Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Julius C. Fischer"'
Autor:
Hannah Felchle, Julia Gissibl, Laura Lansink Rotgerink, Sophie M. Nefzger, Caroline N. Walther, Vincent R. Timnik, Stephanie E. Combs, Julius C. Fischer
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 46, Iss , Pp 100758- (2024)
Background: Most clinical studies failed to elicit a strong antitumor immune response and subsequent systemic tumor regression after radiation therapy (RT), even in combination with the immune checkpoint inhibitors (ICI) anti-CTLA4 or anti-PD1. Mecha
Externí odkaz:
https://doaj.org/article/0d6fea93efa140c9bb9ec72ce41887ce
Autor:
Kim M. Kraus, Julius C. Fischer, Kai J. Borm, Marco M. E. Vogel, Steffi. U. Pigorsch, Michal Devečka, Stephanie E. Combs
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The results of this survey reveal current clinical practice in the handling of combined radioimmunotherapy with Immune Checkpoint Inhibitors (RT + ICI). We aim to provide a basis to open a discussion for clinical application of RT + ICI by a
Externí odkaz:
https://doaj.org/article/c7dbc82d084d4c41a32fe2d739dbd70d
Autor:
Simon Heidegger, Diana Kreppel, Michael Bscheider, Florian Stritzke, Tatiana Nedelko, Alexander Wintges, Sarah Bek, Julius C. Fischer, Theresa Graalmann, Ulrich Kalinke, Florian Bassermann, Tobias Haas, Hendrik Poeck
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 146-155 (2019)
Background: Antibody-mediated targeting of regulatory T cell receptors such as CTLA-4 enhances antitumor immune responses against several cancer entities including malignant melanoma. Yet, therapeutic success in patients remains variable underscoring
Externí odkaz:
https://doaj.org/article/d674e7d8808542dc831fe18aab53dc03
Autor:
Sophie Dobiasch, Severin Kampfer, Katja Steiger, Daniela Schilling, Julius C. Fischer, Thomas E. Schmid, Wilko Weichert, Jan J. Wilkens, Stephanie E. Combs
Publikováno v:
Cancers, Vol 13, Iss 22, p 5656 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. Innovative treatment concepts may enhance oncological outcome. Clinically relevant tumor models are essential in developing new therapeutic strategies. In the present st
Externí odkaz:
https://doaj.org/article/5a3238eab5a04bdb99915378320bd913
Autor:
Sarah Bek, Florian Stritzke, Alexander Wintges, Tatiana Nedelko, Daniel F.R. Böhmer, Julius C. Fischer, Tobias Haas, Hendrik Poeck, Simon Heidegger
Publikováno v:
OncoImmunology, Vol 8, Iss 4 (2019)
Resistance to cell death and evasion of immunosurveillance are major causes of cancer persistence and progression. Tumor cell-intrinsic activation of the RNA receptor retinoic acid-inducible gene-I (RIG-I) can trigger an immunogenic form of programme
Externí odkaz:
https://doaj.org/article/8424018ce3be4580b981127040215281
Autor:
Laura Lansink Rotgerink, Hannah Felchle, Annette Feuchtinger, Sophie M Nefzger, Caroline N Walther, Julia Gissibl, Katja Steiger, Thomas E Schmid, Simon Heidegger, Stephanie E Combs, Julius C Fischer
Publikováno v:
The Journal of Pathology. 258:189-198
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy. However, structured knowledge to mitigate a patient's specific risk of developing adverse events are limited. Nevertheless, there is an exponential growth of clinical studies com
Autor:
Stephanie E. Combs, Jan J. Wilkens, Thomas Schmid, Wilko Weichert, Daniela Schilling, Sophie Dobiasch, Julius C. Fischer, Katja Steiger, Severin Kampfer
Publikováno v:
Cancers, Vol 13, Iss 5656, p 5656 (2021)
Cancers; Volume 13; Issue 22; Pages: 5656
Cancers 13:5656 (2021)
Cancers
Cancers; Volume 13; Issue 22; Pages: 5656
Cancers 13:5656 (2021)
Cancers
Simple Summary Despite intense research, the prognosis of patients with pancreatic cancer remains very poor without significant improvements over the past years. Novel therapeutic approaches may contribute to overcome therapeutic resistance and impro
Autor:
Wilko Weichert, S. Baer, Christine Baumgartner, A. Meyer-Lindenberg, Tanja Groll, Martin Grashei, S. Kahl, Julius C. Fischer, Katja Steiger, Franz Schilling, J. Hirschberger
Publikováno v:
Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere.
Autor:
Dirk Büsch, Caroline Walther, Julius C. Fischer, Thomas Engleitner, Stefanie E. Combs, Roland Rad, Simon Heidegger, Marianne Reiser, Laura Lansink Rotgerink, Hendrik Poeck, Gabriel Eisenkolb, Sascha Göttert, Sebastian Jarosch, Lena Klostermeier, Sophie Nefzger, Erik Thiele Orberg, Katja Steiger, Ernst Holler, Florian Bassermann
Publikováno v:
Blood. 138:89-89
Background: Graft-versus-host disease (GVHD) is a dreaded complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Such inflammatory diseases are fostered by damage to the intestinal barrier after transplantation. Consequent
Autor:
Simon Heidegger, Julius C. Fischer, Christian Peschel, Maike Kober, Xian Chang Li, Marc Schmidt-Supprian, Vera Otten, Hendrik Poeck, Marc Rosenbaum, Christoph Drees, Tobias Haas, Silvia Spoerl, Martina Schmickl, Geert van Loo, Rudi Beyaert
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950)
Maintaining immune tolerance requires the production of Foxp3-expressing regulatory T (Treg) cells in the thymus. Activation of NF-κB transcription factors is critically required for Treg cell development, partly via initiating Foxp3 expression. NF-