5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions.

Autor: Pätsi HT; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Kilpeläinen TP; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Jumppanen M; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Uhari-Väänänen J; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Wielendaele PV; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Wilrijk, Belgium., De Lorenzo F; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Cui H; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1C, 70211 Kuopio, Finland., Auno S; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Saharinen J; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Seppälä E; School of Medicine/Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 8, Kuopio 70211, Finland., Sipari N; Viikki Metabolomics Unit, Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 5 E, 00014 Helsinki, Finland., Savinainen J; School of Medicine/Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 8, Kuopio 70211, Finland., De Meester I; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Wilrijk, Belgium., Lambeir AM; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Wilrijk, Belgium., Lahtela-Kakkonen M; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1C, 70211 Kuopio, Finland., Myöhänen TT; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1C, 70211 Kuopio, Finland.; Division of Pharmacology, Faculty of Medicine, University of Helsinki, P.O.Box 63, 00014 Helsinki, Finland., Wallén EAA; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Apr 11; Vol. 67 (7), pp. 5421-5436. Date of Electronic Publication: 2024 Mar 28.

PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells.

Autor: Denisova OV; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland., Merisaari J; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland.; Institute of Biomedicine, University of Turku, Finland., Huhtaniemi R; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland., Qiao X; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland., Yetukuri L; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland.; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.; Centre for Biostatistics and Epidemiology (OCBE), University of Oslo, Norway., Jumppanen M; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland., Kaur A; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland., Pääkkönen M; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland., von Schantz-Fant С; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland., Ohlmeyer M; Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Atux Iskay LLC, Plainsboro, NJ, USA., Wennerberg K; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.; Biotech Research & Innovation Centre, University of Copenhagen, Denmark., Kauko O; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland., Koch R; University Medical Center Göttingen, Germany., Aittokallio T; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.; Centre for Biostatistics and Epidemiology (OCBE), University of Oslo, Norway.; Institute for Cancer Research, Oslo University Hospital, Norway., Taipale M; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada., Westermarck J; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland.; Institute of Biomedicine, University of Turku, Finland.

Publikováno v: Molecular oncology [Mol Oncol] 2023 Sep; Vol. 17 (9), pp. 1803-1820. Date of Electronic Publication: 2023 Jul 26.

Toxicity profiling of cardiac transcription factor-targeted compounds in various cardiac and stem cell types reveals cell type-and compound-dependent toxicity

Autor: Karhu, ST, Valimaki, M, Jumppanen, M, Pohjolainen, L, Leigh, R, Foldes, G, Af Gennas, GB, Yli-Kauhaluoma, J, Ruskoaho, H, Talman, V

Publikováno v: 5th Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology
S75

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::3e24df7e57d638bb6f668eaa12d3fddd
http://hdl.handle.net/10044/1/59087

Edible mushroom (Pleurotus cornucopiae) extract vs. glibenclamide on alloxan induced diabetes: sub-acute in vivo study of Nrf2 expression and renal toxicity.

Autor: Uzomba, Chinedu Godwin¹ uzomba.godwin@funai.edu.ng, Ezemagu, Uchenna Kenneth¹, Ofoegbu, Mary-Sonia¹, Lydia, Njoku¹, Goodness, Essien¹, Emelike, Chinedum², Obinna, Uchewa¹, Nwafor, Alo Joseph¹, Mbajiorgu, Ejikeme Felix³

Publikováno v: Anatomy & Cell Biology. Sep2024, Vol. 57 Issue 3, p446-458. 13p.

Biosynthesis of the Bis-Prenylated Alkaloids Muscoride A and B.

Autor: Mattila A; Department of Microbiology , University of Helsinki , P.O. Box 56, Viikki Biocenter, Viikinkaari 9 , FI-00014 Helsinki , Finland., Andsten RM; Department of Microbiology , University of Helsinki , P.O. Box 56, Viikki Biocenter, Viikinkaari 9 , FI-00014 Helsinki , Finland., Jumppanen M; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy , University of Helsinki , P.O. Box 56, Viikinkaari 5 E , FI-00014 Helsinki , Finland., Assante M; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy , University of Helsinki , P.O. Box 56, Viikinkaari 5 E , FI-00014 Helsinki , Finland., Jokela J; Department of Microbiology , University of Helsinki , P.O. Box 56, Viikki Biocenter, Viikinkaari 9 , FI-00014 Helsinki , Finland., Wahlsten M; Department of Microbiology , University of Helsinki , P.O. Box 56, Viikki Biocenter, Viikinkaari 9 , FI-00014 Helsinki , Finland., Mikula KM; Research Program in Structural Biology and Biophysics, Institute of Biotechnology , University of Helsinki , P.O. Box 65, FI-00014 Helsinki , Finland., Sigindere C; Department of Chemistry , University of Pittsburgh , Pittsburgh , Pennsylvania 15260 , United States., Kwak DH; Department of Chemistry , University of Pittsburgh , Pittsburgh , Pennsylvania 15260 , United States., Gugger M; Collection des Cyanobactéries, Département de Microbiologie , Institut Pasteur , 28 Rue du Docteur Roux, 75724 Cedex 15 , 75015 Paris , France., Koskela H; VERIFIN, Department of Chemistry , University of Helsinki , P.O. Box 55, FI-00014 Helsinki , Finland., Sivonen K; Department of Microbiology , University of Helsinki , P.O. Box 56, Viikki Biocenter, Viikinkaari 9 , FI-00014 Helsinki , Finland., Liu X; Department of Chemistry , University of Pittsburgh , Pittsburgh , Pennsylvania 15260 , United States., Yli-Kauhaluoma J; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy , University of Helsinki , P.O. Box 56, Viikinkaari 5 E , FI-00014 Helsinki , Finland., Iwaï H; Research Program in Structural Biology and Biophysics, Institute of Biotechnology , University of Helsinki , P.O. Box 65, FI-00014 Helsinki , Finland., Fewer DP; Department of Microbiology , University of Helsinki , P.O. Box 56, Viikki Biocenter, Viikinkaari 9 , FI-00014 Helsinki , Finland.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2019 Dec 20; Vol. 14 (12), pp. 2683-2690. Date of Electronic Publication: 2019 Nov 19.