Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jun Hamazaki"'
Autor:
Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Sota Hashimoto, Hiroaki Iio, Masakazu Kato, Ai Kaiho-Soma, Yasushi Saeki, Jun Hamazaki, Shigeo Murata, Toshikazu Ushijima, Naoko Hattori, Fumiaki Ohtake
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Targeted protein degradation is a groundbreaking modality in drug discovery; however, the regulatory mechanisms are still not fully understood. Here, we identify cellular signaling pathways that modulate the targeted degradation of the antic
Externí odkaz:
https://doaj.org/article/4f25f96a86114608b7624ec4158746a7
Autor:
Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Hidetaka Kosako, Shoshiro Hirayama, Akinori Endo, Fumiaki Ohtake, Mako Kamiya, Yasuteru Urano, Yasushi Saeki, Jun Hamazaki, Shigeo Murata
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112880- (2023)
Summary: The proteasome plays a central role in intracellular protein degradation. Age-dependent decline in proteasome activity is associated with cellular senescence and organismal aging; however, the mechanism by which the proteasome plays a role i
Externí odkaz:
https://doaj.org/article/d0702f678d4a4409a78ed89b4d3a48d9
Autor:
Nobuo Kanazawa, Hiroaki Hemmi, Noriko Kinjo, Hidenori Ohnishi, Jun Hamazaki, Hiroyuki Mishima, Akira Kinoshita, Tsunehiro Mizushima, Satoru Hamada, Kazuya Hamada, Norio Kawamoto, Saori Kadowaki, Yoshitaka Honda, Kazushi Izawa, Ryuta Nishikomori, Miyuki Tsumura, Yusuke Yamashita, Shinobu Tamura, Takashi Orimo, Toshiya Ozasa, Takashi Kato, Izumi Sasaki, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Yutaka Inaba, Kayo Kunimoto, Satoshi Okada, Takeshi Taketani, Koichi Nakanishi, Shigeo Murata, Koh-ichiro Yoshiura, Tsuneyasu Kaisho
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Genetic variants of proteasome subunit genes have been shown to associate with perturbed immune function. Here authors show that a heterozygous missense variant of the immunoproteasome subunit β-type 9 causes an autoinflammatory/immune deficiency sy
Externí odkaz:
https://doaj.org/article/bc153bd94dab48289d8e89f5cfa52002
Autor:
Eiichi Hashimoto, Shota Okuno, Shoshiro Hirayama, Yoshiyuki Arata, Tsuyoshi Goto, Hidetaka Kosako, Jun Hamazaki, Shigeo Murata
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101299- (2020)
Summary: The proteasome is a therapeutic target in cancer, but resistance to proteasome inhibitors often develops owing to the induction of compensatory pathways. Through a genome-wide siRNA screen combined with RNA sequencing analysis, we identified
Externí odkaz:
https://doaj.org/article/e72ca096e2be491d880b45ad17bd0685
Autor:
Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Amy C. Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako, Yousuke Takahama
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2901-2916.e6 (2019)
Summary: The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Recent studies including single-cell transcriptomic analyses have highlighte
Externí odkaz:
https://doaj.org/article/3130a74898634135897cc8dbe1421653
Autor:
Rosie T. Jiang, Anna Yemelyanova, Deyin Xing, Ravi K. Anchoori, Jun Hamazaki, Shigeo Murata, Jeffrey D. Seidman, Tian-Li Wang, Richard B. S. Roden
Publikováno v:
Journal of Ovarian Research, Vol 10, Iss 1, Pp 1-12 (2017)
Abstract Background Ovarian carcinoma is highly dependent on the ubiquitin proteasome system (UPS), but its clinical response to treatment with the proteasome inhibitor bortezomib has been disappointing. This has driven exploration of alternate appro
Externí odkaz:
https://doaj.org/article/9ff98f8274cc4f019b69a84610a69d51
Autor:
Xiuxiu Lu, Urszula Nowicka, Vinidhra Sridharan, Fen Liu, Leah Randles, David Hymel, Marzena Dyba, Sergey G. Tarasov, Nadya I. Tarasova, Xue Zhi Zhao, Jun Hamazaki, Shigeo Murata, Terrence R. Burke, Jr., Kylie J. Walters
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
In the proteasome, Rpn2 provides the docking site for substrate receptor Rpn13. Here the authors present the structure of human Rpn13 Pru domain bound to its binding site in Rpn2 and provide insights into the mode of action for Rpn13-targeting molecu
Externí odkaz:
https://doaj.org/article/3558b297c27d4dde9ca8b170d554b63a
Autor:
Muhammad Myn Uddin, Izumi Ohigashi, Ryo Motosugi, Tomomi Nakayama, Mie Sakata, Jun Hamazaki, Yasumasa Nishito, Immanuel Rode, Keiji Tanaka, Tatsuya Takemoto, Shigeo Murata, Yousuke Takahama
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Foxn1 is involved in thymic epithelial cell (TEC) and CD8+T cell development. Here the authors show this development requires Foxn1 binding proximal to, and inducing transcription of, the gene encoding β5t in cortical TECs.
Externí odkaz:
https://doaj.org/article/da7be85cf2f6425ca21a3d52a9dcec58
Autor:
Jun Hamazaki, Shigeo Murata
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3683 (2020)
Protein folding is a substantively error prone process, especially when it occurs in the endoplasmic reticulum (ER). The highly exquisite machinery in the ER controls secretory protein folding, recognizes aberrant folding states, and retrotranslocate
Externí odkaz:
https://doaj.org/article/1770619134ee453789cebc7010a3621f
Autor:
Seung-Wook Shin, Natsumi Shimizu, Mikiko Tokoro, Satoshi Nishikawa, Yuki Hatanaka, Masayuki Anzai, Jun Hamazaki, Satoshi Kishigami, Kazuhiro Saeki, Yoshihiko Hosoi, Akira Iritani, Shigeo Murata, Kazuya Matsumoto
Publikováno v:
Biology Open, Vol 2, Iss 2, Pp 170-182 (2012)
Summary During the maternal-to-zygotic transition (MZT), maternal proteins in oocytes are degraded by the ubiquitin–proteasome system (UPS), and new proteins are synthesized from the zygotic genome. However, the specific mechanisms underlying the U
Externí odkaz:
https://doaj.org/article/a3b34855fdc1480fbb9cfc1200713357