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Akademický článek

Thrombus leukocytes exhibit more endothelial cell-specific angiogenic markers than peripheral blood leukocytes do in acute coronary syndrome patients, suggesting a possibility of trans-differentiation: a comprehensive database mining study

Autor: Hangfei Fu, Nish Vadalia, Eric R. Xue, Candice Johnson, Luqiao Wang, William Y. Yang, Claudette Sanchez, Jun Nelson, Qian Chen, Eric T. Choi, Jian-Xing Ma, Jun Yu, Hong Wang, Xiaofeng Yang

Publikováno v: Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-21 (2017)

Abstract Background Current angiogenic therapies for cancers and cardiovascular diseases have not yet achieved expected benefits, which reflects the need for improved understanding of angiogenesis. In this study, we focused on solving the problem of

Externí odkaz: https://doaj.org/article/82acf15a6e2b4277874048672e752025

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Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair

Autor: Ying Yin, Xiaofeng Yang, Jun Nelson, Hong Wang, Xiaohua Jiang, Xiao Huang, Ya-Feng Li, Ren Gong, Xinyuan Li, Erhe Gao, Congxin Huang, Nicholas E. Hoffman, Douglas G. Tilley, Muniswamy Madesh, Hongyu Zhang, Eric T. Choi, Steven R. Houser

Publikováno v: Scopus-Elsevier

Caspase-1 activation senses metabolic danger-associated molecular patterns (DAMPs) and mediates the initiation of inflammation in endothelial cells. Here, we examined whether the caspase-1 pathway is responsible for sensing hyperlipidemia as a DAMP i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53073da2785fee34b47b0ebacc7603c4
https://doi.org/10.2741/4383

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Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis

Autor: Hang Xi, Ya-Feng Li, P. I. Imoukhuede, Xinyuan Li, Xinyu Xiong, Jahaira Lopez-Pastrana, Hong Tian Wang, Lucas M. Ferrer, Xuebin Qin, Eric T. Choi, Ann L Cannella, Xiaojin Sha, Xiaofeng Yang, Jun Nelson, Ramon Cueto

Publikováno v: Journal of Biological Chemistry. 290:17485-17494

Deficient angiogenesis may contribute to worsen the prognosis of myocardial ischemia, peripheral arterial disease, ischemic stroke, etc. Dyslipidemic and inflammatory environments attenuate endothelial cell (EC) proliferation and angiogenesis, worsen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f08b64986170a2a9e2dfcd6da50554a
https://doi.org/10.1074/jbc.m115.641191

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Hyperhomocysteinemia suppresses bone marrow CD34 + /VEGF receptor 2 + cells and inhibits progenitor cell mobilization and homing to injured vasculature—a role of β1‐integrin in progenitor cell migration and adhesion

Autor: Jun Nelson, Remus M. Berretta, Jingfeng Wang, Hong Wang, Yi Wu, Steven R. Houser, Jian Huang, Eric T. Choi, Xiaohua Jiang, Xiaofeng Yang

Publikováno v: The FASEB Journal. 29:3085-3099

Hyperhomocysteinemia (HHcy) impairs re-endothelialization and accelerates vascular remodeling. The role of CD34(+)/VEGF receptor (VEGFR) 2(+) progenitor cells (PCs) in vascular repair in HHcy is unknown. We studied the effect of HHcy on PCs and its r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b8922e6ad46a2975f9888a61a96590a
https://doi.org/10.1096/fj.14-267989

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Severe Hyperhomocysteinemia Promotes Bone Marrow–Derived and Resident Inflammatory Monocyte Differentiation and Atherosclerosis in LDLr/CBS-Deficient Mice

Autor: Pu Fang, Jodene K. Moore, Warren D. Kruger, Steven R. Houser, Xiaohua Jiang, Xiaofeng Yang, Daqing Zhang, Hong Wang, Jun Nelson, Remus M. Berretta

Publikováno v: Circulation Research. 111:37-49

Rationale: Hyperhomocysteinemia (HHcy) accelerates atherosclerosis and increases inflammatory monocytes (MC) in peripheral tissues. However, its causative role in atherosclerosis is not well established and its effect on vascular inflammation has not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c27b09a0118622bcbd4f8ef5e1ab478
https://doi.org/10.1161/circresaha.112.269472

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Hyperhomocysteinemia suppresses bone marrow CD34+/VEGF receptor 2+ cells and inhibits progenitor cell mobilization and homing to injured vasculature-a role of β1-integrin in progenitor cell migration and adhesion

Autor: Jun, Nelson, Yi, Wu, Xiaohua, Jiang, Remus, Berretta, Steven, Houser, Eric, Choi, Jingfeng, Wang, Jian, Huang, Xiaofeng, Yang, Hong, Wang

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(7)

Hyperhomocysteinemia (HHcy) impairs re-endothelialization and accelerates vascular remodeling. The role of CD34+/VEGF receptor (VEGFR) 2+ progenitor cells (PCs) in vascular repair in HHcy is unknown. We studied the effect of HHcy on PCs and its role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c56304e96d8a0fc37067607d6eae0da9
https://pubmed.ncbi.nlm.nih.gov/25854700

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