LOW DOSE-RATE RADIATION-SPECIFIC ALTERATIONS FOUND IN A GENOME-WIDE GENE EXPRESSION ANALYSIS OF THE MOUSE LIVER

Autor: Katsuyoshi Fujikawa, Takashi Sugihara, Satoshi Tanaka, Ignacia Tanaka, Shingo Nakamura, Masako Nakamura-Murano, Hayato Murano, Jun-ichiro Komura

Publikováno v: Radiation Protection Dosimetry. 198:1165-1169

Life span shortening and increased incidences of cancer and non-cancer diseases were observed in B6C3F1 mice irradiated with gamma-rays at a low dose-rate (LDR) of 20 mGy/d for 400 d. A genome-wide gene expression profiling of livers from mice irradi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad17112c9b588eafb3961914fbfd3fd9
https://doi.org/10.1093/rpd/ncac088

Life Span, Cause of Death and Neoplasia in B6C3F1 Mice Exposed In Utero to Low- and Medium-Dose-Rate Gamma Rays

Autor: Ignacia B. Tanaka, Rei Nakahira, Jun-ichiro Komura, Satoshi Tanaka

Publikováno v: Radiation research. 198(6)

Previously, we reported that while low-dose-rate (LDR) gamma-ray exposure to 20 mGy/day for the entire gestation period (gestation days 0-18) did not result in any significant effect in B6C3F1 pups up to 10 weeks of age when compared to the non-irrad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60e1cd559bc500dcf2f8f90818e1afb
https://pubmed.ncbi.nlm.nih.gov/36223164

Increased Frequency of Copy Number Variations Revealed by Array Comparative Genomic Hybridization in the Offspring of Male Mice Exposed to Low Dose-Rate Ionizing Radiation

Autor: Ignacia Braga Tanaka, Chihiro Harada, Yoshiko Ayabe, Jun-ichiro Komura, Keiji Ogura, Satoshi Tanaka

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 12437, p 12437 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 22

There is very little information on the transgenerational or genetic effects of low dose-rate ionizing radiation. We report the detection of the transgenerational effects of chronic low dose-rate irradiation in mice, at the molecular level in the who

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95398ad62cfd132130be74cf753a4442
https://www.mdpi.com/1422-0067/22/22/12437

Minimum environmental enrichment is effective in activating antitumor immunity to transplanted tumor cells in mice

Autor: Jun-ichiro Komura, Heita Miura, Satoshi Tanaka, Daisaku Takai, Akiko Abe

Publikováno v: Experimental Animals

Studies of environmental enrichment are progressing in the fields of nervous system, stress and exercise. Recently, housing in enriched environment have shown to influence to carcinogenesis and life span. However, the study for antitumor effect of en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64da1890e1d57a2844367b238438417d
http://europepmc.org/articles/PMC6842806

Effects of Continuous In Utero Low- and Medium-Dose-Rate Gamma-Ray Exposure on Fetal Germ Cells

Autor: Yoshiko Ayabe, Satoshi Tanaka, Jun-ichiro Komura, Ignacia Braga-Tanaka, Rei Nakahira

Publikováno v: Radiation research. 195(3)

The effects of radiation exposure on germ cells and the gonads have been well studied at acute high-dose exposures, but the effects of chronic low-dose-rate (LDR) irradiation, particularly relevant for radiation protection, on germ cells and the gona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adae8a4312df678f04d4df0d571ff58
https://pubmed.ncbi.nlm.nih.gov/33347599