Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jun Ichi Yata"'
Autor:
Tomohiro Morio, Hans D. Ochs, Jun Ichi Yata, Kiyoko Fukami, Kohsuke Imai, Hiroaki Miki, Tadaomi Takenawa, Alejandro Aruffo, Qili Zhu, Shigeaki Nonoyama
Publikováno v:
Clinical Immunology. 92:128-137
In this study, we investigated the role of the pleckstrin homology (PH) domain of the Wiskott-Aldrich syndrome protein (WASP) in the regulation of actin cytoskeleton, which is defective in patients with Wiskott-Aldrich syndrome (WAS) and X-linked thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205cf1eb7cdea4dbaef470ab53c6afd3
https://doi.org/10.1006/clim.1999.4746
https://doi.org/10.1006/clim.1999.4746
Autor:
Hans D. Ochs, Hano Toru, Shimon Pollack, David B. Lewis, Shigeaki Nonoyama, Amos Etzioni, Jun Ichi Yata, Dennis P. Ruggerie, Alejandro Aruffo
Publikováno v:
European Journal of Immunology. 28:589-598
Major histocompatibility complex (MHC) class II deficiency (bare lymphocyte syndrome, BLS) is a rare primary immunodeficiency classified as a subgroup of severe combined immunodeficiency. We studied T and B lymphocyte function by examining the CD40 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::680ebab333952baef13c80aef8ce4258
https://doi.org/10.1002/(sici)1521-4141(199802)28:02<589::aid-immu589>3.0.co
https://doi.org/10.1002/(sici)1521-4141(199802)28:02<589::aid-immu589>3.0.co
Autor:
Ryota Hosoya, Takeshi Nagao, Jun Komiyama, Mutsuro Ohira, Koichi Ishimoto, Takashi Kaneko, Koichi Nishihara, Koichiro Yamada, Toshiji Shitara, Jun-ichi Akatsuka, Hiroshi Ohtsuki, Jun-ichi Yata, Masao Yamamoto, Hiroshi Chihara, Kaneo Yamada, Koreatsu Ito, Hayashi M.D. Yasuhide, Tomohiro Saito, Yasutaka Hoshi, Ichiro Inana, Masafumi Kaneko, Kozo Nishimura, Shusuke Matsuyama, Takeyuki Sato, Emiko Wada, Akira Ishikawa, Ichiro Tsukimoto, Shun-ichi Kato, Yoji Ohkawa, Ken-ichi Sugita, Masahiro Tsuchida, Koichiro Ikuta, Shinpei Nakazawa, Nobuyuki Taguchi, Yukiko Tsunematsu, Atsushi Shibuya, Yuri Okimoto, Fumio Bessho, Toshiharu Furukawa, Katsumi Torigoe, Masashige Tsukada, Keiko Yamamoto
Publikováno v:
Pediatrics International. 33:522-532
The Tokyo Children's Cancer Study Group (TCCSG) has performed prospective randomized controlled studies since 1984 for childhood acute lymphoblastic leukemia (ALL). Four hundred and ninety-eight newly diagnosed patients were treated with 5 different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab3708c8d6319edc794feba6f7446bf0
https://doi.org/10.1111/j.1442-200x.1991.tb02581.x
https://doi.org/10.1111/j.1442-200x.1991.tb02581.x
Autor:
Tomohiro Morio, Takeshi Isoda, Daisuke Tomizawa, Kazuhiro Kogawa, Shuki Mizutani, Masayuki Nagasawa, Michiko Kajiwara, H Maeda, Yoichiro Tsuji, Sukeyuki Ito, Jun Ichi Yata, Yoshiyuki Minegishi, N Sasaki, Yuki Aoki, H Ohkawa, Kohsuke Imai, Masako Imai, Shigeaki Nonoyama
Publikováno v:
Bone marrow transplantation. 37(5)
We retrospectively analyzed our results of 30 patients with three distinctive primary immunodeficiency diseases (PIDs)--severe combined immunodeficiency (SCID, n = 11), Wiskott-Aldrich syndrome (WAS, n = 11) and X-linked hyper-immunoglobulin M (IgM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301881605d18a9295bfbab4595f375fa
https://pubmed.ncbi.nlm.nih.gov/16435016
https://pubmed.ncbi.nlm.nih.gov/16435016
Autor:
Shuji Takagi, Hiroji Okawa, Yoshiyuki Minegishi, Jun Ichi Yata, Naoto Ishii, Hirotoshi Maeda, Masahiro Tsuchida, Kazuo Sugamura
Publikováno v:
Human Genetics. 96:681-683
