishi, Masaki Iwamoto, Seiji Madoiwa, Daiichiro Fuchimoto, Shunichi Suzuki, Misae Suzuki, Shoichiro Sembon, Akira Ishiwata, Atsushi Yasumoto, Asuka Sakata, Tsukasa Ohmori, Michiko Hashimoto, Satoko Yazaki, Yoichi Sakata
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49450 (2012)
Hemophilia A is a common X chromosome-linked genetic bleeding disorder caused by abnormalities in the coagulation factor VIII gene (F8). Hemophilia A patients suffer from a bleeding diathesis, such as life-threatening bleeding in the brain and harmfu
Externí odkaz:
https://doaj.org/article/4cfecf2032ce497181437dd38780f7ed
Autor:
Keiya Ozawa, Yuji Kashiwakura, Jun Mimuro, Yoichi Sakata, Tsukasa Ohmori, M. Inoue, Seiji Madoiwa, Mamoru Hasegawa
Publikováno v:
Haemophilia. 20:e40-e44
Summary The use of induced pluripotent stem cells (iPSCs) as an autologous cell source has shed new light on cell replacement therapy with respect to the treatment of numerous hereditary disorders. We focused on the use of iPSCs for cell-based therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a152929e5e8acae4899346ce5d0956
https://doi.org/10.1111/hae.12311
https://doi.org/10.1111/hae.12311
Autor:
Jun Mimuro, Masashi Taki, Michio Sakai, Midori Shima, Shinji Muto, Hiroaki Mizukami, Tsukasa Ohmori, Yoichi Sakata, Tadashi Matsushita, Satoshi Higasa, Keiya Ozawa, Seiji Madoiwa
Publikováno v:
Journal of Medical Virology. 86:1990-1997
Pre-existing antibodies against adeno-associated virus (AAV), caused by natural AAV infections, interfere with recombinant AAV vector-mediated gene transfer. We studied the prevalence of neutralizing antibodies against AAV serotypes 1, 2, 5, 8, and 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b06f9cf0cc47d56d18c05183b23999eb
https://doi.org/10.1002/jmv.23818
https://doi.org/10.1002/jmv.23818
Autor:
Tadashi Matsushita, Yoichi Sakata, Hoyu Takahashi, Tatsuhiko Kuroda, Isao Kitajima, Yutaka Eguchi, Jun Mimuro, Hajime Tsuji
Publikováno v:
Thrombosis Research. 131:436-443
article i nfo Introduction: We assessed the safety and effectiveness of recombinant soluble thrombomodulin (thrombomodulin alfa, TM-α) in the treatment of disseminated intravascular coagulation (DIC) in a post-marketing surveillance. Methods: The ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1e8657c095a12159b4b7fb1dc94aa7
https://doi.org/10.1016/j.thromres.2013.03.008
https://doi.org/10.1016/j.thromres.2013.03.008
Autor:
Yoichi Sakata, Tsukasa Ohmori, Tomokazu Ikemoto, Shuji Hishikawa, Asuka Sakata, Jun Mimuro, Keiya Ozawa, Hiroaki Mizukami, Akira Ishiwata, Seiji Madoiwa, Fumiko Ono
Publikováno v:
Molecular Therapy. 21:318-323
Neutralizing antibodies (NAbs) against adeno-associated viruses (AAVs) are known to interfere with AAV vector-mediated gene transfer by intravascular delivery. Evading the inhibitory effects of antibodies against AAV vectors is necessary for efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a15987ef91409728acdc99c10d4091
https://doi.org/10.1038/mt.2012.258
https://doi.org/10.1038/mt.2012.258
Publikováno v:
Gene Therapy and Cell Therapy Through the Liver ISBN: 9784431556657
Adeno-associated virus (AAV) vector is widely used in gene transfer purposes. Not only the experimental gene transfer but also applications toward disease therapy are promising. Numerous attempts are ongoing for this purpose. One of the most prominen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eac0cd61efbf0cdc7c186209362b7116
https://doi.org/10.1007/978-4-431-55666-4_6
https://doi.org/10.1007/978-4-431-55666-4_6
Autor:
Shigeo Ookawara, Keiichi Ichimura, Osamu Matsuo, Seiji Madoiwa, Tsukasa Ohmori, Masumi Ichikawa, Kazuo Katoh, Yoichi Sakata, Takeharu Kanazawa, Nobuko Makino, Jun Mimuro
Publikováno v:
International Forum of Allergy & Rhinology. 3:458-467
Background Tissue type plasminogen activator (tPA) functions as a fibrinolytic factor in the blood and has unique roles in the nervous system. However, the role of tPA in the olfactory epithelium (OE) is still unclear. Generally, surgical ablation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::334da6f2ffe35a8accda998efe9f43e0
https://doi.org/10.1002/alr.21124
https://doi.org/10.1002/alr.21124
Autor:
Shigeo Ookawara, Nobuko Makino, Takeharu Kanazawa, Toshio Ishikawa, Masumi Ichikawa, Jun Mimuro, Osamu Matsuo, Yoichi Sakata, Keiichi Ichimura, Yasushi Ohta, Kazuo Katoh, Seiji Madoiwa, Shu Takigami
Publikováno v:
The Journal of Laryngology & Otology. 126:1114-1120
Objective:This study aimed to investigate the function of tissue plasminogen activator in the olfactory epithelium of mice following neural injury.Method:Transmission electron microscopy was used to study the changes in the morphology of the olfactor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5476c8dd44a526b31c01053e4f7c4a7b
https://doi.org/10.1017/s002221511200206x
https://doi.org/10.1017/s002221511200206x
Autor:
Atsushi Yasumoto, Asuka Sakata, Tsukasa Ohmori, Yoichi Sakata, Jun Mimuro, M. Inoue, Keiya Ozawa, Seiji Madoiwa, Yuji Kashiwakura, Mamoru Hasegawa, Akira Ishiwata
Publikováno v:
Journal of Thrombosis and Haemostasis. 10:1802-1813
Summary. Background: Transplantation of cells overexpressing a target protein represents a viable gene therapeutic approach for treating hemophilia. Here, we focused on the use of autologous mesenchymal stem cells (MSCs) expressing coagulation factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0154d8d063db7cba815f2de098cf3f7c
https://doi.org/10.1111/j.1538-7836.2012.04851.x
https://doi.org/10.1111/j.1538-7836.2012.04851.x