Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jun Akaogi"'
Autor:
Toshiko Shibata-Nozaki, Hiroshi Ito, Hirofumi Mitomi, Takayuki Maruyama, So Nomoto, Hidehiro Yamada, Tatsuya Komagata, Toshiya Kanaji, Toshihito Mori, Shoichi Ozaki, Jun Akaogi
Publikováno v:
Arthritis & Rheumatism. 63:2595-2605
Objective We recently developed an ex vivo cellular model of pannus, the aberrant overgrowth of human synovial tissue. This study was undertaken to use that model to investigate the role of prostaglandin E2 (PGE2) and its receptor subtypes in the dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6aaee34708c5861452a30f2015d782d
https://doi.org/10.1002/art.30428
https://doi.org/10.1002/art.30428
Autor:
Edward K. L. Chan, Mark S. Segal, Westley H. Reeves, Eric S. Sobel, Prasanthi Kakumanu, Sonali Narain, Yoshioki Yamasaki, Jun Akaogi, Paulette Hahn, Yi Li, Minoru Satoh
Publikováno v:
The Journal of Rheumatology. 36:2682-2690
Objective.Anti-cyclic citrullinated peptide (CCP) antibodies are a serological marker for rheumatoid arthritis (RA); up to 10%–15% of patients with systemic lupus erythematosus (SLE) are also positive. While anti-CCP in RA is citrulline-dependent,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a498f3b773dcbc3d70cbf025fc8b31e
https://doi.org/10.3899/jrheum.090338
https://doi.org/10.3899/jrheum.090338
Autor:
Haoyang Zhuang, Westley H. Reeves, Yi Li, Pui Y. Lee, Kindra M. Kelly, Jason S. Weinstein, Minoru Satoh, Yoshiki Kuroda, Jun Akaogi, Dina C. Nacionales, Eric S. Sobel
Publikováno v:
The American Journal of Pathology. 168:1227-1240
Lymphoid neogenesis is associated with antibody-mediated autoimmune diseases such as Sjogren's syndrome and rheumatoid arthritis. Although systemic lupus erythematosus is the prototypical B-cell-mediated autoimmune disease, the role of lymphoid neoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330bc8108cf1ee0aefbcf061011b2d99
https://doi.org/10.2353/ajpath.2006.050125
https://doi.org/10.2353/ajpath.2006.050125
Autor:
Yoshioki Yamasaki, Jun Akaogi, Westley H. Reeves, Nobutaka Ono, Yoshiki Kuroda, Minoru Satoh, Dina C. Nacionales, Tolga Barker
Publikováno v:
Toxicology. 218:186-196
A single intraperitoneal (i.p.) injection of pristane, incomplete Freund's adjuvant (IFA), or the adjuvant oil squalene, but not high molecular weight medicinal mineral oils, induces lupus-related autoantibodies to nRNP/Sm and -Su in non-autoimmune s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1536ff37b4b42cc96da657be763c89c5
https://doi.org/10.1016/j.tox.2005.10.011
https://doi.org/10.1016/j.tox.2005.10.011
Autor:
Dina C. Nacionales, Jun Akaogi, Pui Lee, Bryan R.G. Williams, Minoru Satoh, Kindra M. Kelly, Shizou Akira, Philip O. Scumpia, Masahiro Yamamoto, Robert Lyons, Westley H. Reeves, Haoyang Zhuang
Publikováno v:
Arthritis & Rheumatism. 54:1557-1567
Objective Most lupus patients produce autoantibodies against small ribonucleoproteins such as Sm/RNP and Ro 60 (containing U1 and Y1–Y5 RNAs, respectively). We undertook this study to investigate whether the RNA components of these antigens, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dc404399ddee9effab552efabbddab
https://doi.org/10.1002/art.21819
https://doi.org/10.1002/art.21819
Autor:
Michito Hirakata, Jun Akaogi, Westley H. Reeves, Nobutaka Ono, Yoshiki Kuroda, Yoshioki Yamasaki, Victoria M. Shaheen, Akiei Mizutani, Hideo Yoshida, Minoru Satoh, Dina C. Nacionales
Publikováno v:
Clinical Immunology. 114:110-118
Hypergammaglobulinemia and autoantibodies are reduced in pristane-treated specific pathogen-free mice vs. conventionally housed controls, consistent with the role of microbial stimulation in this model. To determine whether microbial stimulation is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0282f55cc010b3a2fd92e001e783f3
https://doi.org/10.1016/j.clim.2004.09.010
https://doi.org/10.1016/j.clim.2004.09.010
Publikováno v:
Biomedicine & Pharmacotherapy. 58:325-337
Adjuvant oils such as Bayol F (Incomplete Freund's adjuvant: IFA) and squalene (MF59) have been used in human and veterinary vaccines despite poor understanding of their mechanisms of action. Several reports suggest an association of vaccination and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d0d1b70fc180e032100386bcf2b182
https://doi.org/10.1016/j.biopha.2004.04.009
https://doi.org/10.1016/j.biopha.2004.04.009
Autor:
Yoshiki Kuroda, Scott C. Wasdo, Westley H. Reeves, Nancy J. Szabo, Dina C. Nacionales, Jun Akaogi, Minoru Satoh
Publikováno v:
Toxicological Sciences. 78:222-228
Although mineral oils are generally considered nontoxic and have a long history of use in humans, the mineral oil Bayol F (incomplete Freund's adjuvant, IFA) and certain mineral oil components (squalene and n-hexadecane) induce lupus-related anti-nRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96d457e764a71d740c4cf51261a39a4
https://doi.org/10.1093/toxsci/kfh063
https://doi.org/10.1093/toxsci/kfh063
Autor:
Westley H. Reeves, Robert J. Rosenbauer, Thomas D. Lorenson, Yoshiki Kuroda, Jun Akaogi, Akiei Mizutani, Krista M. Behney, Hideo Yoshida, Minoru Satoh, Dina C. Nacionales
Publikováno v:
Journal of Autoimmunity. 21:1-9
Exposure to the hydrocarbon oil pristane induces lupus specific autoantibodies in non-autoimmune mice. We investigated whether the capacity to induce lupus-like autoimmunity is a unique property of pristane or is shared by other adjuvant oils. Seven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667bc34906b8d768b27fd0e3303ae8be
https://doi.org/10.1016/s0896-8411(03)00083-0
https://doi.org/10.1016/s0896-8411(03)00083-0
Autor:
N. Hama, Mitsubumi Abe, Tomohiko Shibata, Shoichi Ozaki, Hidehiro Yamada, Jun Akaogi, Masako Mizoguchi, Emiko Yamasaki
Publikováno v:
Modern rheumatology. 12(2)
We present a rare case of simultaneous muscle weakness and cutaneous depigmentation. Muscle and skin biopsies confirmed the diagnosis of polymyositis and generalized vitiligo vulgaris. All symptoms improved after steroid therapy. Immunohistochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7015a81433a575a96c0b46b60f737bfa
https://pubmed.ncbi.nlm.nih.gov/24383911
https://pubmed.ncbi.nlm.nih.gov/24383911