An ELISA Using Synthetic Mycolic Acid-Based Antigens with DIVA Potential for Diagnosing Johne’s Disease in Cattle

Autor: Paul S. Mason, Thomas Holder, Natasha Robinson, Brendan Smith, Rwoa’a T. Hameed, Juma’a R. Al Dulayymi, Valerie Hughes, Karen Stevenson, Gareth J. Jones, H. Martin Vordermeier, Shawn Mc Kenna, Mark S. Baird

Publikováno v: Animals, Vol 14, Iss 6, p 848 (2024)

The problem: Ante-mortem diagnosis of Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is normally achieved through faecal culture, PCR, or serological tests, but agreement as to which samples are positive for Johne’s

Externí odkaz: https://doaj.org/article/8f5554f19b794e47bb20d8b4beba08a3

Elevated serum antibody responses to synthetic mycobacterial lipid antigens among UK farmers: an indication of exposure to environmental mycobacteria?

Autor: A. Prysor Williams, James Gibbons, Mark S. Baird, Juma'a R. Al Dulayymi, Alison Jones, Christopher Gwenin, Samuel Fitch, Carys Davies

Publikováno v: RSC Med Chem

Background: mycobacterial cells contain complex mixtures of mycolic acid esters. These can be used as antigens recognised by antibodies in the serum of individuals with active tuberculosis, caused by Mycobacterium tuberculosis. In high burden populat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f0f9317379a622c6ff2db30597d754
https://doi.org/10.1039/d0md00325e

Mycobacterium alvei (ω-1)-methoxy mycolic acids: Absolute stereochemistry and synthesis

Autor: Ahmad R. Al Dulayymi, Zamzam S. Alhuwaymil, Paul J. Gates, Mark S. Baird, Pedro L. Valero-Guillén, Intisar Q. M. Alaraj, Juma'a R. Al Dulayymi, Alison Jones

Publikováno v: Alhuwaymil, Z S, Al-araj, I Q M, Al Dulayymi, A R, Jones, A, Valero-Guillén, P L, Gates, P J, Baird, M S & Al Dulayymi, J R 2020, ' Mycobacterium alvei (ω-1)-methoxy mycolic acids: absolute stereochemistry and synthesis ', Chemistry and Physics of Lipids . https://doi.org/10.1016/j.chemphyslip.2020.104977

Cells of Mycobacterium alvei are known to contain a unique set of mycolic acids with a (ω-1)-methoxy group; although the various enzymes in the biosynthesis of other types of mycolic acid have been widely studied, the biosynthetic route to this subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f3e780f69fa7d9c1046429a5b8600a
https://pubmed.ncbi.nlm.nih.gov/32961166

Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages

Autor: Johan Grooten, Mark S. Baird, Ilke Vermeulen, Juma'a R. Al-Dulayymi, Jan A. Verschoor, Muriel Smet

Publikováno v: Journal of Lipid Research, Vol 58, Iss 4, Pp 709-718 (2017)

The differentiation of macrophages into lipid-filled foam cells is a hallmark of the lung granuloma that forms in patients with active tuberculosis (TB). Mycolic acids (MAs), the abundant lipid virulence factors in the cell wall of Mycobacterium tube

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8df9939f8bd4dca5f58e7be274e94cd
https://doi.org/10.1194/jlr.m073171

Synthesis of a Di-Mycoloyl Tri-Arabinofuranosyl Glycerol Fragment of the Mycobacterial Cell Wall, Based on Synthetic Mycolic Acids

Autor: Juma'a R. Al Dulayymi, Mark S. Baird, Omar T. Ali, Mohsin O. Mohammed

Publikováno v: Molecules, Vol 24, Iss 19, p 3596 (2019)
Molecules
Volume 24
Issue 19

Fragments of mycobacterial cell walls such as arabinoglycerol mycolate and dimycoloyl diarabinoglycerol, comprising complex mixtures of mycolic acids, have immunostimulatory and antigenic properties. A related di-mycoloyl tri-arabinofuranosyl glycero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e078cde061bc4282fde102842ab10141
https://www.mdpi.com/1420-3049/24/19/3596