Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Jun‐ichi Kawabe"'
Autor:
Takashi Yazawa, Yugo Watanabe, Yuko Yokohama, Yoshitaka Imamichi, Kazuya Hasegawa, Ke-ichi Nakajima, Takeshi Kitano, Takanori Ida, Takahiro Sato, Mohammad Sayful Islam, Akihiro Umezawa, Satoru Takahashi, Yasuhito Kato, Sharmin Jahan, Jun-ichi Kawabe
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
3β-Hydroxysteroid dehydrogenases (3β-HSDs) catalyze the oxidative conversion of delta (5)-ene-3-beta-hydroxy steroids and ketosteroids. Human 3β-HSD type 2 (HSD3B2) is predominantly expressed in gonadal and adrenal steroidogenic cells for producin
Externí odkaz:
https://doaj.org/article/8b8186365c784724afed80dc9e31ad03
Autor:
Hirofumi Sakuma, Keisuke Maruyama, Tatsuya Aonuma, Yuya Kobayashi, Taiki Hayasaka, Kohei Kano, Satoshi Kawaguchi, Kei-ichi Nakajima, Jun-ichi Kawabe, Naoyuki Hasebe, Naoki Nakagawa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract MicroRNAs (miRNAs) are sequence-specific inhibitors of post-transcriptional gene expression. However, the physiological functions of these non-coding RNAs in renal interstitial mesenchymal cells remain unclear. To conclusively evaluate the r
Externí odkaz:
https://doaj.org/article/b9e38ada6f4d44668100fcaf8eb11d2c
Autor:
Takamitsu Tatsukawa, Kohei Kano, Kei-ichi Nakajima, Takashi Yazawa, Ryoji Eguchi, Maki Kabara, Kiwamu Horiuchi, Taiki Hayasaka, Risa Matsuo, Naoyuki Hasebe, Nobuyoshi Azuma, Jun-ichi Kawabe
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Skeletal muscle comprises almost 40% of the human body and is essential for movement, structural support and metabolic homeostasis. Size of multinuclear skeletal muscle is stably maintained under steady conditions with the sporadi
Externí odkaz:
https://doaj.org/article/1c87004fecaf4f1586d46cc9af202d0d
Autor:
Takanori Sano, Tadaaki Nakajima, Koharu Alicia Senda, Shizuka Nakano, Mizuho Yamato, Yukinori Ikeda, Hedele Zeng, Jun-ichi Kawabe, Yukiko T. Matsunaga
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Background Sprouting angiogenesis is an important mechanism for morphogenetic phenomena, including organ development, wound healing, and tissue regeneration. In regenerative medicine, therapeutic angiogenesis is a clinical solution for recov
Externí odkaz:
https://doaj.org/article/8d250f3c824d489ca2b6c9cd71a98f4b
Autor:
Kazuo Yamasaki, Takashi Daiho, Satoshi Yasuda, Stefania Danko, Jun-ichi Kawabe, Hiroshi Suzuki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Arg324 of sarcoplasmic reticulum Ca2+-ATPase forms electrostatic interactions with the phosphate moiety of phospholipids in most reaction states, and a hydrogen bond with Tyr122 in other states. Using site-directed mutagenesis, we explored t
Externí odkaz:
https://doaj.org/article/cde8cc0e189a45628f84d8db218ab550
Autor:
Taiki Hayasaka, Naofumi Takehara, Tatsuya Aonuma, Kohei Kano, Kiwamu Horiuchi, Naoki Nakagawa, Hiroki Tanaka, Jun-ichi Kawabe, Naoyuki Hasebe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Sarcopenia is a pathophysiological malfunction induced by skeletal muscle atrophy. Several studies reported an association between sarcopenia-induced cardiac cachexia and poor prognosis in heart disease. However, due to lack of an establishe
Externí odkaz:
https://doaj.org/article/21408efedb4047458e9a444d4887fba1
Autor:
Risa Matsuo, Mari Kishibe, Kiwamu Horiuchi, Kohei Kano, Takamitsu Tatsukawa, Taiki Hayasaka, Maki Kabara, Shin Iinuma, Ryoji Eguchi, Satomi Igawa, Naoyuki Hasebe, Akemi Ishida-Yamamoto, Jun-ichi Kawabe
Publikováno v:
JID Innovations, Vol 2, Iss 6, Pp 100141- (2022)
The formation of mature vasculature through angiogenesis is essential for adequate wound healing, such that blood-borne cells, nutrients, and oxygen can be delivered to the remodeling skin area. Neovessel maturation is highly dependent on the coordin
Externí odkaz:
https://doaj.org/article/ec5e398184bb446aa6b253713e9dfaa0
Autor:
Yuri Yoshida, Maki Kabara, Kohei Kano, Kiwamu Horiuchi, Taiki Hayasaka, Yui Tomita, Naofumi Takehara, Akiho Minoshima, Tatsuya Aonuma, Keisuke Maruyama, Naoki Nakagawa, Nobuyoshi Azuma, Naoyuki Hasebe, Jun‐ichi Kawabe
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 1, Pp 120-130 (2020)
Abstract The presence of pericytes (PCs) with multipotency and broad distribution along capillary suggests that microvasculature plays a role not only as a duct for blood fluid transport but also as a stem cell niche that contributes to tissue mainte
Externí odkaz:
https://doaj.org/article/a545c378a2c642c281fa74242d39a686
Autor:
Keisuke Maruyama, Naoki Nakagawa, Tatsuya Aonuma, Yukihiro Saito, Taiki Hayasaka, Kohei Kano, Kiwamu Horiuchi, Naofumi Takehara, Jun-ichi Kawabe, Naoyuki Hasebe
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein that controls the cellular response to oxidative stress and possesses DNA-repair functions. It has important roles in the progression and outcomes of various diseases;
Externí odkaz:
https://doaj.org/article/aa537171877b4893a52a547f79f37b75
Autor:
Kohei Kano, Kiwamu Horiuchi, Yuri Yoshida, Taiki Hayasaka, Maki Kabara, Yui Tomita, Takamitsu Tatsukawa, Risa Matsuo, Jun Sawada, Naoki Nakagawa, Naofumi Takehara, Naoyuki Hasebe, Jun-ichi Kawabe
Publikováno v:
Stem Cell Research, Vol 47, Iss , Pp 101914- (2020)
Skeletal muscle has a capacity for muscular regeneration mediated by satellite cells (SCs) and non-SCs. Although it is proposed that non-SCs are attractive therapeutic targets for dystrophies, the biological properties of these cells remain unclear.
Externí odkaz:
https://doaj.org/article/d9d5eda1f5f54dcd87cde1543caed1b7