Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jun Hoseki"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Endoplasmic reticulum (ER) maintains within, an oxidative redox state suitable for disulfide bond formation. We monitored the ER redox dynamics subsequent to proteasome inhibition using an ER redox probe ERroGFP S4. Proteasomal inhibition in
Externí odkaz:
https://doaj.org/article/df1b35d163c24cf2ac5874699cdd79ea
Autor:
Maho Yagi-Utsumi, Sumi Yoshikawa, Yoshiki Yamaguchi, Yohei Nishi, Eiji Kurimoto, Yoshihito Ishida, Takayuki Homma, Jun Hoseki, Yoshimi Nishikawa, Takaki Koide, Kazuhiro Nagata, Koichi Kato
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45930 (2012)
Heat shock protein 47 (Hsp47) acts as a client-specific chaperone for collagen and plays a vital role in collagen maturation and the consequent embryonic development. In addition, this protein can be a potential target for the treatment of fibrosis.
Externí odkaz:
https://doaj.org/article/5dae327d8d044f7b90243b47228b1f84
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
Endoplasmic reticulum (ER) maintains within, an oxidative redox state suitable for disulfide bond formation. We monitored the ER redox dynamics subsequent to proteasome inhibition using an ER redox probe ERroGFP S4. Proteasomal inhibition initially l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb89e92d3c255d6eb17572d4f23b7b58
https://doaj.org/article/df1b35d163c24cf2ac5874699cdd79ea
https://doaj.org/article/df1b35d163c24cf2ac5874699cdd79ea
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 80:726-734
Mitochondrial impairment and the resulting generation of reactive oxygen species (ROS) have been associated with aging and its related pathological conditions. Recently, dietary antioxidants have gained significant attention as potential preventive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5d4325382cf2795a5247e9d8ae9c14
https://doi.org/10.1080/09168451.2015.1123607
https://doi.org/10.1080/09168451.2015.1123607
Publikováno v:
Molecular Biology of the Cell
Glycosylated and nonglycosylated proteins misfolded in the ER are degraded by discrete but interchangeable pathways in the ERAD system. Disulfide reductase ERdj5 plays a central role in both pathways through the complex formation with EDEM and/or BiP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4334fa4563d408c9ed43a08c5240068c
https://doi.org/10.1091/mbc.e13-03-0138
https://doi.org/10.1091/mbc.e13-03-0138
Autor:
Jun, Hoseki
Publikováno v:
Seikagaku. The Journal of Japanese Biochemical Society. 88(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04f313850441ddd3f2ec3ee3ca6c5593
https://pubmed.ncbi.nlm.nih.gov/27192873
https://pubmed.ncbi.nlm.nih.gov/27192873
Publikováno v:
Bioscience Reports
We have created ERroGFP-S4, a novel ER redox probe suitable for monitoring redox dynamics in the oxidative environment of the ER. ERroGFP-S4 can be used for detection of aberrant ER redox states related to various physiological and pathological condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e0ba5f4b3e7cc7b220aecf149bd389
https://doi.org/10.1042/bsr20160027
https://doi.org/10.1042/bsr20160027
Autor:
Masatoshi Hagiwara, Jun Hoseki, Kazutaka Araki, Ryo Ushioda, Ken Ichi Maegawa, Yushi Matsumoto, Mamoru Suzuki, Kazuhiro Nagata, Kenji Inaba
Publikováno v:
Molecular Cell. 41(4):432-444
ER-associated degradation (ERAD) is an ER quality-control process that eliminates terminally misfolded proteins. ERdj5 was recently discovered to be a key ER-resident PDI family member protein that accelerates ERAD by reducing incorrect disulfide bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816fdc1d25eab720a153e9bac9e3a450
http://hdl.handle.net/2324/19148
http://hdl.handle.net/2324/19148
Autor:
Hiroko Ikushiro, Shigeru Fujii, Mohammad Mainul Islam, Jun Hoseki, Ikuko Miyahara, Akihiro Okamoto, Takeshi Murakawa, Hideyuki Hayashi
Publikováno v:
Journal of Biochemistry. 146:549-562
Serine palmitoyltransferase (SPT) is a key enzyme of sphingolipid biosynthesis and catalyses the pyridoxal 5'-phosphate (PLP)-dependent decarboxylative condensation reaction of l-serine with palmitoyl-CoA to generate 3-ketodihydrosphingosine. The cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fce6a40d6fe8c825f712cad4b1b61e6
https://doi.org/10.1093/jb/mvp100
https://doi.org/10.1093/jb/mvp100
Publikováno v:
Science. 321:569-572
Membrane and secretory proteins cotranslationally enter and are folded in the endoplasmic reticulum (ER). Misfolded or unassembled proteins are discarded by a process known as ER-associated degradation (ERAD), which involves their retrotranslocation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25b76923d95046f5101522baa21d75a
https://doi.org/10.1126/science.1159293
https://doi.org/10.1126/science.1159293