Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Julius Matasi"'
Autor:
Zheng Tan, Steve Sorota, Deen Tulshian, R. Jason Herr, William G. Earley, Charles R. Heap, Stephanie Brumfield, Terry Bridal, Jennifer Hanisak, Xiaoping Zhou, Julius Matasi, Ana Bercovici, Ginny D. Ho, Diane Rindgen, Brandy Courneya, Shu-Wei Yang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4110-4113
A series of pyrrolo-benzo-1,4-diazine analogs have been synthesized and displayed potent Nav1.7 inhibitory activity and moderate selectivity over Nav1.5. The syntheses, structure-activity relationships, and selected pharmacokinetic data of these anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01754d087a669b8aba1f63615bf091ab
https://doi.org/10.1016/j.bmcl.2014.07.060
https://doi.org/10.1016/j.bmcl.2014.07.060
Autor:
Jim Tata, Deen Tulshian, Kristine Devito, William T. McElroy, Daniel Lundell, Thierry O. Fischmann, Charles G. Garlisi, Xiaoda Niu, Bradley Sherborne, James Fossetta, W.M Seganish, Julius Matasi, Brian J. Lavey, Christopher Sondey
We report the identification and synthesis of a series of aminopyrimidin-4-one IRAK4 inhibitors. Through high throughput screening, an aminopyrimidine hit was identified and modified via structure enabled design to generate a new, potent, and kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221275da01563fbe614c45372134905e
https://europepmc.org/articles/PMC4538434/
https://europepmc.org/articles/PMC4538434/
Autor:
Peter Korakas, Duane A. Burnett, Rosalia Bertorelli, Gianluca Lozza, Stephanie Brumfield, T.K. Sasikumar, Cheng Li, Angelo Reggiani, Chad Bennett, Martin S. Domalski, Lisa S. Silverman, Wen-Lian Wu, Li Qiang, Julius Matasi, Chad E. Knutson, Deen Tulshian, Mariagrazia Grilli, William J. Greenlee
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(23)
High throughput screening identified the pyridothienopyrimidinone 1 as a ligand for the metabotropic glutamate receptor 1 (mGluR1=10 nM). Compound 1 has an excellent in vivo profile; however, it displays unfavorable pharmacokinetic issues and metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b067b63e4caa75f87ad61d50f4143220
https://pubmed.ncbi.nlm.nih.gov/23084894
https://pubmed.ncbi.nlm.nih.gov/23084894
Autor:
Jennifer Smotryski, Ginny D. Ho, Shu-Wei Yang, Massimiliano Beltramo, Deen Tulshian, Julius Matasi, Kathleen Cox, Rossella Brusa, William J. Greenlee
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2011, 21 (1), pp.182-185. ⟨10.1016/j.bmcl.2010.11.044⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2011, 21 (1), pp.182-185. ⟨10.1016/j.bmcl.2010.11.044⟩
A series of 2,4-diphenyl-1H-imidazole analogs have been synthesized and displayed potent human CB2 agonist activity. Many of these analogs showed high functional selectivity over human CB1 receptors. The syntheses, structure-activity relationships, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848861f238f4ffedb51ce48579e0ccce
https://pubmed.ncbi.nlm.nih.gov/21115245
https://pubmed.ncbi.nlm.nih.gov/21115245