Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jun, Tsukimoto"'
Autor:
Yuto Horii, Toshiki Iniwa, Masayoshi Onitsuka, Jun Tsukimoto, Yuki Tanaka, Hironobu Ike, Yuri Fukushi, Haruna Ando, Yoshie Takeuchi, So-ichiro Nishioka, Daisuke Tsuji, Mariko Ikuo, Naoshi Yamazaki, Yoshiharu Takiguchi, Naozumi Ishimaru, Kohji Itoh
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 297-310 (2022)
Galactosialidosis (GS) is a lysosomal cathepsin A (CTSA) deficiency. It associates with a simultaneous decrease of neuraminidase 1 (NEU1) activity and sialylglycan storage. Central nervous system (CNS) symptoms reduce the quality of life of juvenile/
Externí odkaz:
https://doaj.org/article/c205affe2a714860b2af6ebf4b800e26
Autor:
Hiroki Tanaka, Daisuke Tsuji, Ryosuke Watanabe, Yukiya Ohnishi, Shindai Kitaguchi, Ryuto Nakae, Hiromi Teramoto, Jun Tsukimoto, Yuto Horii, Kohji Itoh
Publikováno v:
Journal of Inherited Metabolic Disease. 45:1191-1202
Lysosomal storage disorders (LSDs) are inherited metabolic diseases caused by genetic defects in lysosomal enzymes or related factors. LSDs are associated with excessive accumulation of natural substrates in lysosomes leading to central nervous syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ba4f2396644c6f080f57a44c2a20a4
https://doi.org/10.1002/jimd.12558
https://doi.org/10.1002/jimd.12558
Autor:
Jun Tsukimoto, Yoshie Takeuchi, Yuto Horii, Toshiki Iniwa, Yuri Fukushi, So-ichiro Nishioka, Kohji Itoh
Publikováno v:
ACS Applied Bio Materials. 5:205-213
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca06e38919d8fd3585b08dfb693684c6
https://doi.org/10.1021/acsabm.1c01043
https://doi.org/10.1021/acsabm.1c01043
Autor:
Kotaro, Koiwai, Jun, Tsukimoto, Tetsuya, Higashi, Fumitaka, Mafuné, Ken, Miyajima, Takanori, Nakane, Naohiro, Matsugaki, Ryuichi, Kato, Serena, Sirigu, Arjen, Jakobi, Matthias, Wilmanns, Michihiro, Sugahara, Tomoyuki, Tanaka, Kensuke, Tono, Yasumasa, Joti, Makina, Yabashi, Osamu, Nureki, Eiichi, Mizohata, Toru, Nakatsu, Eriko, Nango, So, Iwata, Leonard M G, Chavas, Toshiya, Senda, Kohji, Itoh, Fumiaki, Yumoto
Publikováno v:
ACS applied bio materials. 2(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::258df8a5a84ac6eedae5418ed1fa9d84
https://pubmed.ncbi.nlm.nih.gov/35021494
https://pubmed.ncbi.nlm.nih.gov/35021494
Autor:
Jun, Tsukimoto, Yoshie, Takeuchi, Yuto, Horii, Toshiki, Iniwa, Yuri, Fukushi, So-Ichiro, Nishioka, Kohji, Itoh
Publikováno v:
ACS applied bio materials. 5(1)
Human neuraminidase 1 (NEU1) is a lysosomal glycosidase that cleaves the terminal sialic acids of sialylglycoconjugates. NEU1 is biosynthesized in the endoplasmic reticulum (ER) lumen as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::403812f55791cf96a89c482b44fc5889
https://pubmed.ncbi.nlm.nih.gov/35014832
https://pubmed.ncbi.nlm.nih.gov/35014832
Autor:
Akira Shigenaga, Chiaki Komiya, Jun Tsukimoto, Takuya Morisaki, Akira Otaka, Kohji Itoh, Masahiro Ueda, Tsubasa Inokuma
Publikováno v:
Chemical Communications. 55(49):7029-7032
A traceless thioester-producing protocol featuring carboxypeptidase Y-mediated hydrazinolysis of cysteinyl prolyl leucine-tagged peptides has been developed. The hydrazinolysis followed by thioesterification affords cysteinyl prolyl thioesters. Self-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b876049d3f830caabf3ab9dff32053d0
http://repo.lib.tokushima-u.ac.jp/113348
http://repo.lib.tokushima-u.ac.jp/113348
Autor:
Miki Ueno, Eiji Nanba, Hideki Nakajima, Kaori Adachi, A. Kawakami, Aya Narita, Kohji Itoh, Jun Tsukimoto
Publikováno v:
Human Genome Variation, Vol 6, Iss 1, Pp 1-5 (2019)
Human Genome Variation
Human Genome Variation
Galactosialidosis is an autosomal recessive lysosomal storage disease caused by the combined deficiency of lysosomal β-galactosidase and neuraminidase due to a defect in the protective protein/cathepsin A. Patients present with various clinical mani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362c232a249b9d04cb50a5847f6216bc
http://link.springer.com/article/10.1038/s41439-019-0054-x
http://link.springer.com/article/10.1038/s41439-019-0054-x
Autor:
Yuri Fukushi, Yuuto Horii, Daisuke Tsuji, Toshiki Iniwa, Haruna Ando, Kohji Itoh, Jun Tsukimoto
Publikováno v:
Molecular Genetics and Metabolism. 129:S78-S79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edae9851e8e65e6591c8d727500d4332
https://doi.org/10.1016/j.ymgme.2019.11.191
https://doi.org/10.1016/j.ymgme.2019.11.191
Autor:
Mustafizur Rahman, Seiji Hitaoka, Daisuke Tsuji, Takatsugu Hirokawa, Tatsusada Yoshida, Jun Tsukimoto, Kohji Itoh, Hiroshi Chuman
Publikováno v:
Biochemistry and Biophysics Reports
Human cytosolic sialidase (Neuraminidase 2, NEU2) catalyzes the removal of terminal sialic acid residues from glycoconjugates. The effect of siastatin B, known as a sialidase inhibitor, has not been evaluated toward human NEU2 yet. We studied the reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f84189d3fdc69fc3d44327f43883dd1
https://doi.org/10.1016/j.bbrep.2015.09.017
https://doi.org/10.1016/j.bbrep.2015.09.017