Zobrazeno 1 - 10
of 828
pro vyhledávání: '"Jun Ichi Kira"'
Autor:
Ezgi Ozdemir Takase, Ryo Yamasaki, Satoshi Nagata, Mitsuru Watanabe, Katsuhisa Masaki, Hiroo Yamaguchi, Jun-ichi Kira, Hideyuki Takeuchi, Noriko Isobe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract In chronic stages of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalitis (EAE), connexin (Cx)43 gap junction channel proteins are overexpressed because of astrogliosis. To elucidate the role of increased Cx43,
Externí odkaz:
https://doaj.org/article/677e0f459eba49d6aa9029b65a57d82b
Autor:
Tomoko Narita, Shunya Nakane, Akiko Nagaishi, Naoya Minami, Masaaki Niino, Naoki Kawaguchi, Hiroyuki Murai, Jun-ichi Kira, Jun Shimizu, Kazuo Iwasa, Hiroaki Yoshikawa, Yuki Hatanaka, Masahiro Sonoo, Yuko Shimizu, Hidenori Matsuo
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 16 (2023)
Background: Treatment for ocular myasthenia gravis (OMG) has not yet been well established. Few reports have been published on the clinical practice and outcomes of OMG. Objectives: We investigated treatment of OMG and its outcomes in Japan. Design:
Externí odkaz:
https://doaj.org/article/4502b9f6815f4854ba27c57f2bfaf18c
Autor:
Shoji Matsumoto, Ichiro Nakahara, Ayuko Yasuda, Akira Ishii, Michiya Kubo, Kentaro Yamada, Masakazu Okawa, Hidehisa Nishi, Toshiyasu Miura, Daisuke Koike, Shinpei Okita, Michiru Aoki, Koji Tanaka, Yoshio Suyama, Jun Morioka, Akiko Hasebe, Jun Tanabe, Kenichiro Suyama, Sadayoshi Watanabe, Kiyonori Kuwahara, Takuma Ishihara, Hiroshi Koyama, Jun‐ichi Kira
Publikováno v:
Stroke: Vascular and Interventional Neurology, Vol 3, Iss 2 (2023)
Background Reperfusion therapy for acute ischemic stroke efficacy is highly time dependent; therefore, stroke centers are required to further reduce the delays from hospital arrival to treatment efficiently. We developed a visual task management appl
Externí odkaz:
https://doaj.org/article/12cb0386c00c4235b10e92b4ca960089
Autor:
Satoshi Nagata, Ryo Yamasaki, Ezgi Ozdemir Takase, Kotaro Iida, Mitsuru Watanabe, Katsuhisa Masaki, Marion Heleen Cathérine Wijering, Hiroo Yamaguchi, Jun-ichi Kira, Noriko Isobe
Publikováno v:
Biology, Vol 12, Iss 9, p 1217 (2023)
We previously reported a novel secondary progressive multiple sclerosis (SPMS) model, progressive experimental autoimmune encephalomyelitis (pEAE), in oligodendroglia-specific Cx47-inducible conditional knockout (Cx47 icKO) mice. Based on our prior s
Externí odkaz:
https://doaj.org/article/90bddc8b7a7146269bca5792f1f689bb
Autor:
Wataru Shiraishi, Ryo Yamasaki, Yu Hashimoto, Senri Ko, Yuko Kobayakawa, Noriko Isobe, Takuya Matsushita, Jun-ichi Kira
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Macrophages expressing C–C chemokine receptor type 2 (CCR2) infiltrate the central and peripheral neural tissues of amyotrophic lateral sclerosis (ALS) patients. To identify the functional role of CCR2+ macrophages in the pathomechanisms o
Externí odkaz:
https://doaj.org/article/38e6c8f790e142f19d800032a48c1af0
Autor:
Hayato Une, Ryo Yamasaki, Satoshi Nagata, Hiroo Yamaguchi, Yuko Nakamuta, Ulfa Camelia Indiasari, Yiwen Cui, Koji Shinoda, Katsuhisa Masaki, Magdalena Götz, Jun-ichi Kira
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
Abstract Background Brain astroglia are activated preceding the onset of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). We characterized the effects of brain astroglia on spinal cord inflammation, focusin
Externí odkaz:
https://doaj.org/article/37938b5b62a04f64beb4ea1d43370c05
Autor:
Mitsuru Watanabe, Yuri Nakamura, Shinya Sato, Masaaki Niino, Hikoaki Fukaura, Masami Tanaka, Hirofumi Ochi, Takashi Kanda, Yukio Takeshita, Takanori Yokota, Yoichiro Nishida, Makoto Matsui, Shigemi Nagayama, Susumu Kusunoki, Katsuichi Miyamoto, Masanori Mizuno, Izumi Kawachi, Etsuji Saji, Takashi Ohashi, Shun Shimohama, Shin Hisahara, Kazutoshi Nishiyama, Takahiro Iizuka, Yuji Nakatsuji, Tatsusada Okuno, Kazuhide Ochi, Akio Suzumura, Ken Yamamoto, Yuji Kawano, Shoji Tsuji, Makoto Hirata, Ryuichi Sakate, Tomonori Kimura, Yuko Shimizu, Akiko Nagaishi, Kazumasa Okada, Fumie Hayashi, Ayako Sakoda, Katsuhisa Masaki, Koji Shinoda, Noriko Isobe, Takuya Matsushita, Jun-ichi Kira
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract HLA genotype-clinical phenotype correlations are not established for multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). We studied HLA-DRB1/DPB1 genotype–phenotype correlations in 528 MS and 165 NMOSD cases using
Externí odkaz:
https://doaj.org/article/67db0d0897834f4e92a7985435c2ebfc
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
BackgroundAlzheimer’s disease (AD) is the most common condition of all neurodegenerative diseases and is characterized by various cognitive dysfunctions. Recent resting-state functional magnetic resonance imaging (rs-fMRI) studies have revealed the
Externí odkaz:
https://doaj.org/article/c29dedbbb7e14416ba5d65b890bde34c
Autor:
Hidenori Ogata, Xu Zhang, Saeko Inamizu, Ken‐ichiro Yamashita, Ryo Yamasaki, Takuya Matsushita, Noriko Isobe, Akio Hiwatashi, Shozo Tobimatsu, Jun‐ichi Kira
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 11, Pp 2297-2309 (2020)
Abstract Objective To characterize the frequency and patterns of optic, trigeminal, and facial nerve involvement by neuroimaging and electrophysiology in IgG4 anti‐neurofascin 155 antibody‐positive (NF155+) chronic inflammatory demyelinating poly
Externí odkaz:
https://doaj.org/article/b8e0eecc967b4aef864dcd47de55a189
Autor:
Takuya Matsushita, Katsuhisa Masaki, Noriko Isobe, Shinya Sato, Ken Yamamoto, Yuri Nakamura, Mitsuru Watanabe, Toshihiko Suenaga, Jun‐ichi Kira, the Japan Multiple Sclerosis Genetic Consortium
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 11, Pp 2082-2093 (2020)
Abstract Objective To identify genetic factors associated with susceptibility to and clinical features of neuromyelitis optica spectrum disorders (NMOSD). Methods Genome‐wide single nucleotide polymorphism (SNP) genotyping was conducted in 211 Japa
Externí odkaz:
https://doaj.org/article/e3a40113f55b4a8e8e11e45e8dd028f0