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pro vyhledávání: '"Jun Cheng Du"'
Autor:
Jing Wu, Ren De Zhu, Guo Min Cao, Jun Cheng Du, Xin Liu, Liang Zhuo Diao, Zhao Yan Zhang, Yang Sheng Hu, Xin Hua Liu, Jing Bo Shi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 817-831 (2022)
T-LAK-cell-originated protein kinase (TOPK), a novel member of the mitogen-activated protein kinase family, is considered an effective therapeutic target for skin inflammation. In this study, a series (A − D) of paeonol derivatives was designed and
Externí odkaz:
https://doaj.org/article/8e6f3328a987410eab423607807111ee
Publikováno v:
Bioorganic chemistry. 120
On basis of Quercetin moiety, two series of 20 new compounds were designed and synthesized accordingly in this study, and their anti-inflammatory activities in vitro and in vivo were evaluated. At last, compound 8A2: 3- (1- (2- (4- (5-bromo-2-chlorob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4522deac35f9b3d1110f58b5b90f5fb5
https://pubmed.ncbi.nlm.nih.gov/35121555
https://pubmed.ncbi.nlm.nih.gov/35121555