Three novel mutations in the IL-2R gamma chain gene were identified in four Japanese patients with X-linked severe combined immunodeficiency by direct sequence analysis of polymerase chain reaction (PCR) amplified DNA fragments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f79cdd2b74e28bdb4500c632709bf7b
https://doi.org/10.1007/bf00210299
https://doi.org/10.1007/bf00210299
Autor:
Tomohiro Morio, Yinzhu Jin, Hans D. Ochs, Shuki Mizutani, Sukeyuki Itoh, Shigeaki Nonoyama, Yi Zhu, Jun Ichi Yata, Michiko Kajiwara, Kohsuke Imai
Publikováno v:
Blood. 103(2)
Mutations of the Wiskott-Aldrich syndrome protein (WASP) gene result either in the classic Wiskott-Aldrich syndrome (WAS) or in a less severe form, X-linked thrombocytopenia (XLT). A phenotype-genotype correlation has been reported by some but not by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1433d0e07bad208450078abec97c4a
https://pubmed.ncbi.nlm.nih.gov/12969986
https://pubmed.ncbi.nlm.nih.gov/12969986
Autor:
Hirobumi Teraoka, Makoto Seki, Sang Kyou Lee, Silva H. Hanissian, Hiroyasu Nakano, Jun Kondo, Shigeaki Nonoyama, Raif S. Geha, Leonard B. Bacharier, Jun Ichi Yata, Tomohiro Morio
Publikováno v:
Immunity. 11(3)
CD40 plays a critical role in survival, growth, differentiation, and class switching of B lymphocytes. Although Ku is required for immunoglobulin class switching, how CD40 signal transduction is coupled to Ku is still unknown. Here, we show that CD40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91980bb8b876d66fad7d4a02959c667b
https://pubmed.ncbi.nlm.nih.gov/10514012
https://pubmed.ncbi.nlm.nih.gov/10514012
Autor:
Toshio Kunikata, Tomoki Yamadori, Shigeyuki Arai, Jun Ichi Yata, Tadamitsu Kishimoto, Masato Matsushita, Hans D. Ochs, Masashi Kurimoto, Shigeaki Nonoyama, Tomohiro Kurosaki, Yoshihiro Baba, Kohsuke Imai, Satoshi Tsukada, Shoji Hashimoto
Publikováno v:
Scopus-Elsevier
Bruton’s tyrosine kinase (Btk) has been shown to play a role in normal B-lymphocyte development. Defective expression of Btk leads to human and murine immunodeficiencies. However, the exact role of Btk in the cytoplasmic signal transduction in B ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505e89f5ad120c209ed0c6d33af2f43c
https://pubmed.ncbi.nlm.nih.gov/10068673
https://pubmed.ncbi.nlm.nih.gov/10068673
Autor:
Hiroyuki Nunoi, Kuniaki Seyama, Mitsunobu Shimadzu, Michael G. Neubauer, H. D. Och, Shigeaki Nonoyama, Hano Toru, Jun Ichi Yata
Publikováno v:
Human genetics. 99(5)
X-linked hyper-IgM syndrome (XHIM) is a rare primary immunodeficiency caused by a defective CD40 ligand. We identified mutations of the CD40 ligand gene in 13 unrelated Japanese XHIM patients. Of the four patients with missense mutations, one had a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb013a21a3343e7f9c28a02e2b28f1c1
https://pubmed.ncbi.nlm.nih.gov/9150729
https://pubmed.ncbi.nlm.nih.gov/9150729
Autor:
Tomohiro Morio, Tadashi Matsumoto, Tsuji Y, Tatsuro Kondoh, Jun Ichi Yata, K. Hayashi, Masaaki Yoshimoto
Publikováno v:
American journal of medical genetics. 60(5)
We report two sisters in a family representing manifestations of Wiskott-Aldrich syndrome (WAS), an X-linked immunodeficiency disorder. An elder sister had suffered from recurrent infections, small thrombocytopenic petechiae, purpura, and eczema for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57b988bc5ee22ac779ce3e9847ce604
https://pubmed.ncbi.nlm.nih.gov/9129730
https://pubmed.ncbi.nlm.nih.gov/9129730