Výsledky vyhledávání - "Jun‐Nan Hu"

Akademický článek

Tangeretin, an active flavonoid in citrus peel, alleviates cisplatin-induced cardiotoxicity via the activation of AMPK and the prevention on mitochondrial dysfunction

Autor: Jian-qiang Wang, Ruo-bing Zhang, Jun-nan Hu, Jing-jing Xing, Shan Tang, Si-wen Zheng, Feng-jie Lei, Li-chun Zhao, Zi Wang, Wei Li

Publikováno v: Journal of Functional Foods, Vol 120, Iss , Pp 106364- (2024)

Cardiotoxicity is a common side effect of cisplatin in cancer treatment, often complicating patient care. Tangeretin (TG), a natural compound found in citrus peel, shows promise in protecting against cisplatin-induced heart damage. Our study investig

Externí odkaz: https://doaj.org/article/0813b9015c224d24bacc613faa3dfeef

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Akademický článek

Oral hydrogel microspheres were used for highly specific delivery of Steamed Codonopsis lanceolata to exert the protective effects on cisplatin-induced acute kidney injury in mice

Autor: Yan-fei Li, Wei Li, Jun-nan Hu, Hui Shi, Qiong Shen, Shi-han Wang, Shuang Jiang, Yong-bo Liu, Li-chun Zhao, Zi Wang

Publikováno v: Journal of Functional Foods, Vol 102, Iss , Pp 105431- (2023)

Although Steamed Codonopsis lanceolata (SCL) has been shown to protect against acute kidney injury (AKI), Its poor stability and susceptibility to decomposition in the GI tract significantly reducing its therapeutic efficacy. Nanoscale/microscale dru

Externí odkaz: https://doaj.org/article/7a579c71213a468da20b9848e6497ffd

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Akademický článek

Based on network pharmacology and molecular docking to explore the protective effect of Epimedii Folium extract on cisplatin-induced intestinal injury in mice

Autor: Juan Xia, Jun-Nan Hu, Zi Wang, En-Bo Cai, Shen Ren, Ying-Ping Wang, Xiu-Juan Lei, Wei Li

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Background: Epimedii Folium, as a natural botanical medicine, has been reported to have protective effects on intestinal diseases by modulating multiple signaling pathways. This study aimed to explore the potential targets and molecular mechanisms of

Externí odkaz: https://doaj.org/article/4634269646aa40129abf05a4ad921005

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Akademický článek

Maltol, a naturally occurring flavor enhancer, ameliorates cisplatin-induced apoptosis by inhibiting NLRP3 inflammasome activation by modulating ROS-mediated oxidative stress

Autor: Wen-ting Wang, Mei-ling Fan, Jun-nan Hu, Ji-yue Sha, Hao Zhang, Zi Wang, Jun-jie Zhang, Shi-Han Wang, Si-wen Zheng, Wei Li

Publikováno v: Journal of Functional Foods, Vol 94, Iss , Pp 105127- (2022)

Although the antagonistic effects of saponins (Ginsenosides) from ginseng on the side effects caused by cisplatin have been widely confirmed, there are few reports on the non-saponins of small molecules. Maltol, as an important active ingredient and

Externí odkaz: https://doaj.org/article/3162446742ff4983a3e14b6259927768

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Akademický článek

Protective effect of ginsenoside Rk1, a major rare saponin from black ginseng, on cisplatin‐induced nephrotoxicity in HEK‐293 cells

Autor: Jun‐Nan Hu, Xing‐Yue Xu, Shuang Jiang, Ying Liu, Zhi Liu, Ying‐Ping Wang, Xiao‐Jie Gong, Ke‐Ke Li, Shen Ren, Wei Li

Publikováno v: Kaohsiung Journal of Medical Sciences, Vol 36, Iss 9, Pp 732-740 (2020)

Abstract Cisplatin, as one of the most effective chemotherapeutic agents, its clinical use is limited by serious side effect of nephrotoxicity. Cisplatin‐induced nephrotoxicity is closely related to apoptosis induction and activation of caspase. Th

Externí odkaz: https://doaj.org/article/85cbfe6cd9d64f929e81247089cf13ea

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Akademický článek

Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis

Autor: Jun-Nan Hu, Xing-Yue Xu, Wei Li, Yi-Ming Wang, Ying Liu, Zi Wang, Ying-Ping Wang

Publikováno v: Journal of Ginseng Research, Vol 43, Iss 1, Pp 10-19 (2019)

Background: Frequent overdose of paracetamol (APAP) has become the major cause of acute liver injury. The present study was designed to evaluate the potential protective effects of ginsenoside Rk1 on APAP-induced hepatotoxicity and investigate the un

Externí odkaz: https://doaj.org/article/fd29366870194860947e43ad00bdb415

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Akademický článek

The protective effects of maltol on cisplatin-induced nephrotoxicity through the AMPK-mediated PI3K/Akt and p53 signaling pathways

Autor: Xiao-jie Mi, Jin-gang Hou, Zi Wang, Ye Han, Shen Ren, Jun-nan Hu, Chen Chen, Wei Li

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Abstract Cisplatin, a potent anticancer drug, is usually causing nephrotoxicity; limiting its therapeutic application and efficiency. Maltol may be used to prevent such toxic effect. The aim of this study was to investigate the underlying protective

Externí odkaz: https://doaj.org/article/2ae4566f8538477387f5275278a4aaad

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Akademický článek

Ameliorative Effects and Possible Molecular Mechanism of Action of Black Ginseng (Panax ginseng) on Acetaminophen-Mediated Liver Injury

Autor: Jun-Nan Hu, Zhi Liu, Zi Wang, Xin-Dian Li, Lian-Xue Zhang, Wei Li, Ying-Ping Wang

Publikováno v: Molecules, Vol 22, Iss 4, p 664 (2017)

Background: Frequent overdosing of acetaminophen (APAP) has become the major cause of acute liver injury (ALI). The present study aimed to evaluate the potential hepatoprotective effects of black ginseng (BG) on APAP-induced mice liver injuries and t

Externí odkaz: https://doaj.org/article/e27412aa42b8496b9b12866628bf8213

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