Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jun Ichi Asakawa"'
Autor:
Jun Sese, Yohei Minakuchi, Nori Nakamura, Jun-ichi Asakawa, Norio Shinkai, Tony Kuo, Mayumi Nishimura, Atsushi Toyoda, Arikuni Uchimura, Yasunari Satoh, Yoshiya Shimada, Harry M. Cullings
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
The exposure of germ cells to radiation introduces mutations in the genomes of offspring, and a previous whole-genome sequencing study indicated that the irradiation of mouse sperm induces insertions/deletions (indels) and multisite mutations (cluste
Publikováno v:
Radiation research. 187(6)
Ionizing radiation can induce mutations, and the majority of radiation-induced mutations in mammalian cells are deletions. The most critical types of radiation-induced DNA damage are DNA double-strand breaks, and these breaks are repaired by either t
Autor:
Satoh, Yasunari, Jun-Ichi, Asakawa, Nishimura, Mayumi, Kuo, Tony, Shinkai, Norio, M Cullings, Harry, Minakuchi, Yohei, Sese, Jun, Toyoda, Atsushi, Shimada, Yoshiya, Nakamura, Nori, Uchimura, Arikuni, Asakawa, Jun-ichi, Mayumi, Nishimura, Yoshiya, Shimada
Publikováno v:
Scientific Reports. 10(1):37
The exposure of germ cells to radiation introduces mutations in the genomes of offspring, and a previous whole-genome sequencing study indicated that the irradiation of mouse sperm induces insertions/deletions (indels) and multisite mutations (cluste
Publikováno v:
Radiation Research. 182:430-434
Estimates of genetic risks from radiation delivered to humans are derived largely from mouse studies. In males, the target is spermatogonia and a large amount of information is available. In contrast, in females, immature oocytes are the target, but
Autor:
Mieko Kodaira, Akiko Miura, Yoshiya Shimada, Nori Nakamura, Yoshiko Nakamoto, Harry M. Cullings, Masaaki Imanaka, Mayumi Nishimura, Jun-ichi Asakawa, Jun Kitamura, Takahiro Tsuji
Publikováno v:
Radiation research. 186(6)
Until the end of the 20th century, mouse germ cell data on induced mutation rates, which were collected using classical genetic methods at preselected specific loci, provided the principal basis for estimates of genetic risks from radiation in humans
Autor:
Ayse E. Erson, Rork Kuick, Martine Muleris, Jun Ichi Asakawa, Katharina Wimmer, Jean Marie Rouillard, Samir M. Hanash, Elizabeth M. Petty
Publikováno v:
Genome Research. 11:1453-1459
There is substantial interest in implementing technologies that allow comparisons of whole genomes of individuals and of tissues and cell populations. Restriction landmark genome scanning (RLGS) is a highly resolving gel-based technique in which seve
Autor:
Koichi Itoh, Jun-ichi Asakawa, Kunihiko Itoh, Mieko Kodaira, Naofumi Ishikawa, Shigenobu Nagataki
Publikováno v:
SEIBUTSU BUTSURI KAGAKU. 44:177-180
We have developed a novel two-dimensional display method of cDNA and compared the gene expression profile between human normal thyroid and papillary carcinoma. The cDNAs were synthesized with a Not I anchor primer from mRNAs prepared from surgery mat
Autor:
Jun-ichi Asakawa
Publikováno v:
SEIBUTSU BUTSURI KAGAKU. 42:145-154
Autor:
Jun-ichi Asakawa
Publikováno v:
SEIBUTSU BUTSURI KAGAKU. 41:307-312
We have developed a high resolution two-dimensional electrophoresis (2DE) of end labeled DNA fragments and have implemented a computer based approach for the analysis of the 2DE patterns. We have also undertaken studies of genetic variation which dis
Autor:
T. Glover, Barbara J. Lamb, Mieko Kodaira, John J. Fawcett, Samir M. Hanash, Jun Ichi Asakawa, Didier Thoraval, Scott Cram, Katharina Wimmer, Rork Kuick
Publikováno v:
Genomics. 38:124-132
The two-dimensional (2-D) separation of genomic digests has provided the means to analyze over 2000 unique restriction fragments simultaneously in a single gel, for genetic variation as well as for genomic alterations in cancer. By utilizing differen