Zobrazeno 1 - 10
of 330
pro vyhledávání: '"Jun Adachi"'
Autor:
Koji Hosomi, Noritoshi Hatanaka, Atsushi Hinenoya, Jun Adachi, Yoko Tojima, Mari Furuta, Keita Uchiyama, Makiko Morita, Takahiro Nagatake, Azusa Saika, Soichiro Kawai, Ken Yoshii, Saki Kondo, Shinji Yamasaki, Jun Kunisawa
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionCampylobacter spp. are a public health concern, yet there is still no effective vaccine or medicine available.MethodsHere, we developed a Campylobacter jejuni-specific antibody and found that it targeted a menaquinol cytochrome c reductas
Externí odkaz:
https://doaj.org/article/377cf10cccfd4ba19f78854bf5fa0d34
Autor:
Mei Tomoto, Yohei Mineharu, Noriaki Sato, Yoshinori Tamada, Mari Nogami-Itoh, Masataka Kuroda, Jun Adachi, Yoshito Takeda, Kenji Mizuguchi, Atsushi Kumanogoh, Yayoi Natsume-Kitatani, Yasushi Okuno
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by severe lung fibrosis and a poor prognosis. Although the biomolecules related to IPF have been extensively studied, molecular mechanisms of the pathogenesis and the
Externí odkaz:
https://doaj.org/article/046eef4039e1435694fbc33987598267
Autor:
Takehiro Tozuka, MD, Rintaro Noro, MD, PhD, Keisuke Yoshida, PhD, Satoshi Takahashi, MD, PhD, Mariko Hirao, MD, Kuniko Matsuda, MD, Yasuhiro Kato, MD, Shinji Nakamichi, MD, PhD, Susumu Takeuchi, MD, PhD, Masaru Matsumoto, MD, PhD, Akihiko Miyanaga, MD, PhD, Shinobu Kunugi, MD, PhD, Kazufumi Honda, DDS, PhD, Jun Adachi, PhD, Masahiro Seike, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 4, Pp 100668- (2024)
Introduction: Osimertinib is a standard treatment for patients with EGFR-mutant NSCLC. Although some osimertinib resistance mechanisms have been identified, nearly 50% of the mechanisms remain to be elucidated. This study was aimed at identifying non
Externí odkaz:
https://doaj.org/article/28ffabd2f77f47d7942680f03c8b460c
Autor:
Taichi Igarashi, Marianne Mazevet, Takaaki Yasuhara, Kimiyoshi Yano, Akifumi Mochizuki, Makoto Nishino, Tatsuya Yoshida, Yukihiro Yoshida, Nobuhiko Takamatsu, Akihide Yoshimi, Kouya Shiraishi, Hidehito Horinouchi, Takashi Kohno, Ryuji Hamamoto, Jun Adachi, Lee Zou, Bunsyo Shiotani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Activation of the KRAS oncogene is a source of replication stress, but how this stress is generated and how it is tolerated by cancer cells remain poorly understood. Here we show that induction of KRASG12V expression in untransformed cells t
Externí odkaz:
https://doaj.org/article/43f90e5e10dd446096f58be5f96dcc74
Autor:
Tomoko Dai, Jun Adachi, Yuichi Dai, Noriyuki Nakano, Mariko Yamato, Shinji Kikuchi, Shingo Usui, Yuko Minami, Takeshi Tomonaga, Masayuki Noguchi, Daisuke Matsubara, Noriaki Sakamoto
Publikováno v:
Cancer Medicine, Vol 12, Iss 9, Pp 10755-10767 (2023)
Abstract Introduction Lung adenocarcinoma progresses stepwise from atypical adenomatous hyperplasia to adenocarcinoma in situ (AIS), followed by minimally invasive adenocarcinoma (MIA), and then obvious invasive adenocarcinoma. In this study, we exam
Externí odkaz:
https://doaj.org/article/6b5d00465ed841a1a5137f3e1eae4c24
Autor:
Keiko Kasahara, Ryohei Narumi, Satoshi Nagayama, Keiko Masuda, Tsuyoshi Esaki, Kazutaka Obama, Takeshi Tomonaga, Yoshiharu Sakai, Yoshihiro Shimizu, Jun Adachi
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 7616-7626 (2023)
Abstract Purpose The pathogenesis of cancers depends on the molecular background of each individual patient. Therefore, verifying as many biomarkers as possible and clarifying their relationships with each disease status would be very valuable. We pe
Externí odkaz:
https://doaj.org/article/9dcc0f8c635348a9b9c2ce58f85e379f
Autor:
Takeshi Kameyama, Muneaki Miyata, Hajime Shiotani, Jun Adachi, Soichiro Kakuta, Yasuo Uchiyama, Kiyohito Mizutani, Yoshimi Takai
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108010- (2023)
Summary: Astrocytes interact with not only synapses but also brain blood vessels through perivascular astrocyte endfeet (PV-AEF) to form the neurovascular unit (NVU). However, PV-AEF components have not been fully identified. Here, we biochemically i
Externí odkaz:
https://doaj.org/article/284f87b094cb43ccba6d8301bf19a4f1
Autor:
Yosui Nojima, Masahiko Aoki, Suyong Re, Hidekazu Hirano, Yuichi Abe, Ryohei Narumi, Satoshi Muraoka, Hirokazu Shoji, Kazufumi Honda, Takeshi Tomonaga, Kenji Mizuguchi, Narikazu Boku, Jun Adachi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2172-2187 (2023)
Apatinib is known to be a highly selective vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with anti-angiogenic and anti-tumor properties. In a phase III study, the objective response rate to apatinib was low. It remains unclear why
Externí odkaz:
https://doaj.org/article/96f2d6f634004bf692af38e6773e75d9
Autor:
Masahiro Oka, Mayumi Otani, Yoichi Miyamoto, Rieko Oshima, Jun Adachi, Takeshi Tomonaga, Munehiro Asally, Yuya Nagaoka, Kaori Tanaka, Atsushi Toyoda, Kazuki Ichikawa, Shinichi Morishita, Kyoichi Isono, Haruhiko Koseki, Ryuichiro Nakato, Yasuyuki Ohkawa, Yoshihiro Yoneda
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112884- (2023)
Summary: NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated nuclear bodies containing CRM1, a nuclear export receptor. However, these nuclear bodies’ function in controlling gene expression remains elusive. Here, we d
Externí odkaz:
https://doaj.org/article/27e794921f7543668100a9de7b8c9a5b
Autor:
Takahiro Kawasaki, Yoshito Takeda, Ryuya Edahiro, Yuya Shirai, Mari Nogami-Itoh, Takanori Matsuki, Hiroshi Kida, Takatoshi Enomoto, Reina Hara, Yoshimi Noda, Yuichi Adachi, Takayuki Niitsu, Saori Amiya, Yuta Yamaguchi, Teruaki Murakami, Yasuhiro Kato, Takayoshi Morita, Hanako Yoshimura, Makoto Yamamoto, Daisuke Nakatsubo, Kotaro Miyake, Takayuki Shiroyama, Haruhiko Hirata, Jun Adachi, Yukinori Okada, Atsushi Kumanogoh
Publikováno v:
Inflammation and Regeneration, Vol 42, Iss 1, Pp 1-19 (2022)
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic is widespread; however, accurate predictors of refractory cases have not yet been established. Circulating extracellular vesicles, involved in many pathological processes, are ideal
Externí odkaz:
https://doaj.org/article/77f6618fb474472ab013b5ae1a42c451