Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Jun Aruga"'
Autor:
Yoshifumi Matsumoto, Hideki Miwa, Kei-ichi Katayama, Arata Watanabe, Kazuyuki Yamada, Takashi Ito, Shinsuke Nakagawa, Jun Aruga
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
The Slitrk family consists of six synaptic adhesion molecules, some of which are associated with neuropsychiatric disorders. In this study, we aimed to investigate the physiological role of Slitrk4 by analyzing Slitrk4 knockout (KO) mice. The Slitrk4
Externí odkaz:
https://doaj.org/article/a1e885e228654b458266ac9769705f8c
Autor:
Stephanie Efthymiou, Wenyan Han, Muhammad Ilyas, Jun Li, Yichao Yu, Marcello Scala, Nancy T. Malintan, Nikoleta Vavouraki, Kshitij Mankad, Reza Maroofian, Clarissa Rocca, Vincenzo Salpietro, Shenela Lakhani, Eric J. Mallack, Timothy Blake Palculict, Hong Li, Guojun Zhang, Faisal Zafar, Nuzhat Rana, Noriko Takashima, Hayato Matsunaga, Claudia Manzoni, Pasquale Striano, Mark F. Lythgoe, Jun Aruga, Wei Lu, Henry Houlden
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
This study reports on biallelic homozygous and monoallelic de novo variants in SLITRK3 in three unrelated families presenting with epileptic encephalopathy associated with a broad neurological involvement characterized by microcephaly, intellectual d
Externí odkaz:
https://doaj.org/article/4c9fba0e92c64e6881b4e82760b9b3c3
Autor:
Minoru Hatayama, Kei-ichi Katayama, Yukie Kawahara, Hayato Matsunaga, Noriko Takashima, Yoshimi Iwayama, Yoshifumi Matsumoto, Akinori Nishi, Takeo Yoshikawa, Jun Aruga
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Loss of SLITRK1 results in altered behaviour and in increased noradrenergic projections in OCD-related neural circuits, suggesting that differences in noradrenergic signaling may contribute to numerous neurodevelopmental disorders, including OCD, sch
Externí odkaz:
https://doaj.org/article/a336a2a8d47249c0ba8e7d324f5d1a23
Autor:
Minoru Hatayama, Jun Aruga
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
SLITRK1 is a neuronal transmembrane protein with neurite development-and synaptic formation-controlling abilities. Several rare variants of SLITRK1 have been identified and implicated in the pathogenesis of Tourette’s syndrome, trichotillomania, an
Externí odkaz:
https://doaj.org/article/41166633695e4b7ca3cf41c54fce223a
Autor:
Kei-ichi Katayama, Naoko Morimura, Katsunori Kobayashi, Danielle Corbett, Takehito Okamoto, Veravej G. Ornthanalai, Hayato Matsunaga, Wakako Fujita, Yoshifumi Matsumoto, Takumi Akagi, Tsutomu Hashikawa, Kazuyuki Yamada, Niall P. Murphy, Soichi Nagao, Jun Aruga
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104604- (2022)
Summary: SLITRK2 encodes a transmembrane protein that modulates neurite outgrowth and synaptic activities and is implicated in bipolar disorder. Here, we addressed its physiological roles in mice. In the brain, the Slitrk2 protein was strongly detect
Externí odkaz:
https://doaj.org/article/4c551bbb671f4e9d99a3161fe1d0f72d
Autor:
Misato Ichise, Kazuto Sakoori, Kei-ichi Katayama, Naoko Morimura, Kazuyuki Yamada, Hiroki Ozawa, Hayato Matsunaga, Minoru Hatayama, Jun Aruga
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
The striatum is involved in action selection, and its disturbance can cause movement disorders. Here, we show that leucine-rich repeats and transmembrane domain 2 (Lrtm2) controls protein sorting in striatal projection systems, and its deficiency cau
Externí odkaz:
https://doaj.org/article/fa4b4d5bba87434b9ad26127ce23e552
Trans-Synaptic Regulation of Metabotropic Glutamate Receptors by Elfn Proteins in Health and Disease
Autor:
Hayato Matsunaga, Jun Aruga
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2021)
Trans-regulation of G protein-coupled receptors (GPCRs) by leucine-rich repeat (LRR) transmembrane proteins has emerged as a novel type of synaptic molecular interaction in the last decade. Several studies on LRR–GPCR interactions have revealed the
Externí odkaz:
https://doaj.org/article/e333d3eda35947e9b6351eb52ade96c8
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245624 (2021)
LRFN2 encodes a synaptic adhesion-like molecule that physically interacts with N-methyl-D-aspartate (NMDA) receptor 1 and its scaffold proteins. Previous studies in humans and mice have demonstrated its genetic association with neurodevelopmental dis
Externí odkaz:
https://doaj.org/article/543f97e0d9f54f848e8554f6bf9d5f3b
Autor:
Daisuke Watanabe, Shinsuke Nakagawa, Yoichi Morofuji, Andrea E. Tóth, Monika Vastag, Jun Aruga, Masami Niwa, Mária A. Deli
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1484 (2021)
Culture models of the blood-brain barrier (BBB) are important research tools. Their role in the preclinical phase of drug development to estimate the permeability for potential neuropharmaceuticals is especially relevant. Since species differences in
Externí odkaz:
https://doaj.org/article/5037a67068124f8a9f3250bedf407a56
Autor:
Naoko Morimura, Hiroki Yasuda, Kazuhiko Yamaguchi, Kei-ichi Katayama, Minoru Hatayama, Naoko H. Tomioka, Maya Odagawa, Akiko Kamiya, Yoshimi Iwayama, Motoko Maekawa, Kazuhiko Nakamura, Hideo Matsuzaki, Masatsugu Tsujii, Kazuyuki Yamada, Takeo Yoshikawa, Jun Aruga
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Lrfn2/SALM1 is a synaptic adhesion molecule, and is known to interact with PSD-95. Here the authors show that Lrfn2 regulates excitatory synapse maturation and maintenance, and that Lrfn2 knockout mice exhibit autism-like behaviours as well as enhanc
Externí odkaz:
https://doaj.org/article/1acb992c3c7f417085fb67cf1cfeb33b