Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress

Autor: Naama Volk, Julius C. Pape, Mareen Engel, Anthony S. Zannas, Nadia Cattane, Annamaria Cattaneo, Elisabeth B. Binder, Alon Chen

Publikováno v: Cell Reports, Vol 17, Iss 7, Pp 1882-1891 (2016)

MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. Here, we report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex and a

Externí odkaz: https://doaj.org/article/7b5336b76ffa4b99a813fcd00b298797

Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk

Autor: Jens Baumert, Sonja Kunze, Meiwen Jia, Anthony S. Zannas, Elisabeth B. Binder, Bertram Müller-Myhsok, Maria Roitman, Theo Rein, Rebecca T. Emeny, Kerry J. Ressler, Tobias Wiechmann, Melanie Waldenberger, Susanne Lucae, Katri Räikkönen, Andreas Haehle, Felix Hausch, Julius C. Pape, Maik Ködel, Bekh Bradley, Jari Lahti, Janine Arloth, Simone Röh, Kathrin Hafner, Stella Iurato, Johan G. Eriksson, Christian Gieger, Karl-Heinz Ladwig, Alicia K. Smith, Silvia Martinelli, Simone Wahl, Amanda J. Drake, Tania Carrillo-Roa, Nils C. Gassen

Publikováno v: Proc. Natl. Acad. Sci. U.S.A. 166, 11370-11379 (2019)
Proceedings of the National Academy of Sciences of the United States of America
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Zannas, A S, Jia, M, Hafner, K, Baumert, J, Wiechmann, T, Pape, J C, Arloth, J, Ködel, M, Martinelli, S, Roitman, M, Röh, S, Haehle, A, Emeny, R T, Iurato, S, Carrillo-roa, T, Lahti, J, Räikkönen, K, Eriksson, J G, Drake, A J, Waldenberger, M, Wahl, S, Kunze, S, Lucae, S, Bradley, B, Gieger, C, Hausch, F, Smith, A K, Ressler, K J, Müller-myhsok, B, Ladwig, K, Rein, T, Gassen, N C & Binder, E B 2019, ' Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk ', Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.1816847116

Significance Diseases of the aging are the leading cause of morbidity and mortality. Elucidating the molecular mechanisms through which modifiable factors, such as psychosocial stress, confer risk for aging-related disease can have profound implicati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa4c9574c1604bcbedcb31030ddb80f
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=56105

Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress

Autor: Alon Chen, Elisabeth B. Binder, Nadia Cattane, Annamaria Cattaneo, Mareen Engel, Anthony S. Zannas, Naama Volk, Julius C. Pape

Publikováno v: Cell reports
Cell Reports
Cell Reports, Vol 17, Iss 7, Pp 1882-1891 (2016)
Volk, N, Pape, JC, Engel, M, Zannas, AS, Cattane, N, Cattaneo, A, Binder, EB & Chen, A 2016, ' Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress ', Cell Reports, vol. 17, no. 7, pp. 1882-1891 . https://doi.org/10.1016/j.celrep.2016.10.038

Summary MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. Here, we report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a086c40142ddd1c3b5508fa13cdaea74

Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia

Autor: Andrea Schmitt, Nelson Rebola, Susanne Burkhardt, Christophe Mulle, Eva Benito, Ivana Delalle, Roberto Carlos Agis-Balboa, Alexander Jatzko, Gaurav Jain, Patricia A. Zunszain, Sanaz Bahari-Javan, Paulo S. Pinheiro, Julius C. Pape, Markus Dettenhofer, Peter Falkai, Michael Gertig, Farahnaz Sananbenesi, Cemil Kerimoglu, Elisabeth B. Binder, Andre Fischer

Publikováno v: Agís-Balboa, R C, Pinhero, P, Rebola, N, Kerimoglu, C, Benito, E, Gertig, M, Bahari-Javan, S, Jain, G, Burkhardt, S, Delalle, I, Jatzko, A, Dettenhofer, M, Zunszain, P A, Schmitt, A, Falkai, P, Pape, J C, Binder, E B, Mulle, C, Fischer, A & Sananbenesi, F 2017, ' Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia ', The EMBO journal, vol. 36, no. 19, pp. 2815-2828 . https://doi.org/10.15252/embj.201796821
The EMBO journal 36(19), 2815-2828 (2017). doi:10.15252/embj.201796821
RUNA. Repositorio da Consellería de Sanidade e Sergas
Servizo Galego de Saúde (SERGAS)
EMBO JOURNAL
The EMBO Journal

Age-associated memory decline is due to variable combinations of genetic and environmental risk factors. How these risk factors interact to drive disease onset is currently unknown. Here we begin to elucidate the mechanisms by which post-traumatic st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c13c908d6e0f860de3484a7771db35
https://kclpure.kcl.ac.uk/ws/files/80023520/Formin_2_links_neuropsychiatric_AGILS_BALBOA_Publishedonline2August2017_GOLD_VoR_CC_BY_.pdf

Methylene Blue (Tetramethylthionine Chloride) Influences the Mobility of Adult Neural Stem Cells : A Potentially Novel Therapeutic Mechanism of a Therapeutic Approach in the Treatment of Alzheimer's Disease

Autor: Robert J. Schloesser, Jens Benninghoff, Dan Rujescu, Norbert Scherbaum, Dirk M. Hermann, Amelie T. van der Ven, Nadine Fischer, Julius C. Pape, Just Genius, Jens Wiltfang, Rainald Mößner

An interest in neurogenesis in the adult human brain as a relevant and targetable process has emerged as a potential treatment option for Alzheimer's disease and other neurodegenerative conditions. The aim of this study was to investigate the effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a097b56b0185f4af9d46bfc56f953b64
https://www.ncbi.nlm.nih.gov/pubmed/28269766