Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Julius Pollinger"'
Autor:
Matthias Gabler, Jan Kramer, Jurema Schmidt, Julius Pollinger, Julia Weber, Astrid Kaiser, Frank Löhr, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Daniel Merk
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract The bile acid activated transcription factor farnesoid X receptor (FXR) regulates numerous metabolic processes and is a rising target for the treatment of hepatic and metabolic disorders. FXR agonists have revealed efficacy in treating non-a
Externí odkaz:
https://doaj.org/article/a1fdcd19a33746d6872e6c8a2493fca2
Autor:
Apirat Chaikuad, Julius Pollinger, Michael Rühl, Xiaomin Ni, Whitney Kilu, Jan Heering, Daniel Merk
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8457 (2020)
The retinoid X receptor (RXR) is a ligand-sensing transcription factor acting mainly as a universal heterodimer partner for other nuclear receptors. Despite presenting as a potential therapeutic target for cancer and neurodegeneration, adverse effect
Externí odkaz:
https://doaj.org/article/e7816c2c92434c05969099b97c4cdea7
Autor:
Pascal Heitel, Giuseppe Faudone, Moritz Helmstädter, Jurema Schmidt, Astrid Kaiser, Amelie Tjaden, Martin Schröder, Susanne Müller, Simone Schierle, Julius Pollinger, Daniel Merk
Publikováno v:
Communications Chemistry, Vol 3, Iss 1, Pp 1-16 (2020)
Non-alcoholic steatohepatitis demands multiple modes of action for robust therapeutic efficacy. Here the authors design and optimize a triple modulator of farnesoid X receptor and peroxisome proliferator-activated receptors α and δ that counteracts
Autor:
Iris Bischoff, Julius Pollinger, Silvia Arifi, Jan Heering, Whitney Kilu, Manfred Schubert-Zsilavecz, Robert Fürst, Pascal Heitel, Mario Wurglics, Dieter Steinhilber, Werner Pogoda, Stefan Knapp, Leonie Gellrich, Ewgenij Proschak, Alexander Paulke, Apirat Chaikuad, Tamara Goebel, Astrid S. Kahnt, Daniel Merk
Publikováno v:
Journal of Medicinal Chemistry. 63:6727-6740
Thyroid hormones (THs) operate numerous physiological processes through modulation of the nuclear thyroid hormone receptors and several other proteins. We report direct activation of the nuclear peroxisome proliferator-activated receptor gamma (PPAR
Autor:
Julius Pollinger, Julia Ohrndorf, Leonie Gellrich, Astrid Kaiser, Pascal Heitel, Stefan Knapp, Simone Schierle, Daniel Merk, Apirat Chaikuad
Publikováno v:
ACS Med Chem Lett
[Image: see text] The nuclear retinoid X receptors (RXRs) are key ligand sensing transcription factors that serve as universal nuclear receptor heterodimer partners and are thus involved in numerous physiological processes. Therapeutic targeting of R
Autor:
Daniel Merk, Sebastian Neumann, Simone Schierle, Astrid Kaiser, Julius Pollinger, Julia Ohrndorf
Publikováno v:
ChemMedChem. 14:1343-1348
Automated computational analogue design and scoring can speed up hit-to-lead optimization and appears particularly promising in selective optimization of side-activities (SOSA) where possible analogue diversity is confined. Probing this concept, we e
Autor:
Kerstin Hiesinger, Whitney Kilu, Steffen Brunst, Jan S. Kramer, Dieter Steinhilber, Sven George, Julius Pollinger, Jan Heering, Ewgenij Proschak, Daniel Merk
Publikováno v:
Chemmedchem
Designed multitarget ligands are a popular approach to generating efficient and safe drugs, and fragment‐based strategies have been postulated as a versatile avenue to discover multitarget ligand leads. To systematically probe the potential of frag
Autor:
Sabine Willems, Astrid Kaiser, Simone Schierle, Sebastian Neumann, Julius Pollinger, Daniel Merk, Pascal Heitel
Publikováno v:
Journal of medicinal chemistry. 63(15)
Nonalcoholic steatohepatitis (NASH) is considered as severe hepatic manifestation of the metabolic syndrome and has alarming global prevalence. The ligand-activated transcription factors farnesoid X receptor (FXR) and peroxisome proliferator-activate
Autor:
Daniel Merk, Julius Pollinger
Publikováno v:
Expert Opinion on Therapeutic Patents. 27:517-525
WY14643 - also known as pirinixic acid - is a versatile fatty acid mimetic that was originally developed as lipid lowering agent without knowledge of its molecular target. Various later studies discovered somewhat promiscuous activity of the compound
Autor:
Julia Ohrndorf, Jurema Schmidt, Leonie Gellrich, Ewgenij Proschak, Daniel Merk, Simone Schierle, Jan Heering, Lena Kalinowsky, Whitney Kilu, Julius Pollinger, Astrid Kaiser
Publikováno v:
Journal of medicinal chemistry. 62(4)
The fatty acid sensing nuclear receptor families retinoid X receptors (RXRs) and peroxisome proliferator-activated receptors (PPARs) hold therapeutic potential in neurodegeneration. Valuable pleiotropic activities of Wy14,643 in models of such condit