Zobrazeno 1 - 10
of 283
pro vyhledávání: '"Jun Ichi Satoh"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Genetic variations of TREM2 have been implicated as a risk factor of Alzheimer’s disease (AD). Recent studies suggest that the loss of TREM2 function compromises microglial responses to the accumulation of amyloid beta. Previously, we foun
Externí odkaz:
https://doaj.org/article/358f47f6e67642fe874d96b912eee2ff
Autor:
Fabia Filipello, Shih-Feng You, Farzaneh S. Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A. Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A. Minaya, Arun Renganathan, Anil G. Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K. Iyer, Marina Cella, Wendy H. Raskind, Laura Piccio, Celeste M. Karch
Publikováno v:
Acta Neuropathologica. 145:749-772
TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic variation in the TREM2 gene has been implicated in risk for Alzheimer’s disease and frontotemporal dementia, while homozygous TREM2 mutations cause a rare leukody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1808ffc92b74dc4bbdd42e0fae1c83a4
https://doi.org/10.1007/s00401-023-02568-y
https://doi.org/10.1007/s00401-023-02568-y
Autor:
Olena Korvatska, Kostantin Kiianitsa, Alexander Ratushny, Mark Matsushita, Neal Beeman, Wei-Ming Chien, Jun-Ichi Satoh, Michael O. Dorschner, C. Dirk Keene, Theo K. Bammler, Thomas D. Bird, Wendy H. Raskind
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The R47H variant in the microglial triggering receptor expressed on myeloid cell 2 (TREM2) receptor is a strong risk factor for Alzheimer’s disease (AD). To characterize processes affected by R47H, we performed an integrative network analysis of ge
Externí odkaz:
https://doaj.org/article/473307c7b17f4f2c97dff1c8062620f1
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Loss-of-function mutations in TREM2 cause Nasu-Hakola disease (NHD), a rare genetic disease characterized by early-onset dementia with leukoencephalopathy and bone cysts. An NHD-associated mutation, c.482 + 2 T > C, disrupts the splice donor
Externí odkaz:
https://doaj.org/article/c62d64c8e1ef42d6b0c92f5a3a770ed6
Autor:
Sayuri Higaki, Masashi Muramatsu, Akio Matsuda, Kenji Matsumoto, Jun-Ichi Satoh, Makoto Michikawa, Shumpei Niida
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196929 (2018)
MiRNA molecules are important post-transcriptional regulators of gene expression in the brain function. Altered miRNA profiles could represent a defensive response against the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease (
Externí odkaz:
https://doaj.org/article/a5e6c54ed8e24012a063082168d97b04
Bioinformatics Data Mining Approach Suggests Coexpression of AGTPBP1 with an ALS-linked Gene C9orf72
Autor:
Shouta Kitano, Yoshihiro Kino, Yoji Yamamoto, Mika Takitani, Junko Miyoshi, Tsuyoshi Ishida, Yuko Saito, Kunimasa Arima, Jun-ichi Satoh
Publikováno v:
Journal of Central Nervous System Disease, Vol 2015, Iss 7, Pp 15-26 (2015)
Externí odkaz:
https://doaj.org/article/556616291edc4cf897c6d17259f31445
Publikováno v:
Journal of Central Nervous System Disease, Vol 2015, Iss 7, Pp 1-14 (2015)
Externí odkaz:
https://doaj.org/article/a829e76b1820481a99a6d58feaa8a3a4
Publikováno v:
Biomarker Insights, Vol 2015, Iss 10, Pp 21-31 (2015)
Externí odkaz:
https://doaj.org/article/b0bdc03930004032a4d612dfacbeef7c
Autor:
Hitoshi Kamauchi, Satoshi Hayashi, Toshikatsu Takanami, Hiroaki Sasaki, Koji Fujihara, Yoshihiro Kino, Kiyotaka Koyama, Masahiro Noji, Kaoru Kinoshita, Jun-ichi Satoh, Youki Masuda
Publikováno v:
Journal of Natural Products. 84:1748-1754
To develop drugs to treat Alzheimer's disease (AD) on the basis of the amyloid cascade hypothesis, the amyloid-β (Aβ) aggregation inhibitory activities of 110 extracts from mushrooms were evaluated by thioflavin T (Th-T) assays. The MeOH extract of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5adec94a793b00f2b3e3ad10dfe2b4f2
https://doi.org/10.1021/acs.jnatprod.0c01329
https://doi.org/10.1021/acs.jnatprod.0c01329
Publikováno v:
Journal of Central Nervous System Disease, Vol 2014, Iss 6, Pp 69-78 (2014)
Externí odkaz:
https://doaj.org/article/3c9589b5c8c6430bb886f33feeaf74c8