Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jun Ichi Kasuga"'
Autor:
Makoto Makishima, Hiromi Nobusada, Izumi Nakagome, Shuichi Hirono, Yuichi Hashimoto, Kenji Matsuno, Jun Ichi Kasuga, Hiroyuki Miyachi, Masao Ohashi
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:6375-6383
We previously demonstrated that the α-benzylphenylpropanoic acid-type PPARγ-selective agonist 6 exhibited a reversed stereochemistry-activity relationship, that is, the (R)-enantiomer is a more potent PPARγ agonist than the (S)-enantiomer, compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c479a91b47d1ac8aadcda808bea0358f
https://doi.org/10.1016/j.bmc.2012.08.061
https://doi.org/10.1016/j.bmc.2012.08.061
Autor:
Kenji Toyota, Hiroyuki Miyachi, Naoko Nagasawa, Takuji Oyama, Yuko Hirakawa, Yuichi Hashimoto, Kosuke Morikawa, Jun Ichi Kasuga, Tsuyoshi Waku
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
The structures of the ligand-binding domains (LBDs) of human peroxisome proliferator-activated receptors (PPARα, PPARγ and PPARδ) in complexes with a pan agonist, an α/δ dual agonist and a PPARδ-specific agonist were determined. The results exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa17b125db05c95ba416f6624475927b
http://europepmc.org/articles/PMC2714719
http://europepmc.org/articles/PMC2714719
Autor:
Shuichi Hirono, Makoto Makishima, Atsushi Aoyama, Hiroyuki Miyachi, Takuji Oyama, Yuichi Hashimoto, Kosuke Morikawa, Jun Ichi Kasuga, Kumiko Sako, Izumi Nakagome
Publikováno v:
YAKUGAKU ZASSHI. 129:709-718
A series of 3-(4-alkoxypheny)propanoic acid derivatives was prepared as candidate peroxisome proliferator-activated receptor (PPAR) delta-selective agonists, based on our previously discovered potent human PPARalpha/delta dual agonist TIPP-401 as a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f777df9da9017165c5d2918040f00c8a
https://doi.org/10.1248/yakushi.129.709
https://doi.org/10.1248/yakushi.129.709
Autor:
Jun Ichi Kasuga, Shuichi Hirono, Kosuke Morikawa, Hiroyuki Miyachi, Takuji Oyama, Makoto Makishima, Yuichi Hashimoto, Izumi Nakagome
Publikováno v:
ChemMedChem. 3:1662-1666
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceeaf58b5745e88cbb487804728caee2
https://doi.org/10.1002/cmdc.200800193
https://doi.org/10.1002/cmdc.200800193
Autor:
Yuko Hirakawa, Hiroyuki Miyachi, Kosuke Morikawa, Makoto Makishima, Takuji Oyama, Yuichi Hashimoto, Jun Ichi Kasuga
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4525-4528
We developed a potent peroxisome proliferator-activated receptor pan agonist (a candidate drug for treatment of altered metabolic homeostasis) by introducing fluorine atoms at appropriate position(s) of the known phenylpropionic acid-type pan agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c5d62e58c8cab4e02a482f551d6c90
https://doi.org/10.1016/j.bmcl.2008.07.046
https://doi.org/10.1016/j.bmcl.2008.07.046
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:771-774
Optically active ( S )-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared by using Evan’s chiral oxazolidinone technique and reductive amide N-alky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6af9ac1184b722592f55c6f1a5c1eb
https://doi.org/10.1016/j.bmcl.2005.11.029
https://doi.org/10.1016/j.bmcl.2005.11.029
Autor:
Kenji Ohgane, Shintaro Ban, Takuji Oyama, Hiroyuki Miyachi, Yuichi Hashimoto, Kosuke Morikawa, Yoshino Nishio, Jun Ichi Kasuga
Publikováno v:
Bioorganicmedicinal chemistry. 20(11)
Based on X-ray crystallographic analysis of a peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist complexed with human PPARs ligand binding domain (LBD), we previously reported the design and synthesis of a pyrene-based fluorescent P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71e372d03db3856f9385d8330d35c62
https://pubmed.ncbi.nlm.nih.gov/22551628
https://pubmed.ncbi.nlm.nih.gov/22551628
Autor:
Izumi Nakagome, Hiromu Kawasaki, Yuichi Hashimoto, Hiroyuki Miyachi, Shintaro Ban, Hiromi Nobusada, Jun Ichi Kasuga, Fusako Takayama, Shuichi Hirono
Publikováno v:
Bioorganicmedicinal chemistry. 19(10)
A series of α-ethylphenylpropanoic acid derivatives was prepared as candidate peroxisome proliferator-activated receptor (PPAR) α-selective agonists, based on our PPARα/δ dual agonist 3 as a lead compound. Structure-activity relationship studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572db14f7586f82ab37b91d753c02496
https://pubmed.ncbi.nlm.nih.gov/21530275
https://pubmed.ncbi.nlm.nih.gov/21530275
Autor:
Makoto Makishima, Yuichi Hashimoto, Hiroyuki Miyachi, Minoru Ishikawa, Jun Ichi Kasuga, Mitsuhiro Yonehara
Publikováno v:
Bioorganicmedicinal chemistry. 18(20)
To elucidate the molecular basis of peroxisome proliferator-activated receptor (PPAR) δ partial agonism, X-ray crystal structures of complexes of the PPARδ ligand-binding site with partial agonists are required. Unfortunately, reported PPARδ parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98856438bbfdf283582470c903dde37e
https://pubmed.ncbi.nlm.nih.gov/20843696
https://pubmed.ncbi.nlm.nih.gov/20843696
Autor:
Takuji Oyama, Hiroyuki Miyachi, Yuichi Hashimoto, Shuichi Hirono, Kumiko Sako, Izumi Nakagome, Atsushi Aoyama, Jun Ichi Kasuga, Makoto Makishima, Kosuke Morikawa
Publikováno v:
ChemInform. 40
A series of 3-(4-alkoxypheny)propanoic acid derivatives was prepared as candidate peroxisome proliferator-activated receptor (PPAR) delta-selective agonists, based on our previously discovered potent human PPARalpha/delta dual agonist TIPP-401 as a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dc1c6721206df911f4e8942e4531561
https://doi.org/10.1002/chin.200948235
https://doi.org/10.1002/chin.200948235